Risk Factors Associated With Infection After Spine Surgery
Study Details
Study Description
Brief Summary
Surgical site infection (SSI), particularly deep SSI, is one of the most serious complications after spinal surgery. evaluating the risk of SSI and, correspondingly, prescription of prophylactic measures are extremely important to prevent SSI and avoid potentially devastating consequences. A retrospective study was conducted aiming to develop a point-based prediction model of deep surgical site infection in patients receiving open posterior instrumented thoracolumbar surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Data of 3,419 patients in 4 hospitals from Jan 1, 2012 to Dec 30, 2021 were retrospectively collected and were evaluated aiming to develop a point-based prediction model of deep surgical site infection in patients receiving open posterior instrumented thoracolumbar surgery. Clinical knowledge-driven, data-driven and decision tree model was used to identify predictive variables of deep SSI. Internal validation was performed by using bootstrapping methods.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| patients who developed deep surgical site infection after thoracolumbar surgery this group included patients who developed deep surgical site infection after open posterior instrumented thoracolumbar surgery |
Procedure: open posterior instrumented thoracolumbar surgery
Both group previously received open posterior instrumented thoracolumbar surgery in 4 centers
|
| patients who did not develop deep surgical site infection after thoracolumbar surgery this group included patients who did not develop deep surgical site infection after open posterior instrumented thoracolumbar surgery |
Procedure: open posterior instrumented thoracolumbar surgery
Both group previously received open posterior instrumented thoracolumbar surgery in 4 centers
|
Outcome Measures
Primary Outcome Measures
- deep surgical site infection [within 30 days after the operation]
deep SSI was defined as an infection occurring within 30 days after the operation involving deep soft tissues along with one of the following criterion: (1)purulent drainage from the deep incision but not from the organ/space component of the surgical site;(2) a deep incision spontaneously dehisces or is deliberately opened by a surgeon when the patient has at least one of the following signs or symptoms: fever >38℃, localized pain, or tenderness, unless site is culture-negative;(3) an abscess or other evidence of infection involving the deep incision is found on direct examination, during reoperation, or by histopathologic or radiologic examination;(4) diagnosis of a deep incisional SSI by a surgeon or attending physician. In this study, organ space SSI was also classified as deep SSI due to the same criteria as deep SSI.
Eligibility Criteria
Criteria
Inclusion Criteria:
patients who previously received open posterior instrumented thoracolumbar surgery
Exclusion Criteria:
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were aged < 18 years;
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underwent surgery for the spinal infection, spine revision surgery, or cervical operation;
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were diagnosed as superficial SSI;
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died in hospital;
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diagnosis of SSI was not determined;
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had missing data more than 10% were excluded.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University | Beijing | China | 100053 |
Sponsors and Collaborators
- Xuanwu Hospital, Beijing
Investigators
- Study Director: Fengzeng Jian, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Neurospine_infection