The Risk Factors of Thrombosis in Complicated Arteriovenous Fistula

Assiut University (Other)
Overall Status
Not yet recruiting ID

Study Details

Study Description

Brief Summary

study the risk factors of thrombosis in thrombosed arteriovenous fistula in patients on regular hemodialysis

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The number of patients being treated for kidney failure continues to increase every year at a significantly higher rate than that of the world population.

    The main renal replacement therapy was hemodialysis (HD) in 57% patients and peritoneal dialysis in 5% patients, while 37% patients underwent a functional kidney transplant.

    Native arteriovenous fistula (AVF) is currently the best VA when technically feasible, according to the international dialysis guidelines.

    Hemodialysis vascular access failure is the dominant cause of morbidity and the major cost of care for end-stage renal disease (ESRD) patients .

    Complications such as thrombosis of VA remain the main problem for many patients with kidney failure.

    Since 1994, prospective and case-control studies have explored the relationship between risk factors and arteriovenous fistula thrombus (AVFT) in patients undergoing HD .

    Until now, these studies and reviews have revealed that numerous risk factors are associated with AVFT .

    Risk factors like arterio-venous graft, age, female sex, C-reactive protein level, fistula site (distal), hypertension and the use of eprex can be associated with AVFT, and this knowledge advances the understanding of AVFT, facilitates multivariable risk prediction profiling, and lays the foundation for future preventive strategies .

    Study Design

    Study Type:
    Anticipated Enrollment :
    69 participants
    Observational Model:
    Time Perspective:
    Official Title:
    The Risk Factors of Thrombosis in Complicated Arteriovenous Fistula in Patients on Regular Hemodialysis
    Anticipated Study Start Date :
    Dec 1, 2023
    Anticipated Primary Completion Date :
    Dec 1, 2024
    Anticipated Study Completion Date :
    Jan 1, 2025

    Outcome Measures

    Primary Outcome Measures

    1. Detection of the risk factors of thrombosis in complicated AV Fistula in patients on regular hemodialysis [1 week following AV Fistula occlusion]

      Provide the evidence on the association between potential risk factors and arteriovenous fistula thrombus

    Eligibility Criteria


    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    Inclusion Criteria:
    • All patients on maintenance hemodialysis treatment at the dialysis unit of the department of nephrology in Assiut University Hospital .
    Exclusion Criteria:
    • Patients with known other risk factors of thrombosis, e.g., malignancy, pregnancy, cocs and nephrotic syndrome.

    Contacts and Locations


    No locations specified.

    Sponsors and Collaborators

    • Assiut University


    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information


    Responsible Party:
    Mohamed Aldosouky, Resident doctor, Assiut University Identifier:
    Other Study ID Numbers:
    • AV fistula thrombosis
    First Posted:
    Jul 27, 2023
    Last Update Posted:
    Jul 27, 2023
    Last Verified:
    Jul 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    Studies a U.S. FDA-regulated Device Product:
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Jul 27, 2023