THY-ED: Role of Endocrine Disruptors in Thyroid Cancer
Study Details
Study Description
Brief Summary
the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS).
The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Case group Patients with thyroid cancer diagnosis within 5 years before study enrollment |
Diagnostic Test: Blood and urine diagnostic evaluation
Blood and urine samples will be obtained from both case and control groups in order to evaluate EDCs concentrations
|
| Control group Patients without clinical diagnosis of thyroid disease |
Diagnostic Test: Blood and urine diagnostic evaluation
Blood and urine samples will be obtained from both case and control groups in order to evaluate EDCs concentrations
|
Outcome Measures
Primary Outcome Measures
- Difference in the average levels of the main endocrine disruptors [At recruitment]
The main endocrine disruptors evaluated will be PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants
- Relationship between the concentrations of endocrine disruptors and anamnestic variables [At recruitment]
Relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).
Eligibility Criteria
Criteria
Inclusion Criteria:
-
patients with a diagnosis of thyroid cancer in the last 5 years (arm A)
-
patients without a diagnosis of thyroid cancer will match patients included in arm A
Exclusion Criteria:
-
subjects under 18 years old
-
patients unable to sign the informed consent or questionnaires
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Istituto Auxologico Italiano, IRCCS | Milan | Italy | 20149 |
Sponsors and Collaborators
- Istituto Auxologico Italiano
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 05C214