The Robot-Assisted Laparoscopic Radical Prostatectomy Combined Anterior and Posterior Approach
Study Details
Study Description
Brief Summary
The goal of this observational study was to compare the perioperative outcomes, postoperative urinary control rates and positive surgical margin (PSM) rates of the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach (AP-RARP) with the Retzius-sparing approach (RS-RARP) and anterior approach (anterior-RARP) in the treatment of prostate cancer. The main question it aims to answer was:
• The early therapeutic efficacy of the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach
Participants has been underwent:
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AP-RARP
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RS-RARP
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anterior-RARP Researchers compared the three groups to see if AP-RARP combines the advantages of anterior and posterior RARP and is a feasible surgical option for the treatment of prostate cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| AP-RARP the robot-assisted laparoscopic radical prostatectomy combined anterior and posterior approach |
Procedure: the robot-assisted laparoscopic radical prostatectomy
We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.
|
| RS-RARP the robot-assisted laparoscopic radical prostatectomy with the Retzius-sparing approach |
Procedure: the robot-assisted laparoscopic radical prostatectomy
We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.
|
| anterior-RARP he robot-assisted laparoscopic radical prostatectomy with anterior approach |
Procedure: the robot-assisted laparoscopic radical prostatectomy
We collect medical data of 233 patients with clinically localized prostate cancer who underwent AP-RARP, RS-RARP or anterior-RARP. Perioperative outcomes, including operation time, intraoperative blood loss, intraoperative and postoperative transfusion, postoperative infection, and anastomotic leakage, were compared among the three groups. The postoperative continence rates and PSM rates were also compared.
|
Outcome Measures
Primary Outcome Measures
- urinary continence [0-6 month after surgery]
was defined as using 0-1 pad a day
- positive surgical margin [2 weeks after surgery]
observed whether the tissue cutting in surgery has tumor cell in surgical margin by pathologist
Secondary Outcome Measures
- operating time [the day of the surgery]
The start time of the operation refers to the time of incision of the skin at the surgical site. The end time of surgery refers to the time when the skin is sutured.
- intraoperative blood loss [the day of the surgery]
Intraoperative bleeding was defined as the sum of blood content in blood gauze, blood content in negative pressure suction bottle and blood clot volume.
Eligibility Criteria
Criteria
Inclusion Criteria:
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pathologically diagnosed with prostate cancer by prostate biopsy
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underwent robot-assisted laparoscopic surgery
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the surgery performed by Weidong Gan
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the extended pelvic lymphadenectomy (PLA) is performed on patients with high-risk prostate cancer (PSA≥20 ng/ml or Grade Group 4-5 or clinical stage ≥T2c) and those considered to have a possibility of lymph node metastasis based on imaging evaluation.
Exclusion Criteria:
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Patients with a clinical and pathological TNM stage ≥T3b and N1
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patients with distant metastasis
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urinary incontinence before surgery
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received neoadjuvant therapy before surgery
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School | Nanjing | Jiangsu | China | 210008 |
Sponsors and Collaborators
- Nanjing University School of Medicine
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NanjingUSM202388