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Risk Indicators in Patients With Ventricular Fibrillation During Acute Myocardial Infarction

Sponsor
Heidelberg University (Other)
Overall Status
Unknown status
CT.gov ID
NCT00175942
Collaborator
(none)
300
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Sudden cardiac death is in most cases triggered by ischemia-related ventricular tachyarrhythmias and accounts for 50% of deaths from cardiovascular disease in developed countries. Chronic elevation of indicators of coagulation activation has been found in patients with coronary heart disease , but a role of coagulation activation and proinflammatory state as a potential risk factor for ventricular fibrillation (VF) during acute myocardial infarction has not been investigated.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Sudden cardiac death (SCD) is in most cases triggered by ischemia-related ventricular arrhythmias and is responsible for 50% of the mortality from cardiovascular disease in developed countries (1). Chronic elevation of indicators of coagulation activation and inflammation has been found in patients with coronary heart disease and may contribute to vasculatory disorders probably contributing to the development of arrhythmogenesis. However, the role of coagulation activation as a potential risk factor for ventricular fibrillation during acute myocardial infarction has not been investigated yet.

    Study Design

    Study Type:
    Observational
    Observational Model:
    Defined Population
    Time Perspective:
    Other
    Official Title:
    Indicators of Coagulation Activation and Inflammation Contributing to Ventricular Fibrillation Complicating Acute Myocardial Infarction
    Study Start Date :
    Feb 1, 2003

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      0 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      ST-elevation myocardial infarction ventricular fibrillation during acute MI

      Exclusion Criteria:

      NSTEMI coagulation disorders, e.g.intake of coumadin

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 University Hospital of Mannheim, University of Heidelberg Mannheim Germany 68167

      Sponsors and Collaborators

      • Heidelberg University

      Investigators

      • Principal Investigator: Carl E. Dempfle, Prof.Dr., University Hospital of Mannheim, University of Heidelberg

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00175942
      Other Study ID Numbers:
      • 0229.3
      First Posted:
      Sep 15, 2005
      Last Update Posted:
      Sep 15, 2005
      Last Verified:
      May 1, 2005
      Keywords provided by , ,
      acute myocardial infarction
      ventricular fibrillation
      coagulation
      inflammation
      Additional relevant MeSH terms:
      Myocardial Infarction
      Death, Sudden, Cardiac
      Ventricular Fibrillation
      Infarction
      Death

      Study Results

      No Results Posted as of Sep 15, 2005