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A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore

Sponsor
National University Hospital, Singapore (Other)
Overall Status
Completed
CT.gov ID
NCT00718211
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

To review the characteristics and treatment of gastrointestinal tumours at the two tertiary centres in Singapore

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    A retrospective clinical records review of patients diagnosed with gastrointestinal stromal tumour (GIST) in the two tertiary centres in Singapore i.e. Singapore General Hospital and National University Hospital.

    Gastrointestinal tumours are the most common soft-tissue tumours of the gastrointestinal tracts. Remarkable progress has been made during the last several years in the diagnosis and treatment of GIST. Understanding of the molecular pathogenesis of GIST which is linked to deregulated KIT tyrosine-kinase activity has improved diagnosis, such that GIST is now more frequently and specifically identified. More importantly, systemic tyrosine kinase inhibitor, imatinib, has been used successfully in the treatment of GIST patients with advanced or unresectable disease.

    GIST has been reviewed in the Western literature but there is a lack of Asian data. The review will help us to better understand the disease in our population.Furthermore we will also examine several unresolved issues in the Western literature by looking into our local data. These include required duration of imatinib therapy, role of imatinib in the adjuvant setting (application of chemotherapy after macroscopically complete removal of tumour) and role of combination therapies.

    The medical records of all patients diagnosed with the disease at the two centres will be reviewed.

    Analysis of the results aims to:

    1. to compare the characteristics of the GIST (epidemiology, site, morphology, immunohistochemistry profile) in our centres compared to the well-published literature.

    2. to compare the treatment regimen and results of our centres compared to others

    3. to review the role of chemotherapy in the adjuvant settings in the centres.

    Study Design

    Study Type:
    Observational
    Official Title:
    A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in Singapore.
    Study Start Date :
    May 1, 2006
    Actual Primary Completion Date :
    Sep 1, 2013

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • Patients diagnosed with Gastrointestinal stromal tumor.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 National University Hospital Singapore Singapore

      Sponsors and Collaborators

      • National University Hospital, Singapore

      Investigators

      • Principal Investigator: Ross Andrew Soo, MBBS, National University Hospital, Singapore

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      National University Hospital, Singapore
      ClinicalTrials.gov Identifier:
      NCT00718211
      Other Study ID Numbers:
      • GA01/12/06
      First Posted:
      Jul 18, 2008
      Last Update Posted:
      Mar 30, 2020
      Last Verified:
      Jan 1, 2014
      Additional relevant MeSH terms:
      Gastrointestinal Stromal Tumors

      Study Results

      No Results Posted as of Mar 30, 2020