Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea

Sponsor

Hovione Scientia Limited (Industry)

Overall Status

Completed

CT.gov ID

NCT03263273

Collaborator

(none)

270

Enrollment

Locations

Arms

Actual Duration (Months)

11.7

Patients Per Site

0.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, as assessed by the change in inflammatory lesion count from baseline over the 12-week treatment period in patients with moderate-to-severe papulopustular rosacea.

Condition or Disease	Intervention/Treatment	Phase
Rosacea Papulopustular Rosacea	Drug: 1% Topical Minocycline Gel Drug: 3% Topical Minocycline Gel Other: Topical Vehicle Gel	Phase 2

Study Design

Study Type:

Interventional

Actual Enrollment :

270 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

A Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled Study to Evaluate the Safety and Efficacy of 1% and 3% Topical MIinocycline Gel (HY01) in Patients With Papulopustular Rosacea

Actual Study Start Date :

Oct 30, 2017

Actual Primary Completion Date :

Mar 1, 2019

Actual Study Completion Date :

Jul 1, 2019

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: Topical Vehicle Gel Topical administration of vehicle gel. Regimen: Apply once daily, at bedtime to the face	Other: Topical Vehicle Gel Treating Papulopustular Rosacea while monitoring for safety and efficacy of the vehicle intervention Other Names: HY01 Topical Gel, 0%
Active Comparator: 1% Topical Minocycline Gel Topical administration of 1% Topical Minocycline Gel. Regimen: Apply once daily, at bedtime to the face	Drug: 1% Topical Minocycline Gel Treating Papulopustular Rosacea while monitoring for safety and efficacy of the active intervention Other Names: HY01 Topical Gel, 1%
Active Comparator: 3% Topical Minocycline Gel Topical administration of 3% Topical Minocycline Gel. Regimen: Apply once daily, at bedtime to the face	Drug: 3% Topical Minocycline Gel Treating Papulopustular Rosacea while monitoring for safety and efficacy of the active intervention Other Names: HY01 Topical Gel, 3%

Arm

Intervention/Treatment

Placebo Comparator: Topical Vehicle Gel

Topical administration of vehicle gel. Regimen: Apply once daily, at bedtime to the face

Other: Topical Vehicle Gel

Treating Papulopustular Rosacea while monitoring for safety and efficacy of the vehicle intervention

Other Names:

HY01 Topical Gel, 0%

Active Comparator: 1% Topical Minocycline Gel

Topical administration of 1% Topical Minocycline Gel. Regimen: Apply once daily, at bedtime to the face

Drug: 1% Topical Minocycline Gel

Treating Papulopustular Rosacea while monitoring for safety and efficacy of the active intervention

Other Names:

HY01 Topical Gel, 1%

Active Comparator: 3% Topical Minocycline Gel

Topical administration of 3% Topical Minocycline Gel. Regimen: Apply once daily, at bedtime to the face

Drug: 3% Topical Minocycline Gel

Treating Papulopustular Rosacea while monitoring for safety and efficacy of the active intervention

Other Names:

HY01 Topical Gel, 3%

Outcome Measures

Primary Outcome Measures

Change in Lesion Count [12 weeks]
Evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, as assessed by the change in inflammatory lesion count from baseline in patients with moderate-to-severe papulopustular rosacea

Secondary Outcome Measures

Investigator's Global Assessment (IGA) Score [12 weeks]
Evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, in improving the Investigator's Global Assessment (IGA) scores from baseline over the 12-week treatment period in patients with moderate-to-severe papulopustular rosacea as defined as either a 2 point improvement from baseline or an improvement to "clear" or "almost clear" on the IGA

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Subjects who had provided written informed consent to participate in the study.
Male or non-pregnant female aged ≥ 18 years with a clinical diagnosis of moderate to severe facial rosacea, defined as the presence of: i. At least twelve and not more than forty inflammatory facial lesions (i.e., papules/pustules), AND ii. Subjects with a grade 3 or 4 on the 5-point Investigators Global Assessment (IGA) scale, AND iii. Persistent facial erythema (scored as at least mild on Erythema Severity Scale), AND

Facial telangiectasia (scored as at least mild on Telangiectasia Severity Scale.

Subject willing to minimize external factors that might trigger rosacea flare-ups as recommended per protocol and patient instructional guide (e.g., spicy foods, thermally hot foods and drinks, hot environments, prolonged sun exposure, strong winds and alcoholic beverages).
Non-nursing, female subjects of child bearing potential, who are using an acceptable form of birth control: total abstinence, oral (birth control pills), intravaginal: (e.g. NuvaRing®), implantable (e.g. Norplant®), injectable (e.g. Depo-Provera®) or transdermal (e.g. Ortho Evra®) contraception; intrauterine device (IUD); double-barrier (diaphragm or condom with spermicidal gel or foam); for two months prior to study enrollment or a vasectomized partner. All female subjects of child bearing potential must have undergone an in-office urine pregnancy test, with a negative result, prior to being randomized to receive study drug. In addition, women of childbearing potential must have agreed to a have urine pregnancy test at Day 42 and at the end of the study (Day 84). Females not of childbearing potential due to menopause must have been postmenopausal for at least one year. Male subjects must be willing to not attempt to conceive a child during the participation in the study. Females utilizing oral contraception must be willing to utilize an appropriate secondary form of contraception during the study.
Subjects who use the same brand of soap, make-up, hair products, or shaving lotion/foam/cream/gel for a period of at least four weeks prior to the Baseline Visit and agree not to change these product brand/types during the study, with the exception of using the study approved cleanser and moisturizer with sunscreen provided by the sponsor.
Male subjects who are willing to shave, if applicable, at approximately the same time every day.
Subjects who are willing to refrain from sunbathing, using sun tanning booths/beds, or excessive exposure to the sun for the duration of the study.

Exclusion Criteria:

Presence of any skin condition on the face that would interfere with the diagnosis or assessment of rosacea as determined by the Investigator.
Excessive facial hair (e.g. beards, sideburns, moustaches, etc.) that would interfere with diagnosis or assessment of rosacea. Patients also must not grow excess facial hair during the study (i.e. they need to be free of excess facial hair for follow-up visits).
History of hypersensitivity or allergy to minocycline, any other tetracycline or any other component of the formulation, or known reactions to cleansers, including Ponds Cold Cream, and moisturizer with sunscreen.
Subjects using, or planning use of concomitant treatments within 30 days prior to Baseline visit (e.g., facial or chemical peels, dermal fillers, acne surgery, intralesional steroids, spironolactone, debridement, cryotherapy, dermabrasion, X-ray, IPL, laser therapy or UV therapy).
Use within 6 months prior to baseline of oral retinoids (e.g. isotretinoin, acitretin) or therapeutic vitamin A supplements of greater than 10,000 International Units/day (multivitamins are allowed).
Subjects using estrogens or progestin agents (e.g., Gynogen, Valergen, Depo-Testadiol, Depogen, birth control pills), for less than 2 months prior to the Baseline Visit. (Subjects using estrogens for 2 months or more are not excluded unless the subject expected to change dose, drug, or discontinue estrogen use during the study).
Use within 2 month prior to the Baseline Visit of 1) topical retinoids to the face, 2) systemic antibiotics known to have an impact on the severity of facial rosacea (e.g., containing tetracycline and its derivatives, erythromycin and its derivatives, sulfamethoxazole, or trimethoprim, metronidazole), or 3) systemic corticosteroids.
Use within 2 months prior to the Baseline Visit of 1) topical corticosteroids, 2) topical antibiotics or 3) topical medications for rosacea (e.g., metronidazole, azelaic acid, erythromycin, ivermectin, sulfur based topical products).
Subjects with rhinophyma, dense telangiectasia, or plaque-like facial edema, more than 5 nodules or sinus tracts.
Ocular rosacea (e.g., conjunctivitis, blepharitis, or keratitis) of sufficient severity to require topical or systemic antibiotics.
Subjects with underlying diseases or other dermatological conditions, such as; atopic dermatitis, perioral dermatitis, or seborrheic dermatitis, which required the use of interfering topical or systemic therapy or may have interfered with the rosacea diagnosis.
Subjects using an investigational drug or participating in an investigational study within 30 days of the Baseline Visit. Use of an investigational drug and/or participation in another investigational study prohibited during this study.
Subjects who currently abuse alcohol or drugs or who have a history of chronic alcohol or drug abuse with in the past year.
Medical history of immunodeficiency or other significant ongoing medical condition or disease as determined by the investigator.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Clinical Site - 15	Bryant	Arkansas	United States	72022
2	Clinical Site - 20	Rogers	Arkansas	United States	72758
3	Center for Dermatology Clinical Research, Inc.	Fremont	California	United States	94538
4	Clinical Site - 19	Santa Monica	California	United States	90404
5	Clinical Site - 5	Tampa	Florida	United States	33624
6	Clinical Site - 16	Boise	Idaho	United States	83704
7	Clinical Site - 22	Boston	Massachusetts	United States	02116
8	Clinical Site - 23	Watertown	Massachusetts	United States	02472
9	Clinical Site - 14	Clinton Township	Michigan	United States	48038
10	Clinical Site - 6	Fridley	Minnesota	United States	55432
11	Clinical Site - 12	Omaha	Nebraska	United States	68144
12	Clinical Site - 21	Berlin	New Jersey	United States	08009
13	Clinical Site - 13	New York	New York	United States	10022
14	Clinical Site - 2	New York	New York	United States	10155
15	Clinical Site - 4	High Point	North Carolina	United States	27262
16	Clinical Site - 17	Portland	Oregon	United States	97210
17	Clinical Site - 11	Fort Washington	Pennsylvania	United States	19034
18	Clinical Site - 8	Goodlettsville	Tennessee	United States	37072
19	Clinical Site - 7	Pflugerville	Texas	United States	78660
20	Clinical Site - 18	San Antonio	Texas	United States	78213
21	Clinical Site - 3	San Antonio	Texas	United States	78229
22	Clinical Site - 9	San Antonio	Texas	United States	78229
23	Clinical Site - 10	Norfolk	Virginia	United States	23502