A Retrospective Study on the Relationship Between Donor Leukocyte Telomere Length and Prognosis of Acute Leukemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation
Study Details
Study Description
Brief Summary
This post hoc analysis included patients with acute leukemia who underwent allo-HSCT at the First Affiliated Hospital of Zhejiang University School of Medicine and Ruijin Hospital Shanghai Jiaotong University School of Medicine. Patients and their donors were assessed for eligibility to join this study. The inclusion criteria were: (1) age ≥ 5 years; (2) diagnosis of acute leukemia including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia; (3) patients attained complete remission (CR) and achieved full engraftment with 100% donor chimerism following allo-HSCT; (4) telomere testing was conducted on peripheral leukocytes of donors before granulocyte colony-stimulating factor (G-CSF) mobilization, and the results were obtained. Written informed consent was obtained from all included patients and their donors, and the study was conducted in compliance with the Declaration of Helsinki. Ethical approval was approved by the ethics review committee of the First Affiliated Hospital of Zhejiang University School of Medicine.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Donors aged 40 years or older
|
Other: No intervention, observation study
No intervention, observation study
|
| Donors aged < 40
|
Other: No intervention, observation study
No intervention, observation study
|
Outcome Measures
Primary Outcome Measures
- Overall survival [From date of transplantuntil the date of death from any cause, assessed up to 60 months.]
The duration from transplant until death resulted from any cause.
Secondary Outcome Measures
- Relapse-free survival [From date of transplant until the date of relapse or death from any cause, assessed up to 60 months.]
The time from transplant until death or relapse.
- Cumulative incidence of relapse [From date of transplant until the date of relapse, assessed up to 60 months.]
The time interval between the transplant and the occurrence of relapse.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age ≥ 5 years
-
First allo-HSCT from matched related, unrelated, or haploidentical donors
-
Achievement of complete remission after allo-HSCT
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Donor blood sample collection before granulocyte colony-stimulating factor mobilization
Exclusion Criteria
-
Non-acute leukemia diagnoses, including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia
-
Failure to achieve engraftment with full donor chimerism after allo-HSCT
-
Inability to extract DNA for telomere length analysis.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Clinical research ethics committee of the first affiliated hospital, college of medicine, zhejiang University | Hangzhou | Zhejiang | China |
Sponsors and Collaborators
- Zhejiang University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Telo-2015-HSCT