Risk Factors for Progressive Supranuclear Palsy (PSP)

Sponsor

University of Louisville (Other)

Overall Status

Completed

CT.gov ID

NCT00431301

Collaborator

National Institute on Aging (NIA) (NIH)

942

Enrollment

Locations

Duration (Months)

94.2

Patients Per Site

1.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement disorder. This study will determine the role of specific genetic, occupational and environmental components in the development of PSP by evaluating patients with this disorder and age and gender matched controls.

Condition or Disease	Intervention/Treatment	Phase
Progressive Supranuclear Palsy

Detailed Description

This proposal will determine: (1) if there is an association between PSP and specific genes of interest; (2) if there is an association between PSP and occupational and/or environmental chemical exposures functionally or structurally similar to known parkinsonian toxicants; and (3) if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP. To disentangle the complex etiology of PSP, this case-control multicenter study involves 500 PSP cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic confirmation. Understanding the etiology of PSP may also help explain the causes of other related diseases such as Alzheimer's disease. This multidisciplinary team of movement disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist and toxicologist is well suited to unravel the etiology of PSP.

Study Design

Study Type:

Observational

Actual Enrollment :

942 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Genetic and Environmental Risk Factors for PSP

Study Start Date :

Aug 1, 2006

Actual Primary Completion Date :

Feb 1, 2013

Actual Study Completion Date :

Jun 1, 2013

Arms and Interventions

Arm	Intervention/Treatment
Case PSP Cases
Control Healthy Controls

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

40 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

PSP patients able to visit one of the screening sites for diagnostic confirmation and able to participate in a one hour telephone interview

Exclusion Criteria:

No other major neurological disorders
Unable to communicate by telephone

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama, Birmingham	Birmingham	Alabama	United States	35233
2	UCLA	Los Angeles	California	United States	90095-1759
3	University of Colorado	Aurora	Colorado	United States	80045
4	Emory College of Medicine	Atlanta	Georgia	United States	30322
5	Rush University	Chicago	Illinois	United States	60611
6	University of Kansas	Kansas City	Kansas	United States	66160
7	University of Louisville	Louisville	Kentucky	United States	40202
8	University of Maryland	Baltimore	Maryland	United States	21201
9	Case Western University	Cleveland	Ohio	United States	44106
10	University of Toronto	Toronto	Ontario	Canada	M5T 2S8