Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)
Study Details
Study Description
Brief Summary
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed.
ABBV-154 is an investigational drug being evaluated for the treatment of RA. Study doctors place the participants in 1 of 5 treatment groups or arms, each arm receiving a different treatment. There is a 1 in 5 chance that participants will be assigned to placebo. Participants 18-75 years of age with moderate to severe RA will be enrolled. Around 425 participants will be enrolled in the study in approximately 270 sites worldwide.
The study is compromised of a 12 week placebo-controlled period, a double-blind long term extension (LTE) period 1 of 66 weeks, a LTE period 2 of 104 weeks and a follow-up visit 70 days after the last dose of the study drug. In the LTE period 1, participants in the placebo group will be re-randomized to receive ABBV-154 in 2 different doses SC every other week (eow). Other participants will remain on their previous dose and dosing regimen of ABBV-154.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Dose A of ABBV-154 Participants in this group will receive dose A of ABBV-154 subcutaneously (SC) every other week (eow) for 12 weeks in the placebo-controlled period, 66 weeks in the long term extension (LTE) period 1 and 104 weeks in LTE period 2. |
Drug: ABBV-154
Subcutaneous Injection
|
| Experimental: Dose B of ABBV-154 Participants in this group will receive dose B of ABBV-154 SC eow for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. |
Drug: ABBV-154
Subcutaneous Injection
|
| Experimental: Dose C of ABBV-154 EOW Participants in this group will receive dose C of ABBV-154 SC eow for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. |
Drug: ABBV-154
Subcutaneous Injection
|
| Experimental: Dose C of ABBV-154 E4W Participants in this group will receive dose C of ABBV-154 SC every 4 weeks (e4w) for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. |
Drug: ABBV-154
Subcutaneous Injection
|
| Experimental: Placebo Participants in this group will receive placebo SC eow for 12 weeks in the placebo-controlled period and will be re-randomized in 1:1 ratio to receive ABBV-154 dose B or C respectively SC eow for 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. |
Drug: ABBV-154
Subcutaneous Injection
Drug: Placebo
Subcutaneous Injection
|
Outcome Measures
Primary Outcome Measures
- Percentage of Participants Achieving American College of Rheumatology 50 % (ACR50) Response [At 12 weeks]
Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR50 response criteria: ≥ 50% improvement in 68-tender joint count; ≥ 50% improvement in 66-swollen joint count; and ≥ 50% improvement in at least 3 of the 5 following parameters: Physician's Global Assessment of Disease Activity measured on a Numerical Rating Scale of 0 to 10 (NRS) Patient's Global Assessment of Disease Activity (NRS) Patient's Assessment of Pain (NRS) Health Assessment Questionnaire - Disability Index (HAQ-DI) High-sensitivity C-reactive protein (hsCRP).
Secondary Outcome Measures
- Change in Disease Activity Score (DAS) 28 (CRP) from Baseline [Up to 12 weeks]
The DAS28 is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and hsCRP (in mg/L). Scores on the DAS28 range from 0 to approximately 10, where higher scores indicate more disease activity.
- Change in Clinical Disease Activity Index (CDAI) from Baseline [Up to 12 weeks]
CDAI is a composite index for assessing disease activity based on the sum of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and Physician's Global Assessment of Disease Activity (NRS). The total CDAI score ranges from 0 to 76 with higher scores indicating higher disease activity.
- Percentage of Participants Achieving American College of Rheumatology 20 % (ACR20) Response [At 12 weeks]
Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR20 response criteria: ≥ 20% improvement in 68-tender joint count; ≥ 20% improvement in 66-swollen joint count; and ≥ 20% improvement in at least 3 of the 5 following parameters: Physician's Global Assessment of Disease Activity (NRS) Patient's Global Assessment of Disease Activity (NRS) Patient's Assessment of Pain (NRS) Health Assessment Questionnaire - Disability Index (HAQ-DI) High-sensitivity C-reactive protein (hsCRP).
- Percentage of Participants Achieving American College of Rheumatology 70 % (ACR70) Response [At 12 weeks]
Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR70 response criteria: ≥ 70% improvement in 68-tender joint count; ≥ 70% improvement in 66-swollen joint count; and ≥ 70% improvement in at least 3 of the 5 following parameters: Physician's Global Assessment of Disease Activity (NRS) Patient's Global Assessment of Disease Activity (NRS) Patient's Assessment of Pain (NRS) Health Assessment Questionnaire - Disability Index (HAQ-DI) High-sensitivity C-reactive protein (hsCRP).
- Percentage of Participants Achieving Low Disease Activity (LDA) Defined by DAS28 (CRP) <= 3.2 [At 12 weeks]
Low disease activity (LDA) was defined as a DAS28 score less than or equal to 3.2. The DAS28 is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS) and Physician's Global Assessment of Disease Activity (NRS), and hsCRP (in mg/L). Scores on the DAS28 range from 0 to approximately 10, where higher scores indicate more disease activity.
- Percentage of Participants Achieving LDA Defined by CDAI <= 10 [At 12 weeks]
Low disease activity based on CDAI is defined as a CDAI score less than or equal to 10. CDAI is a composite index for assessing disease activity based on the sum of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and Physician's Global Assessment of Disease Activity (NRS). The total CDAI score ranges from 0 to 76 with higher scores indicating higher disease activity.
- Percentage of Participants Achieving Clinical Remission (CR) Defined by DAS28 (CRP) < 2.6 [At 12 weeks]
Clinical remission was defined as a DAS28 (CRP) score less than 2.6. The DAS28 is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and hsCRP (in mg/L). Scores on the DAS28 range from 0 to approximately 10, where higher scores indicate more disease activity.
- Percentage of Participants Achieving CR Defined by CDAI <= 2.8 [At 12 weeks]
Clinical Remission was defined by CDAI as a score less than or equal to 2.8. CDAI is a composite index for assessing disease activity based on the summation of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and Physician's Global Assessment of Disease Activity (NRS). The total CDAI score ranges from 0 to 76 with higher scores indicating higher disease activity.
- Change in the Health Assessment Questionnaire Disability Index (HAQ-DI) From Baseline [Up to 12 weeks]
The Health Assessment Questionnaire - Disability Index is a participant-reported questionnaire that measures the degree of difficulty a person has in accomplishing tasks in 8 functional areas (dressing, arising, eating, walking, hygiene, reaching, gripping, and errands and chores) over the past week. Participants assessed their ability to do each task on a scale from 0 (without any difficulty) to 3 (unable to do). Scores were averaged to provide an overall score ranging from 0 to 3, where 0 represents no disability and 3 represents very severe, high-dependency disability. A negative change from Baseline in the overall score indicates improvement.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Clinical diagnosis of rheumatoid arthritis(RA) with fulfillment of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for RA.
-
Participant has >= 6 swollen joints (based on 66 joint count) and >=6 tender joints (based on 68 joint count) at baseline.
-
Participant must have had an inadequate response to at least one prior biologic and/or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) treatment for RA.
-
Participants must be on stable dose of methotrexate (MTX).
Exclusion Criteria:
- Participant discontinued prior adalimumab therapy due to intolerability or toxicity.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Elite Clinical Studies, LLC /ID# 228227 | Phoenix | Arizona | United States | 85018 |
| 2 | Arthritis and Rheumatism Associates /ID# 228201 | Jonesboro | Arkansas | United States | 72401-6251 |
| 3 | Providence Medical Foundation /ID# 228104 | Fullerton | California | United States | 92835 |
| 4 | Care Access Research, Huntington Beach /ID# 228163 | Huntington Beach | California | United States | 92648 |
| 5 | San Diego Rheumatology /ID# 228120 | La Mesa | California | United States | 91942 |
| 6 | Arthritis & Osteo Medical Ctr /ID# 228239 | La Palma | California | United States | 90623-1728 |
| 7 | Pacific Arthritis Care Center - Los Angeles /ID# 229330 | Los Angeles | California | United States | 90045-6200 |
| 8 | California Medical Research Associates /ID# 230131 | Northridge | California | United States | 91324 |
| 9 | Arthritis Care And Research Center ACRC /ID# 230099 | Poway | California | United States | 92064 |
| 10 | East Bay Rheumatology Medical /ID# 228099 | San Leandro | California | United States | 94578 |
| 11 | Millennium Clinical Trials /ID# 230618 | Thousand Oaks | California | United States | 91360-3951 |
| 12 | The Lundquist Institute at Harbor-UCLA Medical Center /ID# 228241 | Torrance | California | United States | 90502 |
| 13 | Medvin Clinical Research /ID# 228181 | Tujunga | California | United States | 91042-2706 |
| 14 | Inland Rheum & Osteo Med Grp /ID# 228204 | Upland | California | United States | 91786 |
| 15 | Comprehensive Rheumatology Center /ID# 230132 | West Hills | California | United States | 91307-2003 |
| 16 | Denver Arthritis Clinic /ID# 228172 | Denver | Colorado | United States | 80230 |
| 17 | New England Research Associates, LLC /ID# 230127 | Bridgeport | Connecticut | United States | 06606-1827 |
| 18 | Stamford Therapeutics Consorti /ID# 229214 | Stamford | Connecticut | United States | 06905 |
| 19 | Delaware Arthritis /ID# 229413 | Lewes | Delaware | United States | 19958 |
| 20 | Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 228229 | Boca Raton | Florida | United States | 33486 |
| 21 | Bay Area Arthritis and Osteo /ID# 228075 | Brandon | Florida | United States | 33511 |
| 22 | Clinical Research of West Florida, Inc /ID# 228128 | Clearwater | Florida | United States | 33765 |
| 23 | International Medical Research - Daytona /ID# 228069 | Daytona Beach | Florida | United States | 32117 |
| 24 | Omega Research Debary, LLC /ID# 228293 | DeBary | Florida | United States | 32713-2260 |
| 25 | Sweet Hope Research Specialty Inc /ID# 228753 | Hialeah | Florida | United States | 33016-1897 |
| 26 | University of Florida /ID# 228242 | Jacksonville | Florida | United States | 32209 |
| 27 | Lakes Research, LLC /ID# 228665 | Miami | Florida | United States | 33014 |
| 28 | University of Miami /ID# 228737 | Miami | Florida | United States | 33136 |
| 29 | Suncoast Clinical Research /ID# 228237 | New Port Richey | Florida | United States | 34652 |
| 30 | Omega Research Maitland, LLC /ID# 229966 | Orlando | Florida | United States | 32808 |
| 31 | HMD Research LLC /ID# 228185 | Orlando | Florida | United States | 32819 |
| 32 | Millennium Research /ID# 228183 | Ormond Beach | Florida | United States | 32174 |
| 33 | Arthritis Center, Inc. /ID# 228209 | Palm Harbor | Florida | United States | 34684 |
| 34 | BayCare Medical Group /ID# 228289 | Saint Petersburg | Florida | United States | 33705 |
| 35 | West Broward Rheumatology Associates /ID# 228603 | Tamarac | Florida | United States | 33321 |
| 36 | Clinical Research of West Florida - Tampa /ID# 228186 | Tampa | Florida | United States | 33606-1246 |
| 37 | Conquest Research /ID# 230560 | Winter Park | Florida | United States | 32789 |
| 38 | Florida Medical Clinic /ID# 228236 | Zephyrhills | Florida | United States | 33542 |
| 39 | Arthritis and Rheumatology /ID# 228743 | Atlanta | Georgia | United States | 30342 |
| 40 | Jefrey D. Lieberman, MD, P.C. /ID# 230129 | Decatur | Georgia | United States | 30033 |
| 41 | Arthritis Center of North GA /ID# 228769 | Gainesville | Georgia | United States | 30501 |
| 42 | Atlanta Research Center for Rheumatology /ID# 230430 | Marietta | Georgia | United States | 20060 |
| 43 | Great Lakes Clinical Trials /ID# 228699 | Chicago | Illinois | United States | 60640 |
| 44 | Greater Chicago Specialty Physicians /ID# 228282 | Schaumburg | Illinois | United States | 60195-3106 |
| 45 | Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 228174 | Skokie | Illinois | United States | 60076 |
| 46 | Springfield Clinic /ID# 228124 | Springfield | Illinois | United States | 62702-3749 |
| 47 | Beacon Medical Group Clinical Research /ID# 229153 | Granger | Indiana | United States | 46530 |
| 48 | University of Iowa Hospitals and Clinics /ID# 229217 | Iowa City | Iowa | United States | 52242 |
| 49 | Four Rivers Clinical Research /ID# 230109 | Paducah | Kentucky | United States | 42001 |
| 50 | The Arthritis & Diabetes Clinic, Inc. /ID# 228221 | Monroe | Louisiana | United States | 71203 |
| 51 | Klein and Associates MD /ID# 230145 | Hagerstown | Maryland | United States | 21740 |
| 52 | Klein and Associates MD - Hagerstown /ID# 230143 | Hagerstown | Maryland | United States | 21742 |
| 53 | The Center for Rheumatology and Bone Research /ID# 228617 | Wheaton | Maryland | United States | 20902 |
| 54 | AA Medical Research Center /ID# 228604 | Grand Blanc | Michigan | United States | 48439 |
| 55 | Advanced Rheumatology, PC /ID# 228684 | Lansing | Michigan | United States | 48910 |
| 56 | June DO, PC /ID# 229838 | Lansing | Michigan | United States | 48910 |
| 57 | Arthritis Associates /ID# 230188 | Hattiesburg | Mississippi | United States | 39402 |
| 58 | Rheumatology Consultants - Clinical Research /ID# 229208 | Tupelo | Mississippi | United States | 38801-4949 |
| 59 | Clayton Medical Associates, P.C. dba Saint Louis Rheumatology /ID# 228283 | Saint Louis | Missouri | United States | 63119-3845 |
| 60 | West County Rheumatology /ID# 228102 | Saint Louis | Missouri | United States | 63131-1703 |
| 61 | Logan Health Research /ID# 228273 | Kalispell | Montana | United States | 59901 |
| 62 | Advanced Biomedical Research of America /ID# 228596 | Las Vegas | Nevada | United States | 89123 |
| 63 | Innovative Health Research /ID# 229209 | Las Vegas | Nevada | United States | 89128 |
| 64 | Arthritis and Osteoporosis Associates /ID# 229418 | Freehold | New Jersey | United States | 07728-8307 |
| 65 | Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 228602 | Voorhees | New Jersey | United States | 08043 |
| 66 | Albuquerque Center For Rheumatology /ID# 228709 | Albuquerque | New Mexico | United States | 87102 |
| 67 | Albuquerque Clinical Trials, Inc /ID# 228925 | Albuquerque | New Mexico | United States | 87102 |
| 68 | Arthritis and Osteo Assoc /ID# 228662 | Las Cruces | New Mexico | United States | 88011 |
| 69 | Buffalo Rheumatology and Medicine - Orchard Park /ID# 228710 | Orchard Park | New York | United States | 14127 |
| 70 | St. Lawrence Health System /ID# 229508 | Potsdam | New York | United States | 13676 |
| 71 | DJL Clinical Research, PLLC /ID# 230133 | Charlotte | North Carolina | United States | 28210-8508 |
| 72 | Cape Fear Arthritis Care /ID# 228747 | Leland | North Carolina | United States | 28451 |
| 73 | PMG Research of Salisbury /ID# 230627 | Salisbury | North Carolina | United States | 28144 |
| 74 | Trinity Health Med Arts Clinic /ID# 228202 | Minot | North Dakota | United States | 58701 |
| 75 | University of Cincinnati /ID# 229212 | Cincinnati | Ohio | United States | 45267-0585 |
| 76 | Paramount Medical Research Con /ID# 228254 | Middleburg Heights | Ohio | United States | 44130 |
| 77 | Arthritis Assoc of NW Ohio /ID# 228936 | Toledo | Ohio | United States | 43606 |
| 78 | Arthritis and Rheumatology Center of Oklahoma /ID# 228975 | Oklahoma City | Oklahoma | United States | 73102 |
| 79 | Rheumatology Associates of Oklahoma /ID# 228701 | Oklahoma City | Oklahoma | United States | 73116-7226 |
| 80 | Advanced Rheumatology & Arthritis Wellness Center /ID# 228608 | Cranberry Township | Pennsylvania | United States | 16066 |
| 81 | Altoona Ctr Clinical Res /ID# 230058 | Duncansville | Pennsylvania | United States | 16635 |
| 82 | Arthritis Group /ID# 229777 | Philadelphia | Pennsylvania | United States | 19152 |
| 83 | PA Regional Center for Arthritis and Osteoporosis Research /ID# 228742 | Wyomissing | Pennsylvania | United States | 19610 |
| 84 | Columbia Arthritis Center /ID# 228705 | Columbia | South Carolina | United States | 29204 |
| 85 | West Tennessee Research Institute /ID# 228257 | Jackson | Tennessee | United States | 38305 |
| 86 | Arthritis and Rheumatology Research Institute, PLLC /ID# 228937 | Allen | Texas | United States | 75013-6147 |
| 87 | Allen Arthritis /ID# 228712 | Allen | Texas | United States | 75013 |
| 88 | Trinity Universal Research Associates - Carrollton /ID# 230104 | Carrollton | Texas | United States | 75007 |
| 89 | Adriana Pop-Moody MD Clinic PA /ID# 230062 | Corpus Christi | Texas | United States | 78404 |
| 90 | Rheumatology Clinic of Houston /ID# 228178 | Houston | Texas | United States | 77065 |
| 91 | West Texas Clinical Research /ID# 228276 | Lubbock | Texas | United States | 79410-1198 |
| 92 | P&I Clinical Research /ID# 230183 | Lufkin | Texas | United States | 75904-3132 |
| 93 | SW Rheumatology Res. LLC /ID# 228088 | Mesquite | Texas | United States | 75150 |
| 94 | Trinity Universal Research Associates, Inc /ID# 228238 | Plano | Texas | United States | 75024-5283 |
| 95 | Epic Medical Research /ID# 228097 | Red Oak | Texas | United States | 75154-3981 |
| 96 | Sun Research Institute /ID# 228768 | San Antonio | Texas | United States | 78215 |
| 97 | Advanced Rheumatology of Houston /ID# 228170 | The Woodlands | Texas | United States | 77382 |
| 98 | DM Clinical Research - Tomball /ID# 228112 | Tomball | Texas | United States | 77375 |
| 99 | Arthritis & Osteoporosis Clinic /ID# 228736 | Waco | Texas | United States | 76710 |
| 100 | Tidewater Physicians Medical Center /ID# 230130 | Newport News | Virginia | United States | 23606-4434 |
| 101 | Arthritis Northwest, PLLC /ID# 228275 | Spokane | Washington | United States | 99204-2302 |
| 102 | Emeritus Research Sydney /ID# 230070 | Botany | New South Wales | Australia | 2019 |
| 103 | BJC Health /ID# 229015 | Paramatta | New South Wales | Australia | 2150 |
| 104 | Rheumatology Research Unit Sunshine Coast /ID# 229017 | Maroochydore | Queensland | Australia | 4558 |
| 105 | The Queen Elizabeth Hospital /ID# 230071 | Woodville South | South Australia | Australia | 5011 |
| 106 | Emeritus Research /ID# 229018 | Camberwell | Victoria | Australia | 3124 |
| 107 | Rheumatology Research Associates /ID# 227818 | Edmonton | Alberta | Canada | T5M 0H4 |
| 108 | Manitoba Clinic /ID# 227822 | Winnipeg | Manitoba | Canada | R3A 1M3 |
| 109 | Groupe de Recherche en Maladies Osseuses Inc /ID# 227821 | Sainte-foy | Quebec | Canada | G1V 3M7 |
| 110 | Centre de Recherche Musculo-Squelettique /ID# 227824 | Trois-rivières | Quebec | Canada | G8Z 1Y2 |
| 111 | Dr. Latha Naik /ID# 227823 | Saskatoon | Saskatchewan | Canada | S7K 3H3 |
| 112 | Revmatologicky ustav v Praze /ID# 229188 | Praha | Czechia | 128 00 | |
| 113 | PV MEDICAL Services s.r.o. /ID# 228265 | Praha | Czechia | 130 00 | |
| 114 | Revmatologicka ambulance - MUDr. Zuzana Urbanova /ID# 227775 | Praha | Czechia | 140 00 | |
| 115 | Fakultni Nemocnice v Motole /ID# 231622 | Praha | Czechia | 150 06 | |
| 116 | MEDICAL PLUS, s.r.o. /ID# 228030 | Uherske Hradiste | Czechia | 686 01 | |
| 117 | RHEUMA s.r.o. /ID# 230850 | Velke Bilovice | Czechia | 691 02 | |
| 118 | Rheumazentrum Ruhrgebiet /ID# 227850 | Herne | Nordrhein-Westfalen | Germany | 44649 |
| 119 | Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 229526 | Berlin | Germany | 10117 | |
| 120 | MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 227785 | Hamburg | Germany | 20095 | |
| 121 | General Hospital of Athens Gennimatas /ID# 227806 | Athens | Attiki | Greece | 11527 |
| 122 | University General Hospital of Heraklion PA.G.N.I /ID# 227804 | Heraklion | Kriti | Greece | 71500 |
| 123 | 424 General MILITARY Hospital /ID# 227805 | Efkarpia (Thessalonikis) | Thessaloniki | Greece | 56429 |
| 124 | General Hospital of Thessaloniki Hippokrateio /ID# 229614 | Thessaloniki | Greece | 54642 | |
| 125 | Debreceni Egyetem Klinikai Kozpont /ID# 228371 | Debrecen | Hajdu-Bihar | Hungary | 4032 |
| 126 | Obudai Egeszsegugyi Centrum Kft. /ID# 228359 | Budapest | Pest | Hungary | 1036 |
| 127 | DRC Gyogyszervizsgalo Kozpont Kft /ID# 228365 | Balatonfüred | Hungary | 8230 | |
| 128 | Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 227671 | Budapest | Hungary | 1023 | |
| 129 | Revita Reumatologiai Rendelo /ID# 227668 | Budapest | Hungary | 1027 | |
| 130 | CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 227670 | Szekesfehervar | Hungary | 8000 | |
| 131 | Vital Medical Center Orvosi es Fogaszati Kozpont (Vital Medicina Kft.) /ID# 227669 | Veszprém | Hungary | 8200 | |
| 132 | Obudai Egeszsegugyi Centrum Kft. Zalaegerszeg /ID# 228374 | Zalaegerszeg | Hungary | 8900 | |
| 133 | The Chaim Sheba Medical Center /ID# 226797 | Ramat Gan | Tel-Aviv | Israel | 5265601 |
| 134 | Tel Aviv Sourasky Medical Center /ID# 228341 | Tel Aviv-Yafo | Tel-Aviv | Israel | 6423906 |
| 135 | Rambam Health Care Campus /ID# 226798 | Haifa | Israel | 3109601 | |
| 136 | Bnai Zion Medical Center /ID# 226801 | Haifa | Israel | 3339419 | |
| 137 | The Lady Davis Carmel Medical Center /ID# 226802 | Haifa | Israel | 34362 | |
| 138 | Meir Medical Center /ID# 226800 | Kfar Saba | Israel | 4428164 | |
| 139 | Policlinico Universitario Campus Bio-Medico /ID# 228917 | Rome | Lazio | Italy | 00128 |
| 140 | Ospedale San Raffaele IRCCS /ID# 228582 | Milan | Lombardia | Italy | 20132 |
| 141 | Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 228581 | Ancona | Italy | 60126 | |
| 142 | Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228583 | Palermo | Italy | 90127 | |
| 143 | Azienda USL di Reggio Emilia-IRCCS-Arcispedale Santa Maria Nuova /ID# 228734 | Reggio Emilia | Italy | 42121 | |
| 144 | Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 229899 | Nagoya-shi | Aichi | Japan | 455-8530 |
| 145 | Daido Clinic /ID# 229280 | Nagoya-shi | Aichi | Japan | 457-8511 |
| 146 | Sugimoto rheumatology and internal medicine clinic /ID# 229495 | Fukui-shi | Fukui | Japan | 910-0068 |
| 147 | National Hospital Organization Kyushu Medical Center /ID# 228642 | Fukuoka shi | Fukuoka | Japan | 810-8563 |
| 148 | Hamanomachi Hospital /ID# 228644 | Fukuoka-shi | Fukuoka | Japan | 810-8539 |
| 149 | Shono Rheumatism Clinic /ID# 229054 | Fukuoka-shi | Fukuoka | Japan | 814-0002 |
| 150 | Katayama Orthopedic Rheumatology Clinic /ID# 229277 | Asahikawa-shi | Hokkaido | Japan | 078-8243 |
| 151 | Sagawa Akira Rheumatology Clin /ID# 228787 | Sapporo-shi | Hokkaido | Japan | 060-0001 |
| 152 | Matsubara Mayflower Hospital /ID# 228948 | Kato-shi | Hyogo | Japan | 673-1462 |
| 153 | Sanuki Municipal Hospital /ID# 229276 | Sanuki-shi | Kagawa | Japan | 769-2393 |
| 154 | Bay Side Misato Medical Center /ID# 228947 | Kochi-shi | Kochi | Japan | 781-0112 |
| 155 | Kumamoto Orthopaedic Hospital /ID# 228641 | Kumamoto shi | Kumamoto | Japan | 8620975 |
| 156 | Medical Corporation Keiai Kai Clinic /ID# 228547 | Miyazaki-shi | Miyazaki | Japan | 880-0053 |
| 157 | Sasebo Chuo Hospital /ID# 229168 | Sasebo-shi | Nagasaki | Japan | 857-1195 |
| 158 | Nagaoka Red Cross Hospital /ID# 229962 | Nagaoka-shi | Niigata | Japan | 940-2085 |
| 159 | National Hospital Organization Osaka Minami Medical Center /ID# 229174 | Kawachinagano Shi | Osaka | Japan | 586-8521 |
| 160 | Osaka City General Hospital /ID# 228786 | Osaka-shi | Osaka | Japan | 534-0021 |
| 161 | Japanese Red Cross Osaka Hospital /ID# 229816 | Osaka-shi | Osaka | Japan | 543-8555 |
| 162 | Azuma Rheumatology Clinic /ID# 230078 | Sayama-shi | Saitama | Japan | 350-1305 |
| 163 | St.Luke's International Hospital /ID# 229492 | Chuo-ku | Tokyo | Japan | 104-8560 |
| 164 | National Hospital Organization Tokyo Medical Center /ID# 228720 | Meguro-ku | Tokyo | Japan | 152-8902 |
| 165 | Medical Corporation Uchida Clinic /ID# 229494 | Sumida-ku | Tokyo | Japan | 130-0013 |
| 166 | Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 228354 | Shimonoseki-shi | Yamaguchi | Japan | 752-0976 |
| 167 | SoonChunHyang University CheonAn Hospital /ID# 228146 | Cheonan-si | Chungcheongnamdo | Korea, Republic of | 31151 |
| 168 | Yonsei University Health System Severance Hospital /ID# 227659 | Seoul | Seoul Teugbyeolsi | Korea, Republic of | 03722 |
| 169 | Hanyang University Seoul Hospital /ID# 227658 | Seoul | Seoul Teugbyeolsi | Korea, Republic of | 04763 |
| 170 | Kyungpook National University Hospital /ID# 227657 | Daegu | Korea, Republic of | 41944 | |
| 171 | Inha University Hospital /ID# 227656 | Incheon | Korea, Republic of | 22332 | |
| 172 | Asan Medical Center /ID# 227655 | Seoul | Korea, Republic of | 05505 | |
| 173 | ZiekenhuisGroep Twente /ID# 229072 | Almelo | Netherlands | 7609 PP | |
| 174 | Academisch Medisch Centrum /ID# 227234 | Amsterdam | Netherlands | 1105 AZ | |
| 175 | Maastricht Universitair Medisch Centrum /ID# 227235 | Maastricht | Netherlands | 6229 HX | |
| 176 | Middlemore Clinical Trials /ID# 229012 | Papatoetoe | Auckland | New Zealand | 2025 |
| 177 | Timaru Medical Specialists Ltd /ID# 229013 | Timaru | Canterbury | New Zealand | 7910 |
| 178 | Wellington Regional Hospital /ID# 233517 | Newtown | Wellington | New Zealand | 6021 |
| 179 | Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 227939 | Bydgoszcz | Kujawsko-pomorskie | Poland | 85-168 |
| 180 | AMICARE Sp. z o.o. sp.k. /ID# 231327 | Lodz | Lodzkie | Poland | 90-644 |
| 181 | Duplicate_Centrum Medyczne Reuma Park /ID# 227170 | Warszawa | Mazowieckie | Poland | 02-691 |
| 182 | SANUS Szpital Specjalistyczny /ID# 227171 | Stalowa Wola | Podkarpackie | Poland | 37-450 |
| 183 | ClinicMed Daniluk, Nowak Sp.j. /ID# 227919 | Bialystok | Podlaskie | Poland | 15-879 |
| 184 | Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 228047 | Gdansk | Pomorskie | Poland | 80-546 |
| 185 | Medycyna Kliniczna /ID# 231133 | Warsaw | Poland | 00-874 | |
| 186 | GCM Medical Group PSC /ID# 228981 | San Juan | Puerto Rico | 00917-3104 | |
| 187 | Mindful Medical Research /ID# 228982 | San Juan | Puerto Rico | 00918-3756 | |
| 188 | Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 228755 | Moscow | Moskovskaya Oblast | Russian Federation | 129110 |
| 189 | LLC Family Outpatient Clinic № /ID# 227926 | Korolev | Moskva | Russian Federation | 141060 |
| 190 | Family Clinic /ID# 227929 | Yekaterinburg | Sverdlovskaya Oblast | Russian Federation | 620109 |
| 191 | Kazan State Medical University /ID# 227927 | Kazan | Tatarstan, Respublika | Russian Federation | 420012 |
| 192 | Central Clinical Hospital of Russian Academy of Science /ID# 229438 | Moscow | Russian Federation | 117593 | |
| 193 | Euromedservice /ID# 227933 | Pushkin | Russian Federation | 196603 | |
| 194 | Clinical Rheumatologic Hospital No 25 /ID# 227922 | St. Petersburg | Russian Federation | 190068 | |
| 195 | MEDMAN s.r.o. /ID# 227826 | Martin | Slovakia | 036 01 | |
| 196 | Reum.hapi s.r.o. /ID# 227825 | Nove Mesto nad Vahom | Slovakia | 915 01 | |
| 197 | Thermium s.r.o. /ID# 227816 | Piestany | Slovakia | 921 01 | |
| 198 | REUMAMED POPRAD s.r.o. /ID# 229628 | Poprad | Slovakia | 058 01 | |
| 199 | Reumex, s.r.o. /ID# 227827 | Rimavska Sobota | Slovakia | 979 01 | |
| 200 | Hospital Clínico Universitario de Santiago-CHUS /ID# 227420 | Santiago de Compostela | A Coruna | Spain | 15706 |
| 201 | Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 227666 | Sabadell | Barcelona | Spain | 08208 |
| 202 | Hospital Regional de Malaga /ID# 227418 | Málaga | Malaga | Spain | 29010 |
| 203 | Hospital Universitario Basurto /ID# 227667 | Bilbao | Vizcaya | Spain | 48013 |
| 204 | Hospital Universitario A Coruna - CHUAC /ID# 227419 | A Coruna | Spain | 15006 | |
| 205 | Hospital Universitario Fundacion Jimenez Diaz /ID# 234115 | Madrid | Spain | 28040 | |
| 206 | Hospital Universitario 12 de Octubre /ID# 227743 | Madrid | Spain | 28041 | |
| 207 | Hospital Universitario Virgen de Valme /ID# 227417 | Sevilla | Spain | 41014 | |
| 208 | Hospital Universitario y Politecnico La Fe /ID# 227408 | Valencia | Spain | 46026 | |
| 209 | Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 227220 | Chia-Yi | Taiwan | 62247 | |
| 210 | Far Eastern Memorial Hospital /ID# 227373 | New Taipei City | Taiwan | 22060 | |
| 211 | National Taiwan University Hospital /ID# 230001 | Taipei City | Taiwan | 100 | |
| 212 | Taipei Veterans General Hosp /ID# 227376 | Taipei City | Taiwan | 11217 | |
| 213 | Hacettepe Universitesi Tip Fak /ID# 227796 | Sihhiye | Ankara | Turkey | 06100 |
| 214 | Ankara Univ Medical Faculty /ID# 227797 | Ankara | Turkey | 06590 | |
| 215 | Kocaeli University Med Faculty /ID# 228244 | Kocaeli | Turkey | 41380 | |
| 216 | MNI City Multidisciplinary Hospital #18 /ID# 228961 | Kharkiv | Ukraine | 61110 | |
| 217 | Khmelnytskyi Regional Hospital /ID# 230680 | Khmelnytskyi | Ukraine | 29000 | |
| 218 | Medical Center of Medical Clinic Blagomed LLC /ID# 228956 | Kyiv | Ukraine | 01023 | |
| 219 | Medical Center "OK!Clinic+" /ID# 228958 | Kyiv | Ukraine | 02091 | |
| 220 | Medical Center CONSILIUM MEDICAL /ID# 228959 | Kyiv | Ukraine | 04050 | |
| 221 | PI "Poltava Regional Clinical Hospital n.a. M.V.Sklifosovsky" /ID# 228962 | Poltava | Ukraine | 36011 | |
| 222 | CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 228954 | Vinnytsia | Ukraine | 21028 | |
| 223 | Clinic of Scientific Research Institute of Invalid Rehabilitation /ID# 228955 | Vinnytsia | Ukraine | 21029 |
Sponsors and Collaborators
- AbbVie
Investigators
- Study Director: ABBVIE INC., AbbVie
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- M20-466
- 2020-005303-39