Risk Factors for Exertional Heat Illness
Study Details
Study Description
Brief Summary
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI).
The aim of this study is to examine traditional and novel risk factors that may increase thermal strain and EHI likelihood in military recruits undergoing strenuous physical exercise.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Exertional heat illness Participants who experience an atypical elevation in thermal strain or an EHI undergoing strenuous physical exercise. |
Other: Core temperature monitoring
Core temperature will be monitored on the day of exercise
Behavioral: Questionnaires
Questionnaires will be completed at baseline and on the day of exercise
Other: Heart rate monitoring
Heart rate will be monitored on the day of exercise
Other: Urine collection
Urine samples will be collected at baseline and on the day of exercise
Other: Sleep monitoring
Sleep will be monitored at baseline and on the day of exercise
Other: Blood collection
Blood samples will be completed at baseline
Other: Saliva collection
Saliva samples will be collected at baseline and on the day of exercise
Other: Throat swab collection
Throat swab samples will be collected at baseline and on the day of exercise
Other: Stool collection
Stool samples will be collected at baseline and on the day of exercise
|
| Control Participants who do not experience an atypical elevation in thermal strain or an EHI undergoing strenuous physical exercise. |
Other: Core temperature monitoring
Core temperature will be monitored on the day of exercise
Behavioral: Questionnaires
Questionnaires will be completed at baseline and on the day of exercise
Other: Heart rate monitoring
Heart rate will be monitored on the day of exercise
Other: Urine collection
Urine samples will be collected at baseline and on the day of exercise
Other: Sleep monitoring
Sleep will be monitored at baseline and on the day of exercise
Other: Blood collection
Blood samples will be completed at baseline
Other: Saliva collection
Saliva samples will be collected at baseline and on the day of exercise
Other: Throat swab collection
Throat swab samples will be collected at baseline and on the day of exercise
Other: Stool collection
Stool samples will be collected at baseline and on the day of exercise
|
Outcome Measures
Primary Outcome Measures
- Body mass index in EHI and control group [Baseline]
- Fitness in EHI and control group - participants ranked by time to complete fitness test [Baseline]
- Core temperature in EHI and control group [1 Day]
- Heart rate in EHI and control group [2 Hours]
- Urine osmolality in EHI and control group [Baseline]
- Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index, in EHI and control group [Throughout study - up to 1 week]
0-21 Scale. Higher score indicates worse outcome
- Sleep quality, measured by actigraphy, between EHI and control group [Throughout study - up to 1 week]
- Sleep quantity, measured by actigraphy, between EHI and control group [Throughout study - up to 1 week]
- Circulating Interleukin 6 in EHI and control group [Baseline]
- Circulating C-Reactive Protein in EHI and control group [Baseline]
- Circulating Creatine kinase in EHI and control group [Baseline]
- Circulating Aspartate Aminotransferase in EHI and control group [Baseline]
- Circulating Alanine Aminotransferase in EHI and control group [Baseline]
- Circulating Claudin 3 in EHI and control group [Baseline]
- Circulating Zonulin in EHI and control group [Baseline]
- Circulating Lipopolysaccharide binding protein in EHI and control group [Baseline]
- Circulating immunoglobulin E in EHI and control group [Baseline]
- Salivary cortisol in EHI and control group [Throughout study - up to 1 week]
- Detection of infectious pathogens in EHI and control groups [Throughout study - up to 1 week]
- Respiratory illness symptomology, measured by Jackson common cold questionnaire, in EHI and control group [Throughout study - up to 1 week]
0-24 Scale. Higher score indicates worse outcome
- Gastrointestinal illness symptomology, measured by gastrointestinal symptoms questionnaire, in EHI and control group [Throughout study - up to 1 week]
0-10 Scale per symptom. Higher score indicates worse outcome
- Abundance and diversity of gastrointestinal microbiota in EHI and control group [Baseline]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Men and women aged 17-35 years enrolled in military training
Exclusion Criteria:
- Self-report as pregnant
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Commando Training Centre Royal Marine | Lympstone | Devon | United Kingdom | EX8 5AR |
Sponsors and Collaborators
- Liverpool John Moores University
- Institute of Naval Medicine (UK)
- CTCRM Lympstone (UK)
- University of Portsmouth (UK)
- Public Health Wales (UK)
- Bangor University (UK)
- Headquarters Army Recruiting and Initial Training Command (UK)
- Defence Science and Technology (UK)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2029/MODREC/21