Role OF Geometric Mean in Estimation OF Differential Renal Function in DMSA Scintigraphy
Study Details
Study Description
Brief Summary
Renal scintigraphy is an imaging method that uses small amount of radioactive materials called radiotracers, a Gamma camera and a computer to evaluate kidney functions and its anatomy.
The relative renal function (RRF), expressed as a percent of total renal function, is important in the initial assessment and treatment of patients having renal diseases. RRF has traditionally been measured by radionuclide renal scintigraphies using different tracers for a long time . Different radiopharmaceuticals such as technetium-99m-diethylenetriaminepentaacetic acid (99mTc-DTPA), technetium-99m-dimercaptosuccinic acid (99mTc-DMSA), technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3).
99mTc-DMSA is a static agent that is actively taken up by the proximal and distal renal tubular cells, directly from the peritubular vessels and accumulates in the renal cortex. Its binding level to protein in mammals is 90% which prevents significant glomerular filtration. DMSA renal scan images provide a good definition of the cortical outline, as well as they show the relative distribution of functional tissue.
Determination of the left to right dimercaptosuccinic acid (DMSA) uptake ratio is theoretically one of the easiest quantitative procedures in nuclear medicine. The quantification can be performed on the posterior view, with or without the lateral view for correction of kidney depth. The geometric mean can also be determined using both the anterior and the posterior views.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- geometric mean of both anterior and posterior views of gamma camera [6 months]
. We evaluate the discrepancy between function measured by conjugate anterior and posterior views in relationship to posterior view in DMSA scan .
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients referred for renal DMSA scintigraphy
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Patients aging 2 to 70 years
Exclusion Criteria:
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Single kidney patients
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Patients with a major uncontrollable medical illness.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sohag University Hospital | Sohag | Egypt |
Sponsors and Collaborators
- Sohag University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Arteaga MV, Caballero VM, Rengifo KM. Dosimetry of (99m)Tc (DTPA, DMSA and MAG3) used in renal function studies of newborns and children. Appl Radiat Isot. 2018 Aug;138:25-28. doi: 10.1016/j.apradiso.2017.07.054. Epub 2017 Jul 28.
- Hervás I, Martí JF, González A, Ruiz JC, Alonso J, Bello P, Manzano F, Torres I, Mateo A. Is the depth correction using the geometric mean really necessary in a 99Tcm-DMSA scan in the paediatric population? Nucl Med Commun. 2001 May;22(5):547-52.
- Miyazaki C, Harada H, Shuke N, Okizaki A, Miura M, Hirano T. (99m)Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors. Ann Nucl Med. 2010 Apr;24(3):189-95. doi: 10.1007/s12149-010-0349-y. Epub 2010 Mar 9.
- Soh-Med-22-04-06