Role of B2 Adrenergic Receptors in Labor Pain

• Sponsor: Columbia University (Other)
• Overall Status: Completed
• CT.gov ID: NCT00385294
• Collaborator: (none)
• Enrollment: 150
• Location: 1
• Duration (Months): 28
• Patients Per Site Per Month: 5.4

Study Details

Study Description

Brief Summary

The study aims to understand why labor is more painful for some women compared to others. The study will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.

Condition or Disease	Intervention/Treatment	Phase
Pain; Pain Threshold; Labour Pain

Detailed Description

Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. The study will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. The investigators will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.

Study Design

• Study Type: Observational
• Actual Enrollment: 150 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Role of B2 Adrenergic Receptors in Labor Pain
• Study Start Date: Sep 1, 2006
• Actual Primary Completion Date: Jan 1, 2009
• Actual Study Completion Date: Jan 1, 2009

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 40 Years
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• nulliparous women

• Third trimester of pregnancy on enrollment

Exclusion Criteria:

• Chronic Pain

• Pain medication utilization

• Large for gestational age baby

• Small for gestational age baby

• Systemic illness

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Columbia University	New York	New York	United States	10032

Sponsors and Collaborators

• Columbia University

Investigators

• Principal Investigator: Pamela D. Flood, M.D., Columbia University

Study Documents (Full-Text)

None provided.

More Information

Publications

• Hsu YW, Somma J, Hung YC, Tsai PS, Yang CH, Chen CC. Predicting postoperative pain by preoperative pressure pain assessment. Anesthesiology. 2005 Sep;103(3):613-8.
• Liang DY, Liao G, Wang J, Usuka J, Guo Y, Peltz G, Clark JD. A genetic analysis of opioid-induced hyperalgesia in mice. Anesthesiology. 2006 May;104(5):1054-62.

• Responsible Party: Pamela Flood, Professor of Anesthesiology, Columbia University
• ClinicalTrials.gov Identifier: NCT00385294
• Other Study ID Numbers: AAAB3535
• First Posted: Oct 9, 2006
• Last Update Posted: Jul 18, 2018
• Last Verified: Jul 1, 2018

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Pamela Flood, Professor of Anesthesiology, Columbia University: Genetic; pain; obstetrical
• Additional relevant MeSH terms: Labor Pain

Study Results

No Results Posted as of Jul 18, 2018