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Oxidative Stress Markers in COPD

Sponsor
Minia University (Other)
Overall Status
Completed
CT.gov ID
NCT04748887
Collaborator
(none)
70
Enrollment
1
Location
12
Actual Duration (Months)
5.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Condition or Disease Intervention/Treatment Phase
  • Other: oxidative stess markers

Study Design

Study Type:
Observational [Patient Registry]
Actual Enrollment :
70 participants
Observational Model:
Case-Control
Time Perspective:
Cross-Sectional
Official Title:
Chronic Obstructive Pulmonary Disease in Non Smokers:Role of Oxidative Stress
Actual Study Start Date :
Sep 1, 2018
Actual Primary Completion Date :
Apr 1, 2019
Actual Study Completion Date :
Sep 1, 2019

Arms and Interventions

Arm Intervention/Treatment
nonsmokers copd cases ,

Fourty subjects of COPD who are non-smokers or stopped smoking for more than 6 months

Other: oxidative stess markers
markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .
Other Names:
  • Superoxide Dismutase (SOD) and Malondialdehyde (MDA)

    		•
    non smokers healthy control

    Thirty subjects of non smokers healthy control

    Other: oxidative stess markers
    markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .
    Other Names:
  • Superoxide Dismutase (SOD) and Malondialdehyde (MDA)

    		•

    Outcome Measures

    Primary Outcome Measures

    1. oxidative stress markers in non smokers COPD compared to healthy control [1month]

      markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Inclusion Criteria:
    • 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control
    Exclusion Criteria:
    • Patients of:

    1. Acute exacerbation, at the time of the study, of COPD.

    2. Any obvious abnormal lung parenchymal lesions.

    3. Lung cancer.

    4. Congestive heart failure.

    5. current smokers

    6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Minia University Hospital Multiple Locations Minia Egypt 61691

    Sponsors and Collaborators

    • Minia University

    Investigators

    • Principal Investigator: zainab H Saeed, MD, MD chest diseases

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    zainab hassan saeed, principle investigator ,faculty of medicine,department of chest diseases,Minia University, Minia University
    ClinicalTrials.gov Identifier:
    NCT04748887
    Other Study ID Numbers:
    • oxidative stress
    First Posted:
    Feb 10, 2021
    Last Update Posted:
    Feb 10, 2021
    Last Verified:
    Feb 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by zainab hassan saeed, principle investigator ,faculty of medicine,department of chest diseases,Minia University, Minia University
    COPD , oxidative stress, Superoxide Dismutase
    Additional relevant MeSH terms:
    Superoxide Dismutase

    Study Results

    No Results Posted as of Feb 10, 2021