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Role of CCL2 in Alcoholic Liver Diseases

Sponsor
Erasme University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01128010
Collaborator
(none)

Study Details

Study Description

Brief Summary

Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective

    Arms and Interventions

    Arm Intervention/Treatment
    alcoholic liver disease

    alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution
    controls

    Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes

      ALD patients

      Inclusion Criteria:

      • Excess alcohol intake

      • Abnormality of liver biopsy compatible with alcoholic aetiology

      • Caucasian ethnicity

      Exclusion Criteria:

      • Presence of any other chronic liver disease

      • co-infection with HIV Controls Inclusion criteria

      • Caucasian ethnicity

      • presence of a disease

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • Erasme University Hospital

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT01128010
      Other Study ID Numbers:
      • DD-CCL2
      First Posted:
      May 21, 2010
      Last Update Posted:
      May 21, 2010
      Last Verified:
      Dec 1, 2002
      Additional relevant MeSH terms:
      Liver Diseases
      Liver Diseases, Alcoholic

      Study Results

      No Results Posted as of May 21, 2010