NESTOR: Retinal Microvascularization and Cardiovascular Disease
Study Details
Study Description
Brief Summary
The main objective of this study is to investigate whether there are links between the blood vessels of the retina as a whole and heart and/or vascular diseases (cardiovascular diseases).
The arteries and veins of the retina are, like the large vessels of the human body (aorta, coronary, cerebral arteries), exposed to the complications of hypertension, diabetes, obesity, dyslipidemia (abnormal blood lipid profile) or tobacco. Several studies have shown that changes in retinal vessels (microvascularization) generally occur several years before damage to large peripheral vessels (macrovascularization). The study of the vessels of the retina is now possible thanks to simple and non-invasive examinations of photographs (not creating any lesion). They allow a painless evaluation of the vessels in the retina.
Ultimately, if this study is conclusive, the patient's cardiovascular risk could be evaluated simply by analysis of the vessels of the retina.
The study is being conducted in the ophthalmology and cardiology departments of Dijon University Hospital. In total, the investigators wish to include approximately 510 patients who present cardiovascular risk factors (255 low risk patients recruited in the ophthalmology department and 255 high risk patients hospitalized in the cardiology department).
All patients participating in the study will be asked to visit the ophthalmology department for a complete examination of the retina.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| High cardiovascular risk patients Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary) |
Other: Optical Coherence Tomography angiography
At the inclusion visit for all patients and at M3 only for 50 patients.
Other: Fundus
At the inclusion visit for all patients and at M3 only for 50 patients.
Other: cardiac ultrasound scan
Only for 50 patients, 3 months after the initial cardiovascular event
|
| Low cardiovascular risk patients Adult patients recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery. The age balance of the patients included in the two groups will be checked regularly. |
Other: Optical Coherence Tomography angiography
At the inclusion visit for all patients and at M3 only for 50 patients.
Other: Fundus
At the inclusion visit for all patients and at M3 only for 50 patients.
|
Outcome Measures
Primary Outcome Measures
- Surface of the avascular zone in the central retina [Baseline]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Person who gave oral consent
-
High cardiovascular risk group: Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary)
-
Low cardiovascular risk group: Adult patients over 40 years of age recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery, ocular surface pathologies and optical correction.
Exclusion Criteria:
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Person not affiliated to national health insurance
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Patient refusal
-
Minor patient
-
Protected patient
-
Ophthalmological history (macular vascular or degenerative disorders)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Chu Dijon Bourogne | Dijon | France | 21000 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire Dijon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MEILLON AOI 2017