Risk Taking and Fracture Study
Study Details
Study Description
Brief Summary
Boys suffer a disproportionately large number of fractures compared to girls (55-60%). This study aims to determine why this is the case by identifying risk factors for wrist fractures. The increase in fracture during childhood and adolescence may be associated with 1) risk-taking behaviour in boys, 2) obesity trends in boys during childhood and adolescence, and/or 3) impaired acquisition of bone strength during childhood and adolescence. Importantly from a knowledge translation perspective, modifiable factors such as behaviour, dietary habits or physical activity in boys may predict fracture.
The investigators will measure 400 children (100 girls and 100 boys who have sustained a fracture; 100 same age and sex friends) across 4 years of growth. This study will assess risk behaviours, diet, physical activity, motor proficiency (i.e., balance and coordination), fat and muscle mass and bone strength to determine if there are, 1) differences in whether all or some of these factors predict fractures in boys compared with girls and, 2) whether these factors track forward similarly in boys compared with girls as children advance through the growth spurt.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The investigators aim to better characterize factors that contribute to fracture in boys and girls and to assess whether such factors track across a four year period. The innovation is to use novel methods and an integrated approach, to measure the influence of risk-taking behaviour, body composition, bone microstructure, motor proficiency, diet and physical activity in one model across growth. This will provide a more comprehensive picture of the key multi-factorial predictors of fracture within- and between-sexes. This essential information will provide the basis for change in public health policy, clinical practice, community programs, and targeted interventions.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Fracture - Boys Boys who have sustained a distal radius fracture |
Other: Fracture - Boys
Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years
|
| Fracture - Girls Girls who have sustained a distal radius fracture |
Other: Fracture - Girls
Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years
|
| Non Fracture - Boys Boys who have not sustained a distal radius fracture |
Other: Non Fracture - Boys
Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years
|
| Non Fracture - Girls Girls who have not sustained a distal radius fracture |
Other: Non Fracture - Girls
Annual measurements of risk taking behaviour, body composition, bone microstructure, balance, diet, and physical activity over 4 years
|
Outcome Measures
Primary Outcome Measures
- Characterization of factors that contribute to fractures in boys and girls [Baseline (<3 months after injury)]
The factors include: Risk taking behaviour - protection motivation variables, anticipated regret and excitement and impulsivity dispositions Body composition - total body mass, fat mass, lean mass Bone microstructure - cortical and trabecular bone outcomes Dietary intake - calcium Physical activity
Secondary Outcome Measures
- Tracking of Risk Factors [4 years]
The outcomes will be measured across a 3 year interval (4 years in total) to determine whether factors track similarly in boys compared with girls over time and to assess their continued (or not) contribution to fracture.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Boys aged 9-15 and Girls aged 8-13
-
Fracture to distal radius after low to moderate energy trauma
-
No other health concerns
-
Healthy (non fracture) subjects for comparison
Exclusion Criteria:
-
Fracture is a result of severe trauma
-
Children with ontological medical conditions
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centre for Hip Health and Mobility | Vancouver | British Columbia | Canada | V5Z 1M9 |
| 2 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
Sponsors and Collaborators
- Canadian Institutes of Health Research (CIHR)
Investigators
- Principal Investigator: Heather McKay, PhD, Centre for Hip Health and Mobility
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H10-00044