Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Study Details
Study Description
Brief Summary
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness. A reduction of the RNFL thickness has been detected in several neurodegenerative diseases, such as multiple sclerosis, CADASIL and Alzheimer's disease. Different studies have reported RNFL changes also in migraine, is a common hereditary chronic neurovascular disorder, characterized by dysfunction of the autonomic nervous system. The pathophysiology of migraine has not been fully clarified, but there is increasing evidence that episodes of migraine with aura are initiated by a focal reduction in cerebral blood flow, which occurs most commonly in the posterior region of one hemisphere. Although vasoconstriction of cerebral and retinal blood vessels is a transient phenomenon, the chronic nature of the migraine might cause permanent structural abnormalities of the brain and also of the retina, which may correlate with RNFL thinning. Previous studies on this subject, however, reported contradicting results. Some investigations reported reductions of the RNFL thickness while others did not. In the present study, in order to determine whether RNFL thickness is reduced in migraine patients, the investigators performed a meta-analysis and systematically evaluated RNFL thickness measurements with OCT in a series of migraine patients and in the healthy control groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| migraine group Patients with migraine |
Device: Device: Optical coherence tomography
|
| healthy control Sex- and agematched healthy subjects |
Device: Device: Optical coherence tomography
|
Outcome Measures
Primary Outcome Measures
- Retinal Nerve Fiber Layer Thickness [Baseline]
Retinal nerve fiber layer thickness included average thickness (360° measurement), temporal quadrant thickness (316-45°), superior quadrant thickness (46-135°), nasal quadrant thickness (136-225°) and inferior quadrant thickness (226-315°)was measured by OCT.
Eligibility Criteria
Criteria
Inclusion Criteria:
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case-control studies;
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patients with Migraine were compared with healthy controls;
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all subjects underwent RNFL thickness measurement by OCT;
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studies should provide the data of peripapillary RNFL thickness;
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sample size ≥10 in each group.
Exclusion Criteria:
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authors did not make RNFL measurements;
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study without healthy control group;
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the outcome values can not be used for meta-analysis;
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duplicated articles.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Zhongshan hospital, Fudan University | Shanghai | Shanghai | China | 200032 |
Sponsors and Collaborators
- Yifan Feng
- Fudan University
Investigators
- Principal Investigator: Yifan Feng, PhD, Fudan University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- FYF20140717