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Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

Sponsor
National Center for Research Resources (NCRR) (NIH)
Overall Status
Unknown status
CT.gov ID
NCT00008749
Collaborator
Arthritis Foundation (Other)
1
Location

Study Details

Study Description

Brief Summary

Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Case-Control
    Official Title:
    Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      13 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion:

      A diagnosis of systemic lupus erythematosus

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Children's Hospital of Philadelphia Philadelphia Pennsylvania United States 19104-4318

      Sponsors and Collaborators

      • National Center for Research Resources (NCRR)
      • Arthritis Foundation

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00008749
      Other Study ID Numbers:
      • NCRR-M01RR00240-1736
      First Posted:
      Jan 18, 2001
      Last Update Posted:
      Jun 24, 2005
      Last Verified:
      Dec 1, 2003
      Additional relevant MeSH terms:
      Lupus Erythematosus, Systemic

      Study Results

      No Results Posted as of Jun 24, 2005