Relationship Between Strain and Stroke Volume in Cardiac Surgery

Sponsor

Tufts Medical Center (Other)

Overall Status

Recruiting

CT.gov ID

NCT04694378

Collaborator

(none)

Enrollment

Location

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Patients undergoing coronary artery bypass grafting up tp 30% will develop postoperative right ventricle dysfunction. Its imperative for the physician to fully understand the severity of this complication in order to perform an early diagnosis and carry out the appropriate treatment.

Aim:

Investigate the correlation between echocardiographic measurements and hemodynamic changes at different time points in patients undergoing coronary artery bypass graft surgery

Hypothesis:

Weak correlation between echocardiographic measurements and hemodynamic changes during coronary artery bypass graft surgery
Echocardiographic measurements would change across different time points during surgery independent of hemodynamic values.

Condition or Disease	Intervention/Treatment	Phase
Right Ventricular Dysfunction Stroke Volume Index Longitudinal Heart Strain

Study Design

Study Type:

Observational [Patient Registry]

Anticipated Enrollment :

50 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Relationship Between Right Ventricular Free Wall Longitudinal Strain and Stroke Volume Index by Thermodilution in Patients Undergoing Cardiac Surgery

Actual Study Start Date :

Oct 1, 2020

Anticipated Primary Completion Date :

Jul 1, 2022

Anticipated Study Completion Date :

Oct 31, 2022

Outcome Measures

Primary Outcome Measures

Change of right ventricular function during CABG assessed by right heart strain (%) [during CABG surgery]
Assessing the change of RV function during CABG surgery using right heart strain as a percentage of change between RV shortening and RV end diastolic length.
Change of right ventricular function during CABG assessed by stroke volume index (mL/m2) [during CABG surgery]
Assessing the change of RV function during CABG surgery using stroke volume index. Stroke volume index measurement as millilitres per square meter (ml/m2)

Secondary Outcome Measures

Change in cardiac output measured with Swan-Ganz during CABG [during CABG surgery]
Cardiac output (L/min) measured with the thermodilution technique

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Elective coronary artery bypass graft patients who require pulmonary catheter placement for intraoperative monitoring.

Exclusion Criteria:

Patients with contraindication to Swan-Ganz catheter placement,
Pre-existing atrial arrhythmias,
Patients with moderate and/or severe mitral/tricuspid valve stenosis or regurgitation
Patients with contraindication to transesophageal echocardiogram probe placement (i.e. esophageal stenosis).