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The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population

Sponsor
Asfendiyarov Kazakh National Medical University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05088512
Collaborator
(none)
300
Enrollment
1
Location
25.9
Anticipated Duration (Months)
11.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.

Condition or Disease Intervention/Treatment Phase
  • Genetic: SNP analysis of the DNA

Detailed Description

Unrelated Kazaks subjects who have bronchial asthma were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with bronchial asthma and normal control subjects free of bronchial asthma

Study Design

Study Type:
Observational
Anticipated Enrollment :
300 participants
Observational Model:
Other
Time Perspective:
Prospective
Official Title:
Preventive and Personalized Medicine (2021-2023)
Anticipated Study Start Date :
Oct 23, 2021
Anticipated Primary Completion Date :
Dec 20, 2022
Anticipated Study Completion Date :
Dec 20, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental group:

Patients with bronchial asthma

Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Control group

Patients without bronchial asthma

Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Outcome Measures

Primary Outcome Measures

  1. number of SNPs associated with bronchial asthma [1 year]

    Using SNPsto identify candidate genes associate with bronchial asthma

Eligibility Criteria

Criteria

Ages Eligible for Study:
5 Years to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • Persons with bronchial asthma confirmed by a doctor;

  • The age of the patients is from 5 to 60 years;

  • Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.

  • Persons who are able and willing to provide written informed consent;

  • Persons capable and willing to comply with the research protocol;

Exclusion Criteria:

  • Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;

  • Pregnant or lactating women;

  • Tuberculosis of any localization in the active phase and in history;

  • Severe and decompensated diseases of the liver and kidneys, cardiovascular system;

  • Severe and decompensated course of endocrine diseases;

  • Autoimmune diseases;

  • Systemic diseases;

  • Oncological diseases;

Contacts and Locations

Locations

Site City State Country Postal Code
1 Kazakhstan Almaty Kazakhstan 050020

Sponsors and Collaborators

  • Asfendiyarov Kazakh National Medical University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Ildar Fakhradiyev, Project manager, Asfendiyarov Kazakh National Medical University
ClinicalTrials.gov Identifier:
NCT05088512
Other Study ID Numbers:
  • 1207
First Posted:
Oct 22, 2021
Last Update Posted:
Oct 22, 2021
Last Verified:
Oct 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Ildar Fakhradiyev, Project manager, Asfendiyarov Kazakh National Medical University
Bronchial Asthma
Genome Wide Association Studies
Additional relevant MeSH terms:
Asthma

Study Results

No Results Posted as of Oct 22, 2021