Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium
Study Details
Study Description
Brief Summary
As a medium-and long-term non-depolarizing muscle relaxant, rocuronium has the advantages of quick effect, no histamine release and accumulation and no obvious cardiovascular adverse reactions, so it has been widely used in clinical anesthesia induction. However, when given intravenously, rocuronium can cause adverse reactions such as injection pain and limb retraction, which can lead to needle prolapse, extravasation of injection drugs, swelling of injection site, serious induction delay, and cardiovascular adverse events in severe cases. Remifentanil is a synthetic opioid drug hydrolyzed by esterase. Compared with other opioid drugs, remifentanil has the advantages of quick effect, short half-life and short time of hemodynamic changes, so it is an ideal analgesic in clinical anesthesia. In this study, in order to provide clinical references, sequential method was used to find the median effective dose (ED50) by means of pre-intravenous injection of Remifentanil to suppress pain in rocuronium injection.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Age range of 18 to 44 years olds The initial dose of lidocaine for pre-injection was set at 1ug/kg according to previous literature and preliminary test results. The dose of remifentanil was according to the patients' pain level. If there is no pain (negative reaction), the dose of remifentanil in the next patient will be reduced until the patient has pain. If there is pain (positive reaction), the dose of remifentanil will be increased in the next patient until the patient is painless. |
Drug: Remifentanil
Advanced intravenous injection of remifentanil before the rocuronium injection
|
| Experimental: Age range of 45 to 59 years olds The initial dose of lidocaine for pre-injection was set at 1ug/kg according to previous literature and preliminary test results. The dose of remifentanil was according to the patients' pain level. If there is no pain (negative reaction), the dose of remifentanil in the next patient will be reduced until the patient has pain. If there is pain (positive reaction), the dose of remifentanil will be increased in the next patient until the patient is painless. |
Drug: Remifentanil
Advanced intravenous injection of remifentanil before the rocuronium injection
|
| Experimental: Age range of 60 to 80 years olds The initial dose of lidocaine for pre-injection was set at 1ug/kg according to previous literature and preliminary test results. The dose of remifentanil was according to the patients' pain level. If there is no pain (negative reaction), the dose of remifentanil in the next patient will be reduced until the patient has pain. If there is pain (positive reaction), the dose of remifentanil will be increased in the next patient until the patient is painless. |
Drug: Remifentanil
Advanced intravenous injection of remifentanil before the rocuronium injection
|
Outcome Measures
Primary Outcome Measures
- The appearance of intravenous injection pain Yes or No [an average of 2 minutes]
Yes or No
Secondary Outcome Measures
- The levels of intravenous injection pain [an average of 2 minutes]
The intravenous injection pain in this study was divided into the following 5 levels according to its severity: level 0: After repeated questioning, the patient did not feel any abnormal sensation; level 1: upon inquiry, the patient felt swelling at the intravenous injection site; Level 2: Upon inquiry, the patient felt pain and had no body movement reaction (facial pain expression, arm withdrawal, tears, etc.); Level 3: Upon inquiry, the patient had pain and body movement reaction. Or complain of pain without inquiry; Level 4: the patient has a strong reaction and body movement reaction. Level 2 and above is defined as injection pain.
Other Outcome Measures
- If any adverse memory or pain during the induction of general anesthesia [the time one hour after turn into Postanesthesia care unit]
Patients recalled by visual analogue scale (VAS) to assess injection pain level : Mark 0 is painless. Mark 10 is violent pain, The numbers between them was pain of varying degrees.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Ages ranged from 18 to 80.
-
ASA # or # level.
Exclusion Criteria:
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Allergy or contraindication to remifentanil or rocuronium; required for Central venipuncture catheterization;
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Abnormal liver or kidney function;
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Heavy drinking and long-term use of sedatives, analgesics or anti-anxiety drugs;
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Hearing and language impairment;
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Peripheral vascular disease;
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Severe cardiovascular disease or neurological disorders;
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Failure of one-time peripheral venipuncture;
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Infection of hand or wrist skin.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | the Affiliated Hospital of Yangzhou University | Yangzhou | Jiangsu | China | 225000 |
Sponsors and Collaborators
- Yangzhou University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20211218