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Retrospective Analysis of Clinical Features in Ventriculoperitoneal Shunt Infectionsin Adults

Sponsor
University of Pittsburgh (Other)
Overall Status
Completed
CT.gov ID
NCT00524108
Collaborator
(none)
350
Enrollment
1
Location
40
Duration (Months)
8.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The objectives of this study are:

  • To describe the incidence of clinical features in adults with internal ventriculoperitoneal (VP) shunt infections,

  • To determine the validity of laboratory parameters in adults with internal ventriculoperitoneal shunt infections and

  • To evaluate the relationship between the timing of shunt re-implantation with the rates of relapse and secondary infection.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Information from medical records of patients seen by the PI will be collected and analyzed to describe the incidence of clinical features in adults with internal ventriculoperitoneal shunt infections, to determine the validity of laboratory parameters in adults with internal ventriculoperitoneal shunt infections and to evaluate the relationship between the timing of shunt re-implantation with the rates of relapse and secondary infection.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    350 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Retrospective Analysis of Clinical Features in Ventriculoperitoneal Shunt Infections and Time to Re-Implantation in Adults
    Study Start Date :
    Aug 1, 2007
    Actual Primary Completion Date :
    Dec 1, 2010
    Actual Study Completion Date :
    Dec 1, 2010

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • Adults (age >= 18 yrs) with VP shunts (ventriculoatrial [VA], and other cerebrospinal fluid [CSF] catheters will not be included).

      • Cases will include patients with a diagnosis of VP shunt infection.

      • Controls will be patients with a clinical suspicion of shunt infections with negative CSF cultures.

      Exclusion Criteria:
      • Patients with meningitis from community acquired organisms (e.g. Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes and Haemophilus Influenzae).

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 University of Pittsburgh Medical Center Pittsburgh Pennsylvania United States 15213

      Sponsors and Collaborators

      • University of Pittsburgh

      Investigators

      • Principal Investigator: Adarsh Bhimraj, MD, University of Pittsburgh Medical Center

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      University of Pittsburgh
      ClinicalTrials.gov Identifier:
      NCT00524108
      Other Study ID Numbers:
      • PRO07080212
      First Posted:
      Sep 3, 2007
      Last Update Posted:
      Aug 16, 2012
      Last Verified:
      Aug 1, 2012
      Keywords provided by University of Pittsburgh
      shunt
      internal ventriculoperitoneal
      Additional relevant MeSH terms:
      Infections

      Study Results

      No Results Posted as of Aug 16, 2012