Clincosm LogoSign in Get a demo

The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

Sponsor
Chinese University of Hong Kong (Other)
Overall Status
Terminated
CT.gov ID
NCT00164814
Collaborator
(none)
100
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease. Despite its benign nature, this condition causes anxiety, impairs quality of life and consumes a substantial amount of healthcare resources. While acid reflux and motility disorder in the esophagus are often attributed as the cause of NCCP, visceral hyperalgesia of esophagus is now recognized to play a central role in the pathogenesis of this condition. This research project aims to evaluate the role of visceral hyperalgesia in Chinese patients with NCCP. NCCP patients will be evaluated for the prevalence of gastroesophageal reflux disease and esophageal motility disorder by endoscopy, manometry and pH study. The visceral sensory and pain thresholds of these patients will be compared with asymptomatic controls.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    100 participants
    Time Perspective:
    Prospective
    Official Title:
    Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pian in Chinese? Part I: The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 70 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy

      • Age between 18-70

      Exclusion Criteria:

      • Gastroesophageal reflux disease

      • Psychiatric illness

      • Cerebrovascular accident

      • Active peptic ulceration

      • Heart failure or cardiac bradyarrhythmia

      • Epilepsy

      • Pregnancy or lactating female

      • Previous hypersensitivity to muscle relaxant

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Endoscopy Centre, Prince of Wales Hospital Hong Kong China

      Sponsors and Collaborators

      • Chinese University of Hong Kong

      Investigators

      • Principal Investigator: Justin CY WU, MD, Chinese University of Hong Kong

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00164814
      Other Study ID Numbers:
      • NPA study
      First Posted:
      Sep 14, 2005
      Last Update Posted:
      Mar 26, 2008
      Last Verified:
      Mar 1, 2008
      Additional relevant MeSH terms:
      Gastroesophageal Reflux
      Esophageal Motility Disorders
      Esophageal Spasm, Diffuse
      Hyperalgesia
      Chest Pain

      Study Results

      No Results Posted as of Mar 26, 2008