Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects.

Sponsor

Vest Brain,Centro de Estudios Neurovestibulares (Other)

Overall Status

Completed

CT.gov ID

NCT03421847

Collaborator

Centro de Medicina Aeroespacial. (Other)

Enrollment

17.5

Actual Duration (Months)

Study Details

Study Description

Brief Summary

This study evaluates the vestibular activity in major depression patients and healthy controls using the rotatory test and electronystagmography.

Condition or Disease	Intervention/Treatment	Phase
Depression Vestibular Disorder	Diagnostic Test: Rotatory vestibular test

Detailed Description

Previous studies showed abnormal vestibular activity in major depression patients using caloric vestibular tests. The present study investigates the vestibular response to vestibular rotatory tests in major depression subjects and healthy controls.

Study Design

Study Type:

Observational

Actual Enrollment :

41 participants

Observational Model:

Case-Control

Time Perspective:

Other

Official Title:

Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects.

Actual Study Start Date :

Jul 1, 2005

Actual Primary Completion Date :

Dec 15, 2006

Actual Study Completion Date :

Dec 15, 2006

Arms and Interventions

Arm	Intervention/Treatment
Major Depression Group We will measure the vestibular activity of Major depression patients with Rotatory Test and electronystagmography	Diagnostic Test: Rotatory vestibular test We will measure Depression and Healthy subjects vestibular activity by Rotatory Vestibular tests
Healthy Control Group We will measure the vestibular activity of Healthy subjects with Rotatory Test and electronystagmography.	Diagnostic Test: Rotatory vestibular test We will measure Depression and Healthy subjects vestibular activity by Rotatory Vestibular tests

Arm

Intervention/Treatment

Major Depression Group

We will measure the vestibular activity of Major depression patients with Rotatory Test and electronystagmography

Diagnostic Test: Rotatory vestibular test

We will measure Depression and Healthy subjects vestibular activity by Rotatory Vestibular tests

Healthy Control Group

We will measure the vestibular activity of Healthy subjects with Rotatory Test and electronystagmography.

Diagnostic Test: Rotatory vestibular test

We will measure Depression and Healthy subjects vestibular activity by Rotatory Vestibular tests

Outcome Measures

Primary Outcome Measures

Vestibular Activity [Vestibular rotatory test for each participant is about 50- 60 minutes. One rotatory test per participant.]
The primary outcome corresponds to the vestibular activity. The vestibular stimulation provided by the rotatory chair is sensed by the inner ear´s vestibular receptors and generates reflex ocular movements(Vestibulo Ocular Reflex) registrated by electronystagmography. The main outcome corresponds to the asymmetry of the vestibular activity between both ears.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

male and females adults (18 years or older)
met the Diagnosing and Statistical Manual of Mental Disorders (DSM-IV-R, American Psychiatric Association, 2000) criterion.
had a score of 12 or more in the Hamilton Rating Scale, 21 items for Depression.
with or without actual pharmacological treatment, except benzodiazepines that were suspended 24 hours before the rotary test when corresponding.