Role of Surgery in Treatment of Recurrent Brian Glioma:Prognostic Factors and Outcome
Study Details
Study Description
Brief Summary
role of surgery in treatment of recurrent brain glioma prognostic factors and outcome measures Role of surgery : In patients with Grade I gliomas, such as pilocytic astrocytomas, resection is potentially curative.
For more diffuse invasive gliomas (Grade II or higher), initial management typically includes maximal safe resection when possible.
Increasing evidence supports an association between extent of resection and prolonged progression-free and overall survival for patients with diffuse gliomas of all types and grades Many studies reported that more that 90%of patients with glioma showed recurrence at the orginal tumor location.
Review the outcomes of re-operation in treatment of recurrent brain gliomas To determine the prognostic factors which can predict which patient would benefit from multiple surgery .
Trail to Improve the outcome of these patients and decrease rate of complications
| Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Outcome Measures
Primary Outcome Measures
- karnofsky performance status [1year]
A standard way of measuring the ability of cancer patients to perform ordinary tasks. The Karnofsky Performance Status scores range from 0 to 100. A higher score means the patient is better able to carry out daily activities. Karnofsky Performance Status may be used to determine a patient's prognosis, to measure changes in a patient's ability to function, or to decide if a patient could be included in a clinical trial. Also called KPS.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patient previously operated and documented as a glioma with clinical and neuroimaging and pathological evidences.
Patients who will undergo re-operation for treatment of a recurrent brain glioma at the time of study(one year) Histological types : Different histological types of glioma.
Exclusion Criteria:
- patients has brain glioma that is de novo patients who are unfit for any neurosurgical interventions. Multicentric recurrent glioma.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Assuit University Hospitals | Assiut | Egypt |
Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: Ahmed AlGhriany, phD, professor of neurosurgery assiut university
- Study Director: Ahmed AlShanawany, phD, assistant professor of neurosurgery assiut university
- Principal Investigator: Mohamad S Waer, Resident at department of neurosurgery
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- surgery in glioma