Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus

Sponsor

Dr. Ersin Arslan Education and Training Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT04363125

Collaborator

Inonu University (Other)

310

Enrollment

Location

15.6

Actual Duration (Months)

19.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Condition or Disease	Intervention/Treatment	Phase
Pathology Sigmoid Volvulus Hypoganglionosis	Diagnostic Test: Pathology result

Detailed Description

Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis. Pubmed and Scopus databases were scanned. No restrictions were used in the written language. Only isolated cases of hypoganglionosis were added to the study. In the cases; author, year of publication, country of publication, age, gender, surgical or non-surgical treatments, treatment results, and mortalities were examined.

When sigmoid volvulus is seen in children and adolescents, congenital neurological bowel diseases should be considered in the differential diagnosis. Hirschprung's disease must be ruled out by rectal biopsy. The histopathological investigation should be carried out for the diagnosis and determination of surgical margins in isolated hypoganglionosis.

Study Design

Study Type:

Observational

Actual Enrollment :

310 participants

Observational Model:

Case-Only

Time Perspective:

Other

Official Title:

Systematic Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus

Actual Study Start Date :

Jan 1, 2019

Actual Primary Completion Date :

Apr 1, 2020

Actual Study Completion Date :

Apr 20, 2020

Outcome Measures

Primary Outcome Measures

Mortality [three months]
Mortality of sigmoid volvulus due to isolated hypoganglionosis

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

isolated hypoganglionosis
our case of isolated hypoganglionosis

Exclusion Criteria:

hypoganglionosis with Hirschsprung's disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Dr. Ersin Arslan Training and Resource Hospital	Gaziantep		Turkey

Sponsors and Collaborators

Dr. Ersin Arslan Education and Training Hospital
Inonu University

Investigators

Principal Investigator: ufuk uylas, Specialist, Dr. Ersin Arslan Training and Resource Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Ufuk Uylas, Principal Investigator, Dr. Ersin Arslan Education and Training Hospital

ClinicalTrials.gov Identifier:

NCT04363125

Other Study ID Numbers:

23042020

First Posted:

Apr 27, 2020

Last Update Posted:

Apr 28, 2020

Last Verified:

Apr 1, 2020

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Ufuk Uylas, Principal Investigator, Dr. Ersin Arslan Education and Training Hospital

intestinal neuronal dysplasia

Additional relevant MeSH terms:

Intestinal Volvulus

Study Results

No Results Posted as of Apr 28, 2020