Risk Factors for Barotrauma in COVID-19
Study Details
Study Description
Brief Summary
Barotrauma in mechanical ventilation (MV) is defined as lung damage attributable to the application of high airway pressure and is one of the potential mechanisms of ventilator-induced lung injury (VILI). Previous studies have shown an increased mortality in patients with barotrauma under MV; pneumothorax (PTX) being the most common presentation, but it can also present as pneumomediastinum (PM) with or without PTX, with extension to soft tissue as subcutaneous emphysema or even as pneumo-retroperitoneum and pneumo-scrotum.
Traditionally, underlying lung disease or age are known risk factors for non-trauma related barotrauma. However, in patients with novel coronavirus disease (COVID-19), the incidence of this complication is more common than in non-infected patients, as recently reported. Since little is known regarding which are the main risk factors for these events to develop, most pathophysiological mechanisms remain unexplained.
The aim of this study was to determine the risk factors for developing barotrauma in patients under MV with COVID-19 associated Acute Respiratory Distress Syndrome (ARDS). Secondary objectives were to determine the incidence of barotrauma and its association with mortality.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Barotrauma/cases Cases were defined as patients with barotrauma consulted with the Surgery Department |
Other: No intervention
No intervention
|
| No braotruma/Controls Controls were selected from a random sample of the COVID-19-ARDS cohort. |
Other: No intervention
No intervention
|
Outcome Measures
Primary Outcome Measures
- Barotrauma development [During patient hospitalization, an average of one month]
Diagnosis of barotrauma in patients under mechanical ventilation with COVID-19 associated Acute Respiratory Distress Syndrome
Secondary Outcome Measures
- Mortality [During patient hospitalization, an average of one month]
Dead of patient
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients under MV fulfilling the Berlin definition for ARDS, with positive SARS-COV2 real time polymerase chain reaction
Exclusion Criteria:
- Incomplete clinical records and other causes of extrapulmonary air
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital General Ajusco Medio | Mexico city | Mexico | 14250 |
Sponsors and Collaborators
- Hospital General Ajusco Medio
- Horacio Marquez-Gonzalez
- Carlos Torruco-Sotelo
- Sebastian Rodriguez-Llamazares
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HGAM01