Routine Transcervical Thymectomy in MEN-1 Patients
Study Details
Study Description
Brief Summary
A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Introduction and Importance Malignant thymic carcinoids are uncommon but important entities among patients with multiple endocrine neoplasia type 1 (MEN-1). Current treatment guidelines advise the performance of a routine transcervical thymectomy (TCT) during parathyroidectomy, to prevent its development, although data on the yield of this prophylactic TCT is scarce. We aimed to revisit available literature to investigate and summarize the efficacy of routine TCT during neck exploration for parathyroidectomy, for the prevention of thymic carcinoid tumours among MEN-1 patients.
Methods A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| MEN-1 patients who underwent routine thymectomy during parathyroidecotmy A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids. |
Procedure: Routine thymectomy, which has been performed
There is no intervention
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Outcome Measures
Primary Outcome Measures
- Incidence of thyme carcinoid [The timeframe will be from date of transcervical thymectomy until the date of documented diagnosis of diagnosis of thymic NET; progression of disease or date of death from any cause, whichever came first, assessed up to 100 months.]
Retrospective review of published studies
Eligibility Criteria
Criteria
Inclusion Criteria:
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Studies including MEN-1 patients who underwent a routine thymectomy during parathyoidectomy
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We accepted randomized controlled trials or observational studies that included patients of any age who underwent a routine TCT in the setting for MEN-1, published as full-length articles in peer-reviewed journals, which mentioned data on thymic carcinoid tumours.
Exclusion Criteria:
- We excluded reviews, letters, conference proceedings and non-English publications.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National University Hospital | Singapore | Singapore |
Sponsors and Collaborators
- National University Health System, Singapore
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- exempt from review