RANCH-COVID: Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Osijek University Hospital (Other)
Overall Status
CT.gov ID

Study Details

Study Description

Brief Summary

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: Chest X-ray

Detailed Description

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Study Design

Study Type:
Anticipated Enrollment :
1000 participants
Observational Model:
Time Perspective:
Official Title:
Radiographic Severity Scoring System and Clinical and Laboratory Evolution of COVID-19 Pneumonia
Actual Study Start Date :
Jan 1, 2020
Anticipated Primary Completion Date :
Dec 1, 2022
Anticipated Study Completion Date :
Dec 1, 2022

Arms and Interventions

Arm Intervention/Treatment
COVID-19 pneumonia patients

Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2

Diagnostic Test: Chest X-ray
Retrospective analysis of chest x-rays of patients with COVID-19

Outcome Measures

Primary Outcome Measures

  1. Chest x-ray severity score [21 days]

    The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined

  2. Inflammatory markers [21 days]

    The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined

Eligibility Criteria


Ages Eligible for Study:
18 Years to 90 Years
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Inclusion Criteria:
  • Pneumonia caused by SARS-CoV-2 virus

  • Admission to the ICU COVID-19 unit

Exclusion Criteria:
  • Patients with lung tumors or history of lung resection

Contacts and Locations


Site City State Country Postal Code
1 University hospital Osijek Osijek Croatia 31000

Sponsors and Collaborators

  • Osijek University Hospital


  • Principal Investigator: Nenad Nešković, PhD, University Hospital Osijek

Study Documents (Full-Text)

None provided.

More Information


Responsible Party:
Osijek University Hospital
ClinicalTrials.gov Identifier:
Other Study ID Numbers:
  • OsijekUH-RC
First Posted:
Jan 6, 2022
Last Update Posted:
May 2, 2022
Last Verified:
Dec 1, 2021
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Keywords provided by Osijek University Hospital
Additional relevant MeSH terms:

Study Results

No Results Posted as of May 2, 2022