Risk Factors for Recurrent Urinary Tract Infection in Children

Sponsor

Kaunas University of Medicine (Other)

Overall Status

Completed

CT.gov ID

NCT00528476

Collaborator

(none)

161

Enrollment

Location

Duration (Months)

6.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to determine clinical and urodynamic risk factors for recurrent urinary tract infection in 5-18 years old children.

Condition or Disease	Intervention/Treatment	Phase
Urinary Tract Infection Pyelonephritis Cystitis

Detailed Description

It is known, that in the group of young children the most common reason of recurrent UTI is anatomic abnormalities, such as vesicoureteral reflux, hydronephrosis. However, not all recurrent UTI can be explained by anatomic abnormalities. The vast majority of school age children with recurrent UTI have anatomically normal urinary tract. Recent studies discuss about the role of behavioral and functional abnormalities (inadequate fluid intake, stool retention, infrequent voiding, etc.) that can predispose recurrent urinary tract infections. Influence of some these abnormalities for recurrent UTI is controversial. Family history, behavioral and functional abnormalities which predispose to urinary tract infections in children with normal urinary tract are neglected in most protocols of urinary tract infection.

Children in this study receive a careful evaluation including complete history, voiding-drinking diary, bowel questionnaire, physical investigation, sonography, voiding cystourethrogram.

Follow up time - 1 year. Urinalysis once a month and during each episode of fever.

Study Design

Study Type:

Observational

Actual Enrollment :

161 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Role of Clinical and Urodynamic Risk Factors for Recurrent Urinary Tract Infection in 5-18 Years Old Children

Study Start Date :

Nov 1, 2004

Actual Study Completion Date :

Jan 1, 2007

Arms and Interventions

Arm	Intervention/Treatment
1 Patients, who were treated because of recurrent (2 or more urinary tract infections per year) pyelonephritis or cystitis.
2 Patients with nonrecurrent urinary tract infections (patients who had no history of more than one urinary tract infections in last year).

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

5 Years to 18 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

5-18 years old children, who were treated because of cystitis and pyelonephritis in Kaunas Medical University Hospital

Exclusion Criteria:

urinary tract malformations
neurogenic bladder dysfunction
patients, who received immunosuppressive drugs
pregnant girls
children with non bacterial urinary tract infection

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Kaunas University of Medicine	Kaunas		Lithuania	44307

Sponsors and Collaborators

Kaunas University of Medicine

Investigators

Principal Investigator: Sarunas Rudaitis, MD, Clinic of Children's Diseases, Kaunas University of Medicine
Study Chair: Birute Pundziene, MD, PhD, Clinic of Children's Diseases, Kaunas University of Medicine