Clincosm LogoSign in Get a demo

Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma

Sponsor
Yonsei University (Other)
Overall Status
Unknown status
CT.gov ID
NCT00772993
Collaborator
(none)
400
Enrollment
1
Location
2
Duration (Months)
199.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma. However, varying disc size, myopia and tilted discs affect the thickness of the retinal nerve fiber layer. This study aims to ascertain the ration of the retinal nerve fiber layer against full retina as a predictor of glaucoma diagnosis and progression.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    400 participants
    Time Perspective:
    Prospective
    Official Title:
    Efficacy of RNFL / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma
    Study Start Date :
    Oct 1, 2008
    Anticipated Primary Completion Date :
    Dec 1, 2008
    Anticipated Study Completion Date :
    Dec 1, 2008

    Arms and Interventions

    Arm Intervention/Treatment
    1

    Primary open angle glaucoma
    2

    Normal Control
    3

    Myopia with no evidence of glaucoma
    4

    Myopia with evidence og glaucoma

    Outcome Measures

    Primary Outcome Measures

    1. Ratio of RNFL / Full thickness retina [2 months]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    10 Years to 90 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Primary open angle glaucoma

    • Myopia

    • Myopia with evidence of glaucoma

    • Normal controls

    Exclusion Criteria:

    • Evidence of retinal disease

    • BCVA < 0.4

    • Secondary glaucoma due to intraocular inflammation

    • Lens induced glaucoma

    • Tumor induced glaucoma

    • Neovascular glaucoma

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University School of Medicine Seoul Korea, Republic of 120-752

    Sponsors and Collaborators

    • Yonsei University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00772993
    Other Study ID Numbers:
    • 4-2008-0340
    First Posted:
    Oct 16, 2008
    Last Update Posted:
    Oct 16, 2008
    Last Verified:
    Oct 1, 2008
    Keywords provided by , ,
    glaucoma
    myopia
    myopia with glaucoma
    normal control
    Additional relevant MeSH terms:
    Glaucoma
    Myopia

    Study Results

    No Results Posted as of Oct 16, 2008