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Retrospective Review of CT and MR in Pediatric Patients With Cholestasis

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT01252043
Collaborator
(none)
80
Enrollment
1
Location
12
Duration (Months)
6.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators will try to predict the risk of esophageal varices (EVs) in long-term BA survivors using noninvasive computed tomography (CT) or magnetic resonance (MR) indices and the measurement of transverse diameters of paraesophageal and gastroesophageal veins.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    We intend to review retrospectively 80 pediatric patients on an average of 2 years, who underwent 64-slice CT or MR examinations between January 2005 and Oct 2010 and had EVs on esophagogastroduodenoscopy. Splenic diameters (mm) and hepatic diameters of all patients were measured. Splenic and hepatic volume indices also calculated. The transverse diameters of paraesophageal varices (PVs) and perigastric varices (PGVs) were measured adjacent to the lower thoracic esophagus and within the lesser sac, respectively.

    We will try to find out the possible splenic, hepatic or vascular predicting factors useful to evaluate the risk of clinically evident esophageal varices.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    80 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Retrospective Review of Computed Tomography and Magnetic Resonance Images in Pediatric Patients With Cholestasis
    Study Start Date :
    Oct 1, 2010
    Anticipated Primary Completion Date :
    Oct 1, 2011
    Anticipated Study Completion Date :
    Oct 1, 2011

    Arms and Interventions

    Arm Intervention/Treatment
    cohort

    cholestatic children without esophageal variceal bleeding
    study

    cholestatic children with esophageal variceal bleeding
    cholestatic children without EV

    cholestatic children without esophageal variceal bleeding

    Outcome Measures

    Primary Outcome Measures

    1. esophageal variceal bleeding [retrospective review]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A to 18 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • all cholestatic children with CT, MR and complete medical record
    Exclusion Criteria:
    • all cholestatic children without either CT, MR or complete medical record

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Taiwan University Hospital Taipei Taiwan 100

    Sponsors and Collaborators

    • National Taiwan University Hospital

    Investigators

    • Study Chair: Tiffany TF Shih, M.D., Department of Medical Imaging, National Taiwan University Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT01252043
    Other Study ID Numbers:
    • 201010044R
    First Posted:
    Dec 2, 2010
    Last Update Posted:
    Dec 2, 2010
    Last Verified:
    Nov 1, 2010
    Keywords provided by , ,
    cholestasis
    children
    Additional relevant MeSH terms:
    Cholestasis

    Study Results

    No Results Posted as of Dec 2, 2010