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Retrospective Analysis of Surgical Outcomes After Corneal Transplantation

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01547975
Collaborator
(none)
1,000
Enrollment
1
Location
23
Duration (Months)
43.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. National Taiwan University Hospital (NTUH), as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    An insufficient donor supply is a worldwide problem in organ transplantation. Even with corneal transplantations, the most widely performed transplantation, shortages and imbalances in donor supply is a global concern. In National Taiwan University Hospital (NTUH), the investigators performed over one hundred of corneal transplantations every year and the majority of donor corneas were from the eye bank in United States. Previous literature showed satisfactory results in corneal transplantation using foreign donor corneas compared with domestic corneas. However longer preservation time had associated with a statistically significant increased risk of persistence of the postoperative epithelial defect. On the other hand, longer storage times may allow better outcomes in high-risk grafts because of the depletion of donor T cells from the donor cornea into the storage media.

    Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. NTUH, as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    1000 participants
    Observational Model:
    Case-Crossover
    Time Perspective:
    Retrospective
    Official Title:
    Retrospective Analysis of Surgical Outcomes After Corneal Transplantation
    Study Start Date :
    Apr 1, 2010
    Actual Primary Completion Date :
    Mar 1, 2012
    Actual Study Completion Date :
    Mar 1, 2012

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A to 90 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • The patients who received corneal transplantation within full chart records
      Exclusion Criteria:

      • The patients have cognitive Impairment.

      • No detail or unclear ophthalmologic record.

      • Patients or their legal representative have no willing to accept this tracing study.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 National Taiwan University Hospital, department of Ophthalmology Taipei Taiwan 100

      Sponsors and Collaborators

      • National Taiwan University Hospital

      Investigators

      • Study Chair: Wei-Li Chen, MD,PhD, NTUH

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      National Taiwan University Hospital, Wei-Li Chen, MD, PhD, Assistant Professor, National Taiwan University Hospital, department of Ophthalmology., National Taiwan University Hospital
      ClinicalTrials.gov Identifier:
      NCT01547975
      Other Study ID Numbers:
      • 201004004R
      First Posted:
      Mar 8, 2012
      Last Update Posted:
      Apr 3, 2012
      Last Verified:
      Mar 1, 2012
      Keywords provided by National Taiwan University Hospital, Wei-Li Chen, MD, PhD, Assistant Professor, National Taiwan University Hospital, department of Ophthalmology., National Taiwan University Hospital
      surgical outcomes after corneal transplantation
      Retrospective analysis
      corneal transplantation

      Study Results

      No Results Posted as of Apr 3, 2012