RANCH-COVID: Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Sponsor

Osijek University Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT05181696

Collaborator

(none)

1,000

Enrollment

Location

Anticipated Duration (Months)

28.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

Condition or Disease	Intervention/Treatment	Phase
COVID-19 Pneumonia Sepsis SARS-CoV-2 Acute Respiratory Disease Pneumonia Multiorgan Failure	Diagnostic Test: Chest X-ray

Detailed Description

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Study Design

Study Type:

Observational

Anticipated Enrollment :

1000 participants

Observational Model:

Other

Time Perspective:

Retrospective

Official Title:

Radiographic Severity Scoring System and Clinical and Laboratory Evolution of COVID-19 Pneumonia

Actual Study Start Date :

Jan 1, 2020

Anticipated Primary Completion Date :

Dec 1, 2022

Anticipated Study Completion Date :

Dec 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
COVID-19 pneumonia patients Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2	Diagnostic Test: Chest X-ray Retrospective analysis of chest x-rays of patients with COVID-19

Arm

Intervention/Treatment

COVID-19 pneumonia patients

Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2

Diagnostic Test: Chest X-ray

Retrospective analysis of chest x-rays of patients with COVID-19

Outcome Measures

Primary Outcome Measures

Chest x-ray severity score [21 days]
The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined
Inflammatory markers [21 days]
The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined