Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

Sponsor

Fayoum University (Other)

Overall Status

Completed

CT.gov ID

NCT04410679

Collaborator

(none)

Enrollment

Location

Arm

Actual Duration (Months)

0.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

Condition or Disease	Intervention/Treatment	Phase
Root Resorption	Biological: injectable PRF	N/A

Detailed Description

13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Study Design

Study Type:

Interventional

Actual Enrollment :

10 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation

Actual Study Start Date :

Jun 3, 2018

Actual Primary Completion Date :

Jun 6, 2019

Actual Study Completion Date :

May 2, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: injectabl PRF for treatment of internal root resorption	Biological: injectable PRF blood sample and centrifuged to obtain i-PRF

Arm

Intervention/Treatment

Experimental: injectabl PRF for treatment of internal root resorption

Biological: injectable PRF

blood sample and centrifuged to obtain i-PRF

Outcome Measures

Primary Outcome Measures

change in volumetric size of internal root resorption lesions [12 months]
Measuring volumetric dimensions of resorption lesion pre and postoperatively using CBCT

Secondary Outcome Measures

change in volumetric size of periapical lesions [12 months]
Measuring volumetric dimensions of periapical lesion pre and postoperatively using CBCT

Eligibility Criteria

Criteria

Ages Eligible for Study:

13 Years to 30 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

patients 13-30 years old
no sex predilection
medically free
Suffering from internal inflammatory root resorption in permanent anterior mature teeth
associated with or without periapical radiolucency
no or grade I tooth mobility, and a pocket depth <3 mm