S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases

Sponsor
Southwest Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00874211
Collaborator
National Cancer Institute (NCI) (NIH), Novartis (Industry)
3,571
453
126
7.9
0.1

Study Details

Study Description

Brief Summary

RATIONALE: Gathering information about how often osteonecrosis of the jaw occurs in patients receiving zoledronic acid for bone metastases may help doctors learn more about the disease and provide the best follow-up care.

PURPOSE: This clinical trial is studying osteonecrosis of the jaw in patients with cancer who are receiving zoledronic acid for bone metastases.

Condition or Disease Intervention/Treatment Phase
  • Procedure: assessment of therapy complications

Detailed Description

OBJECTIVES:

Primary

  • To prospectively access the cumulative incidence of osteonecrosis of the jaw (ONJ) at 3 years in cancer patients with bone metastasis receiving zoledronic acid treatment.

Secondary

  • To describe the clinical presentation and natural history of ONJ.

  • To identify potential risk factors for the development of ONJ.

  • To estimate the cumulative incidence of ONJ at 3 years for different tumor types (i.e., breast cancer, multiple myeloma, prostate cancer, lung cancer, and other cancers).

  • To better define the patient-related outcomes of ONJ.

OUTLINE: This is a multicenter study.

Patients undergo dental assessments at baseline and every 3-6 months for 3 years.

Study Design

Study Type:
Observational
Actual Enrollment :
3571 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
S0702: A Prospective Observational Multicenter Cohort Study to Assess the Incidence of Osteonecrosis of the Jaw (ONJ) in Cancer Patients With Bone Metastases Starting Zoledronic Acid Treatment
Actual Study Start Date :
Dec 1, 2008
Actual Primary Completion Date :
Jun 1, 2019
Actual Study Completion Date :
Jun 1, 2019

Arms and Interventions

Arm Intervention/Treatment
Observation

Patients will be observed and will undergo assessment of therapy complications.

Procedure: assessment of therapy complications
By dental and medical assessments.

Outcome Measures

Primary Outcome Measures

  1. Diagnosis of confirmed osteonecrosis of the jaw (ONJ) [3 years]

Secondary Outcome Measures

  1. Disease-specific estimates of the confirmed cumulative incidence at 3 years of ONJ [3 years]

  2. Clinical presentation and natural history of ONJ [3 years]

  3. Overall and disease-specific cumulative incidence [3 years]

  4. Association of baseline factors with cumulative incidence of confirmed ONJ [3 years]

  5. Association between patient-related outcomes and confirmed incidence [3 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:
N/A to 120 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS:
  • Participant must have bone metastasis from multiple myeloma, solid tumors, or other malignancy for which intravenous bisphosphonate has clinical indications in the treatment of metastatic bone disease

  • Treatment with osteoclast inhibition is clinically indicated

  • Must be planning to receive zoledronic acid* within the next 30 days NOTE: *Osteoclast inhibition therapy will continue thereafter as clinically indicated.

  • No prior diagnosis of osteonecrosis of the jaw

  • Patients previously treated with osteoclast inhibition therapy are eligible, provided the following criteria apply:

  • Prior osteoclast inhibition for low bone mass (osteoporosis or osteopenia):

  • Patients may have previously received at most 3 doses of osteoclast-inhibiting therapy with denosumab, IV ibandronate, pamidronate, or zoledronic acid for low bone mass (osteopenia or osteoporosis) within 3 years prior to registration

  • Prior oral bisphosphonate therapy at osteoporosis or osteopenia dosing at any time prior to registration is allowed

  • Prior exposures to other medications used to treat low bone mass at osteoporosis or osteopenia dosing are permitted

  • Prior osteoclast inhibition for metastatic bone disease (tumor involving bone):

  • Patients may have previously received osteoclast-inhibiting therapy with denosumab, ibandronate (oral or IV cancer dosing), pamidronate, or zoledronic acid to treat metastatic bone disease within 180 days prior to registration

  • Patients receiving these regimens for metastatic bone disease prior to 180 days before registration are not eligible

  • Prior osteoclast-inhibiting therapy at higher dosing than outlined above at any time prior to registration is not allowed

PATIENT CHARACTERISTICS:
  • Zubrod performance status 0-3

  • Patients who may be acutely ill from spinal cord compromise, hypercalcemia of malignancy, or other process may be study candidates once the acute condition has been addressed and performance status improves to 0-3

  • Not pregnant or nursing

  • Negative pregnancy test

  • Willing and physically able to comply with study procedures and assessments

  • Willing to provide information on personal history, including tobacco and alcohol use, and pain assessment

  • Willing to provide access to prior and future dental information

  • No other prior malignancy except for any of the following:

  • Adequately treated basal cell carcinoma or squamous cell carcinoma of the skin

  • In situ cervical cancer

  • Adequately treated stage I or II cancer for which the patient is currently in complete remission

  • Any other cancer for which the patient has been disease-free for 5 years

PRIOR CONCURRENT THERAPY:
  • See Disease Characteristics

  • No history of radiation to the maxillofacial area administered for therapeutic intent in the treatment of cancer

  • Concurrent participation in other therapeutic and non-therapeutic clinical trials allowed

  • The sum of prior IV bisphosphonate doses must not be greater than 10

  • The sum of prior denosumab doses must not be greater than 8

  • The total of both IV bisphosphonate and denosumab used for any indication must not be greater than 12 doses

Contacts and Locations

Locations

Site City State Country Postal Code
1 Regional Medical Center Anniston Alabama United States 36207
2 Providence Cancer Center at Providence Hospital Mobile Alabama United States 36608
3 Providence Cancer Center Anchorage Alaska United States 99508
4 Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
5 NEA Medical Clinic - East Matthews Jonesboro Arkansas United States 72401
6 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
7 East Bay Radiation Oncology Center Castro Valley California United States 94546
8 Valley Medical Oncology Consultants - Castro Valley Castro Valley California United States 94546
9 Cancer Care Center at John Muir Health - Concord Campus Concord California United States 94524-4110
10 City of Hope Comprehensive Cancer Center Duarte California United States 91010-3000
11 North Bay Cancer Center Fairfield California United States 94533
12 Valley Medical Oncology Fremont California United States 94538
13 Sierra Nevada Cancer Center at Sierra Nevada Memorial Hospital Grass Valley California United States 95945
14 Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center Long Beach California United States 90806
15 USC/Norris Comprehensive Cancer Center and Hospital Los Angeles California United States 90089-9181
16 Contra Costa Regional Medical Center Martinez California United States 94553-3156
17 Tibotec Therapeutics - Division of Ortho Biotech Products, LP Marysville California United States 95901
18 Mercy Cancer Center at Mercy Medical Center Merced California United States 95340
19 El Camino Hospital Cancer Center Mountain View California United States 94040
20 Highland General Hospital Oakland California United States 94602
21 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
22 Bay Area Breast Surgeons, Incorporated Oakland California United States 94609
23 CCOP - Bay Area Tumor Institute Oakland California United States 94609
24 Larry G Strieff MD Medical Corporation Oakland California United States 94609
25 Tom K Lee, Incorporated Oakland California United States 94609
26 Epic Care - Oakland Oakland California United States 94612
27 St. Joseph Hospital Regional Cancer Center - Orange Orange California United States 92868
28 Valley Medical Oncology Consultants - Pleasanton Pleasanton California United States 94588
29 University of California Davis Cancer Center Sacramento California United States 95817
30 Doctors Medical Center - San Pablo Campus San Pablo California United States 94806
31 Tahoe Forest Cancer Center Truckee California United States 96161
32 John Muir/Mt. Diablo Comprehensive Cancer Center Walnut Creek California United States 94598
33 Aurora Presbyterian Hospital Aurora Colorado United States 80012
34 Boulder Community Hospital Boulder Colorado United States 80301-9019
35 Memorial Hospital Cancer Center - Colorado Springs Colorado Springs Colorado United States 80909
36 Penrose Cancer Center at Penrose Hospital Colorado Springs Colorado United States 80933
37 St. Anthony Central Hospital Denver Colorado United States 80204
38 Porter Adventist Hospital Denver Colorado United States 80210
39 Presbyterian - St. Luke's Medical Center Denver Colorado United States 80218
40 St. Joseph Hospital Denver Colorado United States 80218
41 Rose Medical Center Denver Colorado United States 80220
42 CCOP - Colorado Cancer Research Program Denver Colorado United States 80222
43 Swedish Medical Center Englewood Colorado United States 80110
44 Poudre Valley Hospital Fort Collins Colorado United States 80524
45 Front Range Cancer Specialists Fort Collins Colorado United States 80528
46 St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center Grand Junction Colorado United States 81502
47 North Colorado Medical Center Greeley Colorado United States 80631
48 Littleton Adventist Hospital Littleton Colorado United States 80122
49 Sky Ridge Medical Center Lone Tree Colorado United States 80124
50 Hope Cancer Care Center at Longmont United Hospital Longmont Colorado United States 80501
51 McKee Medical Center Loveland Colorado United States 80539
52 Parker Adventist Hospital Parker Colorado United States 80138
53 St. Mary - Corwin Regional Medical Center Pueblo Colorado United States 81004
54 North Suburban Medical Center Thornton Colorado United States 80229
55 Exempla Lutheran Medical Center Wheat Ridge Colorado United States 80033
56 Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Hartford Connecticut United States 06105
57 Tunnell Cancer Center at Beebe Medical Center Lewes Delaware United States 19958
58 CCOP - Christiana Care Health Services Newark Delaware United States 19713
59 Broward General Medical Center Cancer Center Fort Lauderdale Florida United States 33316
60 Sacred Heart Cancer Center at Sacred Heart Hospital Pensacola Florida United States 32504
61 Sacred Heart Medical Oncology Pensacola Florida United States 32514
62 H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Tampa Florida United States 33612-9497
63 Space Coast Medical Associates Titusville Florida United States 32796
64 Piedmont Hospital Atlanta Georgia United States 30309
65 Northside Hospital Cancer Center Atlanta Georgia United States 30342-1611
66 Saint Joseph's Hospital of Atlanta Atlanta Georgia United States 30342-1701
67 CCOP - Atlanta Regional Atlanta Georgia United States 30342
68 WellStar Cobb Hospital Austell Georgia United States 30106
69 John B. Amos Cancer Center Columbus Georgia United States 31904
70 Charles B. Eberhart Cancer Center at DeKalb Medical Center Decatur Georgia United States 30033
71 Piedmont Fayette Hospital Fayetteville Georgia United States 30214
72 Northeast Georgia Medical Center Gainesville Georgia United States 30501
73 Gwinnett Medical Center Lawrenceville Georgia United States 30045
74 Kennestone Cancer Center at Wellstar Kennestone Hospital Marietta Georgia United States 30060
75 Southern Regional Medical Center Riverdale Georgia United States 30274-2600
76 Harbin Clinic Cancer Center - Medical Oncology Rome Georgia United States 30165
77 Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center Savannah Georgia United States 31403-3089
78 Pearlman Comprehensive Cancer Center at South Georgia Medical Center Valdosta Georgia United States 31602
79 Kapiolani Medical Center at Pali Momi 'Aiea Hawaii United States 96701
80 Cancer Research Center of Hawaii Honolulu Hawaii United States 96813
81 OnCare Hawaii, Incorporated - Lusitana Honolulu Hawaii United States 96813
82 Queen's Cancer Institute at Queen's Medical Center Honolulu Hawaii United States 96813
83 Straub Clinic and Hospital, Incorporated Honolulu Hawaii United States 96813
84 Hawaii Medical Center - East Honolulu Hawaii United States 96817
85 OnCare Hawaii, Incorporated - Kuakini Honolulu Hawaii United States 96817
86 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
87 Tripler Army Medical Center Honolulu Hawaii United States 96859
88 Kauai Medical Clinic Lihue Hawaii United States 96766
89 Maui Memorial Medical Center Wailuku Hawaii United States 96793
90 Pacific Cancer Institute - Maui Wailuku Hawaii United States 96793
91 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Boise Idaho United States 83706
92 Mountain States Tumor Institute at St. Luke's Regional Medical Center Boise Idaho United States 83712
93 Saint Luke's Mountain States Tumor Institute - Fruitland Fruitland Idaho United States 83619
94 St. Joseph Regional Medical Center Lewiston Idaho United States 83501
95 Mountain States Tumor Institute - Meridian Meridian Idaho United States 83642
96 Saint Luke's Mountain States Tumor Institute Nampa Idaho United States 83686
97 Mountain States Tumor Institute at St. Luke's Twin Falls Idaho United States 83301
98 Rush-Copley Cancer Care Center Aurora Illinois United States 60504
99 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
100 John H. Stroger, Jr. Hospital of Cook County Chicago Illinois United States 60612-3785
101 Louis A. Weiss Memorial Hospital Chicago Illinois United States 60640
102 Decatur Memorial Hospital Cancer Care Institute Decatur Illinois United States 62526
103 Sherman Hospital Elgin Illinois United States 60123
104 Evanston Hospital Evanston Illinois United States 60201-1781
105 Delnor Hospital - Geneva Geneva Illinois United States 60134
106 Veterans Affairs Medical Center - Hines Hines Illinois United States 60141
107 Cardinal Bernardin Cancer Center at Loyola University Medical Center Maywood Illinois United States 60153
108 Trinity Cancer Center at Trinity Medical Center - 7th Street Campus Moline Illinois United States 61265
109 Moline Illinois United States 61265
110 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
111 West Suburban Center for Cancer Care River Forest Illinois United States 60305
112 Regional Cancer Center at Memorial Medical Center Springfield Illinois United States 62781-0001
113 CCOP - Carle Cancer Center Urbana Illinois United States 61801
114 Central Dupage Cancer Center Warrenville Illinois United States 60555
115 St. Francis Hospital and Health Centers - Beech Grove Campus Beech Grove Indiana United States 46107
116 Elkhart Clinic, LLC Elkhart Indiana United States 46514-2098
117 Michiana Hematology-Oncology, PC - Elkhart Elkhart Indiana United States 46514
118 Elkhart General Hospital Elkhart Indiana United States 46515
119 Howard Community Hospital Kokomo Indiana United States 46904
120 Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte Indiana United States 46350
121 Saint Anthony Memorial Health Centers Michigan City Indiana United States 46360
122 Michiana Hematology-Oncology, PC - South Bend Mishawaka Indiana United States 46545-1470
123 Saint Joseph Regional Medical Center Mishawaka Indiana United States 46545-1470
124 Michiana Hematology Oncology PC - Plymouth Plymouth Indiana United States 46563
125 Reid Hospital & Health Care Services Richmond Indiana United States 47374
126 CCOP - Northern Indiana CR Consortium South Bend Indiana United States 46601
127 Memorial Hospital of South Bend South Bend Indiana United States 46601
128 Michiana Hematology Oncology PC - La Porte Westville Indiana United States 46391
129 McFarland Clinic, PC Ames Iowa United States 50010
130 Bettendorf Iowa United States 52722
131 Cedar Rapids Oncology Associates Cedar Rapids Iowa United States 52403
132 Mercy Regional Cancer Center at Mercy Medical Center Cedar Rapids Iowa United States 52403
133 Medical Oncology and Hematology Associates - West Des Moines Clive Iowa United States 50325
134 Genesis Regional Cancer Center at Genesis Medical Center Davenport Iowa United States 52803
135 CCOP - Iowa Oncology Research Association Des Moines Iowa United States 50309
136 John Stoddard Cancer Center at Iowa Methodist Medical Center Des Moines Iowa United States 50309
137 Medical Oncology and Hematology Associates at John Stoddard Cancer Center Des Moines Iowa United States 50309
138 Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines Iowa United States 50314
139 Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
140 John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines Iowa United States 50316
141 Mercy Cancer Center at Mercy Medical Center - North Iowa Mason City Iowa United States 50401
142 Siouxland Hematology-Oncology Associates, LLP Sioux City Iowa United States 51101
143 Mercy Medical Center - Sioux City Sioux City Iowa United States 51102
144 St. Luke's Regional Medical Center Sioux City Iowa United States 51104
145 Cancer Center of Kansas, PA - Chanute Chanute Kansas United States 66720
146 Cancer Center of Kansas, PA - Dodge City Dodge City Kansas United States 67801
147 Cancer Center of Kansas, PA - El Dorado El Dorado Kansas United States 67042
148 Cancer Center of Kansas - Fort Scott Fort Scott Kansas United States 66701
149 Cancer Center of Kansas-Independence Independence Kansas United States 67301
150 Cancer Center of Kansas, PA - Kingman Kingman Kansas United States 67068
151 Lawrence Memorial Hospital Lawrence Kansas United States 66044
152 Cancer Center of Kansas, PA - Liberal Liberal Kansas United States 67901
153 Cancer Center of Kansas, PA - McPherson McPherson Kansas United States 67460
154 Cancer Center of Kansas, PA - Newton Newton Kansas United States 67114
155 Menorah Medical Center Overland Park Kansas United States 66209
156 Saint Luke's Hospital - South Overland Park Kansas United States 66213
157 Cancer Center of Kansas, PA - Parsons Parsons Kansas United States 67357
158 CCOP - Kansas City Prairie Village Kansas United States 66208
159 Cancer Center of Kansas, PA - Pratt Pratt Kansas United States 67124
160 Cancer Center of Kansas, PA - Salina Salina Kansas United States 67401
161 Tammy Walker Cancer Center at Salina Regional Health Center Salina Kansas United States 67401
162 Cotton-O'Neil Cancer Center Topeka Kansas United States 66606
163 Cancer Center of Kansas, PA - Wellington Wellington Kansas United States 67152
164 Associates in Womens Health, PA - North Review Wichita Kansas United States 67208
165 Cancer Center of Kansas, PA - Medical Arts Tower Wichita Kansas United States 67208
166 Cancer Center of Kansas, PA - Wichita Wichita Kansas United States 67214
167 CCOP - Wichita Wichita Kansas United States 67214
168 Via Christi Cancer Center at Via Christi Regional Medical Center Wichita Kansas United States 67214
169 Cancer Center of Kansas, PA - Winfield Winfield Kansas United States 67156
170 Ochsner Health Center - Bluebonnet Baton Rouge Louisiana United States 70809
171 Ochsner Health Center - Covington Covington Louisiana United States 70433
172 Louisiana State University Health Sciences Center - Monroe Monroe Louisiana United States 71210
173 CCOP - Ochsner New Orleans Louisiana United States 70121
174 Ochsner Cancer Institute at Ochsner Clinic Foundation New Orleans Louisiana United States 70121
175 Highland Clinic Shreveport Louisiana United States 71105
176 Feist-Weiller Cancer Center at Louisiana State University Health Sciences Shreveport Louisiana United States 71130-3932
177 Union Hospital of Cecil County Elkton Maryland United States 21921
178 Caritas Holy Family Hospital Methuen Massachusetts United States 01844
179 Hickman Cancer Center at Bixby Medical Center Adrian Michigan United States 49221
180 Saint Joseph Mercy Cancer Center Ann Arbor Michigan United States 48106-0995
181 CCOP - Michigan Cancer Research Consortium Ann Arbor Michigan United States 48106
182 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109-0942
183 Battle Creek Health System Cancer Care Center Battle Creek Michigan United States 49017
184 Bay Regional Medical Center Bay City Michigan United States 48708
185 Mecosta County Medical Center Big Rapids Michigan United States 49307
186 Oakwood Cancer Center at Oakwood Hospital and Medical Center Dearborn Michigan United States 48123-2500
187 Josephine Ford Cancer Center at Henry Ford Hospital Detroit Michigan United States 48202
188 Green Bay Oncology, Limited - Escanaba Escanaba Michigan United States 49431
189 Genesys Hurley Cancer Institute Flint Michigan United States 48503
190 Hurley Medical Center Flint Michigan United States 48503
191 McLaren Cancer Institute Flint Michigan United States 48532
192 Singh and Arora Hematology Oncology, PC Flint Michigan United States 48532
193 Butterworth Hospital at Spectrum Health Grand Rapids Michigan United States 49503
194 CCOP - Grand Rapids Grand Rapids Michigan United States 49503
195 Lacks Cancer Center at Saint Mary's Health Care Grand Rapids Michigan United States 49503
196 Van Elslander Cancer Center at St. John Hospital and Medical Center Grosse Pointe Woods Michigan United States 48236
197 Dickinson County Healthcare System Iron Mountain Michigan United States 49801
198 Foote Memorial Hospital Jackson Michigan United States 49201
199 Borgess Medical Center Kalamazoo Michigan United States 49001
200 West Michigan Cancer Center Kalamazoo Michigan United States 49007-3731
201 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
202 Breslin Cancer Center at Ingham Regional Medical Center Lansing Michigan United States 48910
203 Sparrow Regional Cancer Center Lansing Michigan United States 48912-1811
204 Great Lakes Cancer Institute - Lapeer Campus Lapeer Michigan United States 48446
205 St. Mary Mercy Hospital Livonia Michigan United States 48154
206 Community Cancer Center of Monroe Monroe Michigan United States 48162
207 Mercy Memorial Hospital - Monroe Monroe Michigan United States 48162
208 Clemens Regional Medical Center Mount Clemens Michigan United States 48043
209 Mercy General Health Partners Muskegon Michigan United States 49444
210 Northern Michigan Hospital Petoskey Michigan United States 49770
211 St. Joseph Mercy Oakland Pontiac Michigan United States 48341-2985
212 Mercy Regional Cancer Center at Mercy Hospital Port Huron Michigan United States 48060
213 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
214 William Beaumont Hospital - Royal Oak Campus Royal Oak Michigan United States 48073
215 Seton Cancer Institute at Saint Mary's - Saginaw Saginaw Michigan United States 48601
216 Lakeland Regional Cancer Care Center - St. Joseph Saint Joseph Michigan United States 49085
217 Lakeside Cancer Specialists, PLLC Saint Joseph Michigan United States 49085
218 Providence Cancer Institute at Providence Hospital - Southfield Campus Southfield Michigan United States 48075
219 Munson Medical Center Traverse City Michigan United States 49684
220 St. John Macomb Hospital Warren Michigan United States 48093
221 St. Joseph's Medical Center Brainerd Minnesota United States 56401
222 Fairview Ridges Hospital Burnsville Minnesota United States 55337
223 Mercy and Unity Cancer Center at Mercy Hospital Coon Rapids Minnesota United States 55433
224 Duluth Clinic Cancer Center - Duluth Duluth Minnesota United States 55805-1983
225 CCOP - Duluth Duluth Minnesota United States 55805
226 Miller - Dwan Medical Center Duluth Minnesota United States 55805
227 Fairview Southdale Hospital Edina Minnesota United States 55435
228 Mercy and Unity Cancer Center at Unity Hospital Fridley Minnesota United States 55432
229 Hutchinson Area Health Care Hutchinson Minnesota United States 55350
230 HealthEast Cancer Care at St. John's Hospital Maplewood Minnesota United States 55109
231 Minnesota Oncology - Maplewood Maplewood Minnesota United States 55109
232 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital Minneapolis Minnesota United States 55407
233 Hennepin County Medical Center - Minneapolis Minneapolis Minnesota United States 55415
234 New Ulm Medical Center New Ulm Minnesota United States 56073
235 Humphrey Cancer Center at North Memorial Outpatient Center Robbinsdale Minnesota United States 55422-2900
236 CCOP - Metro-Minnesota Saint Louis Park Minnesota United States 55416
237 Park Nicollet Cancer Center Saint Louis Park Minnesota United States 55416
238 Regions Hospital Cancer Care Center Saint Paul Minnesota United States 55101
239 United Hospital Saint Paul Minnesota United States 55102
240 St. Francis Cancer Center at St. Francis Medical Center Shakopee Minnesota United States 55379
241 Lakeview Hospital Stillwater Minnesota United States 55082
242 Ridgeview Medical Center Waconia Minnesota United States 55387
243 Willmar Cancer Center at Rice Memorial Hospital Willmar Minnesota United States 56201
244 Minnesota Oncology - Woodbury Woodbury Minnesota United States 55125
245 University of Mississippi Cancer Clinic Jackson Mississippi United States 39216
246 Veterans Affairs Medical Center - Jackson Jackson Mississippi United States 39216
247 Regional Cancer Center at Singing River Hospital Pascagoula Mississippi United States 39581
248 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
249 Southeast Cancer Center Cape Girardeau Missouri United States 63703
250 Goldschmidt Cancer Center Jefferson City Missouri United States 65109
251 Saint Luke's Cancer Institute at Saint Luke's Hospital Kansas City Missouri United States 64111
252 North Kansas City Hospital Kansas City Missouri United States 64116
253 Heartland Hematology Oncology Associates, Incorporated Kansas City Missouri United States 64118
254 Veterans Affairs Medical Center - Kansas City Kansas City Missouri United States 64128
255 Research Medical Center Kansas City Missouri United States 64132
256 Saint Luke's East - Lee's Summit Lee's Summit Missouri United States 64086
257 Parvin Radiation Oncology Liberty Missouri United States 64068
258 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
259 Saint Joseph Oncology, Incorporated Saint Joseph Missouri United States 64507
260 Midwest Hematology Oncology Group, Incorporated Saint Louis Missouri United States 63109
261 Saint Louis University Cancer Center Saint Louis Missouri United States 63110
262 Missouri Baptist Cancer Center Saint Louis Missouri United States 63131
263 Christian Hospital Northeast Cancer Care Center Saint Louis Missouri United States 63136
264 CCOP - St. Louis-Cape Girardeau Saint Louis Missouri United States 63141
265 David C. Pratt Cancer Center at St. John's Mercy Saint Louis Missouri United States 63141
266 CCOP - Montana Cancer Consortium Billings Montana United States 59101
267 St. Vincent Healthcare Cancer Care Services Billings Montana United States 59101
268 Hematology-Oncology Centers of the Northern Rockies - Billings Billings Montana United States 59102
269 Billings Clinic - Downtown Billings Montana United States 59107-7000
270 Bozeman Deaconess Cancer Center Bozeman Montana United States 59715
271 St. James Healthcare Cancer Care Butte Montana United States 59701
272 Big Sky Oncology Great Falls Montana United States 59405-5309
273 Sletten Cancer Institute at Benefis Healthcare Great Falls Montana United States 59405
274 St. Peter's Hospital Helena Montana United States 59601
275 Kalispell Medical Oncology at KRMC Kalispell Montana United States 59901
276 Kalispell Regional Medical Center Kalispell Montana United States 59901
277 Montana Cancer Specialists at Montana Cancer Center Missoula Montana United States 59807-7877
278 Montana Cancer Center at St. Patrick Hospital and Health Sciences Center Missoula Montana United States 59807
279 Good Samaritan Cancer Center at Good Samaritan Hospital Kearney Nebraska United States 68848-1990
280 Cancer Resource Center - Lincoln Lincoln Nebraska United States 68510
281 CCOP - Missouri Valley Cancer Consortium Omaha Nebraska United States 68106
282 Immanuel Medical Center Omaha Nebraska United States 68122
283 Alegant Health Cancer Center at Bergan Mercy Medical Center Omaha Nebraska United States 68124
284 Lakeside Hospital Omaha Nebraska United States 68130
285 Creighton University Medical Center Omaha Nebraska United States 68131-2197
286 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
287 CCOP - Nevada Cancer Research Foundation Las Vegas Nevada United States 89106
288 Nevada Cancer Institute Las Vegas Nevada United States 89135
289 UMDNJ University Hospital Newark New Jersey United States 07103
290 Cancer Institute of New Jersey at Cooper - Voorhees Voorhees New Jersey United States 08043
291 Hematology Oncology Associates, PC Albuquerque New Mexico United States 87106
292 University of New Mexico Cancer Center Albuquerque New Mexico United States 87131-5636
293 CCOP - Hematology-Oncology Associates of Central New York East Syracuse New York United States 13057
294 Falck Cancer Center at Arnot Ogden Medical Center Elmira New York United States 14905
295 James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester New York United States 14642
296 Mission Hospitals - Memorial Campus Asheville North Carolina United States 28801
297 Presbyterian Cancer Center at Presbyterian Hospital Charlotte North Carolina United States 28233-3549
298 Wayne Memorial Hospital, Incorporated Goldsboro North Carolina United States 27534
299 Pardee Memorial Hospital Hendersonville North Carolina United States 28791
300 FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center Pinehurst North Carolina United States 28374
301 Rutherford Hospital Rutherfordton North Carolina United States 28139
302 Iredell Memorial Hospital Statesville North Carolina United States 28677
303 Forsyth Regional Cancer Center at Forsyth Medical Center Winston-Salem North Carolina United States 27103
304 McDowell Cancer Center at Akron General Medical Center Akron Ohio United States 44307
305 Wood County Oncology Center Bowling Green Ohio United States 43402
306 Adena Regional Medical Center Chillicothe Ohio United States 45601
307 Charles M. Barrett Cancer Center at University Hospital Cincinnati Ohio United States 45267
308 Riverside Methodist Hospital Cancer Care Columbus Ohio United States 43214-3998
309 CCOP - Columbus Columbus Ohio United States 43215
310 Grant Medical Center Cancer Care Columbus Ohio United States 43215
311 Mount Carmel Health - West Hospital Columbus Ohio United States 43222
312 Doctors Hospital at Ohio Health Columbus Ohio United States 43228
313 Grandview Hospital Dayton Ohio United States 45405
314 Good Samaritan Hospital Dayton Ohio United States 45406
315 David L. Rike Cancer Center at Miami Valley Hospital Dayton Ohio United States 45409
316 Samaritan North Cancer Care Center Dayton Ohio United States 45415
317 CCOP - Dayton Dayton Ohio United States 45420
318 Grady Memorial Hospital Delaware Ohio United States 43015
319 Community Cancer Center Elyria Ohio United States 44035
320 Hematology Oncology Center Elyria Ohio United States 44035
321 Blanchard Valley Medical Associates Findlay Ohio United States 45840
322 Middletown Regional Hospital Franklin Ohio United States 45005-1066
323 Wayne Hospital Greenville Ohio United States 45331
324 Charles F. Kettering Memorial Hospital Kettering Ohio United States 45429
325 Fairfield Medical Center Lancaster Ohio United States 43130
326 Lima Memorial Hospital Lima Ohio United States 45804
327 Strecker Cancer Center at Marietta Memorial Hospital Marietta Ohio United States 45750
328 Northwest Ohio Oncology Center Maumee Ohio United States 43537-1839
329 Knox Community Hospital Mount Vernon Ohio United States 43050
330 Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark Ohio United States 43055
331 St. Charles Mercy Hospital Oregon Ohio United States 43616
332 Toledo Clinic - Oregon Oregon Ohio United States 43616
333 Southern Ohio Medical Center Cancer Center Portsmouth Ohio United States 45662
334 Community Hospital of Springfield and Clark County Springfield Ohio United States 45505
335 Flower Hospital Cancer Center Sylvania Ohio United States 43560
336 Mercy Hospital of Tiffin Tiffin Ohio United States 44883
337 Toledo Hospital Toledo Ohio United States 43606
338 St. Vincent Mercy Medical Center Toledo Ohio United States 43608
339 Medical University of Ohio Cancer Center Toledo Ohio United States 43614
340 CCOP - Toledo Community Hospital Toledo Ohio United States 43617
341 St. Anne Mercy Hospital Toledo Ohio United States 43623
342 Toledo Clinic, Incorporated - Main Clinic Toledo Ohio United States 43623
343 UVMC Cancer Care Center at Upper Valley Medical Center Troy Ohio United States 45373-1300
344 Fulton County Health Center Wauseon Ohio United States 43567
345 Mount Carmel St. Ann's Cancer Center Westerville Ohio United States 43081
346 United States Air Force Medical Center - Wright-Patterson Wright-Patterson Air Force Base Ohio United States 45433-5529
347 Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia Ohio United States 45385
348 Genesis - Good Samaritan Hospital Zanesville Ohio United States 43701
349 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
350 Bay Area Hospital Coos Bay Oregon United States 97420
351 Three Rivers Community Hospital Grants Pass Oregon United States 97527
352 Legacy Mount Hood Medical Center Gresham Oregon United States 97030
353 Dubs Cancer Center at Rogue Valley Medical Center Medford Oregon United States 97504
354 Providence Cancer Center at PMCC Medford Oregon United States 97504
355 Providence Milwaukie Hospital Milwaukie Oregon United States 97222
356 Providence Newberg Medical Center Newberg Oregon United States 97132
357 Willamette Falls Hospital Oregon City Oregon United States 97045
358 Legacy Good Samaritan Hospital & Comprehensive Cancer Center Portland Oregon United States 97210
359 Providence Cancer Center at Providence Portland Medical Center Portland Oregon United States 97213-2967
360 CCOP - Columbia River Oncology Program Portland Oregon United States 97225
361 Providence St. Vincent Medical Center Portland Oregon United States 97225
362 Legacy Meridian Park Hospital Tualatin Oregon United States 97062
363 Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest Allentown Pennsylvania United States 18105
364 Albert Einstein Cancer Center Philadelphia Pennsylvania United States 19141
365 AnMed Cancer Center Anderson South Carolina United States 29621
366 Hollings Cancer Center at Medical University of South Carolina Charleston South Carolina United States 29425
367 Cancer Centers of the Carolinas - Easley Easley South Carolina United States 29640
368 Bon Secours St. Francis Health System Greenville South Carolina United States 29601
369 Cancer Centers of the Carolinas - Faris Road Greenville South Carolina United States 29605
370 Cancer Centers of the Carolinas - Grove Commons Greenville South Carolina United States 29605
371 Greenville Hospital Cancer Center Greenville South Carolina United States 29605
372 Cancer Centers of the Carolinas - Eastside Greenville South Carolina United States 29615
373 CCOP - Greenville Greenville South Carolina United States 29615
374 Self Regional Cancer Center at Self Regional Medical Center Greenwood South Carolina United States 29646
375 Cancer Centers of the Carolinas - Greer Medical Oncology Greer South Carolina United States 29650
376 Cancer Centers of the Carolinas - Greer Radiation Oncology Greer South Carolina United States 29650
377 Cancer Centers of the Carolinas - Seneca Seneca South Carolina United States 29672
378 CCOP - Upstate Carolina Spartanburg South Carolina United States 29303
379 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg South Carolina United States 29303
380 Cancer Centers of the Carolinas - Spartanburg Spartanburg South Carolina United States 29307
381 Sanford Cancer Center at Sanford USD Medical Center Sioux Falls South Dakota United States 57117-5039
382 Cookeville Regional Medical Center Cookeville Tennessee United States 38501
383 Harrington Cancer Center Amarillo Texas United States 79106
384 Brooke Army Medical Center Fort Sam Houston Texas United States 78234-6200
385 University of Texas Medical Branch Galveston Texas United States 77555-0361
386 M. D. Anderson Cancer Center at University of Texas Houston Texas United States 77030-4009
387 Baylor University Medical Center - Houston Houston Texas United States 77030
388 Ben Taub General Hospital Houston Texas United States 77030
389 St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital Houston Texas United States 77030
390 Veterans Affairs Medical Center - Houston Houston Texas United States 77030
391 Veterans Affairs Medical Center - San Antonio (Murphy) San Antonio Texas United States 78209
392 University of Texas Health Science Center at San Antonio San Antonio Texas United States 78229-3900
393 Cancer Therapy and Research Center San Antonio Texas United States 78229
394 University Hospital - San Antonio San Antonio Texas United States 78229
395 CCOP - Scott and White Hospital Temple Texas United States 76508
396 American Fork Hospital American Fork Utah United States 84003
397 Sandra L. Maxwell Cancer Center Cedar City Utah United States 84720
398 Logan Regional Hospital Logan Utah United States 84321
399 Jon and Karen Huntsman Cancer Center at Intermountain Medical Center Murray Utah United States 84157
400 Val and Ann Browning Cancer Center at McKay-Dee Hospital Center Ogden Utah United States 84403
401 Utah Valley Regional Medical Center - Provo Provo Utah United States 84604
402 Dixie Regional Medical Center - East Campus Saint George Utah United States 84770
403 Utah Cancer Specialists at UCS Cancer Center Salt Lake City Utah United States 84106
404 Huntsman Cancer Institute at University of Utah Salt Lake City Utah United States 84112
405 LDS Hospital Salt Lake City Utah United States 84143
406 Fredericksburg Oncology, Incorporated Fredericksburg Virginia United States 22401
407 Island Hospital Cancer Care Center at Island Hospital Anacortes Washington United States 98221
408 St. Joseph Cancer Center Bellingham Washington United States 98225
409 Olympic Hematology and Oncology Bremerton Washington United States 98310
410 Highline Medical Center Cancer Center Burien Washington United States 98166
411 Providence Centralia Hospital Centralia Washington United States 98531-9027
412 Providence Regional Cancer Partnership Everett Washington United States 98201
413 St. Francis Hospital Federal Way Washington United States 98003
414 Swedish Medical Center - Issaquah Campus Issaquah Washington United States 98029
415 Columbia Basin Hematology Kennewick Washington United States 99336
416 Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland Washington United States 98033
417 Skagit Valley Hospital Cancer Care Center Mount Vernon Washington United States 98274
418 Providence St. Peter Hospital Regional Cancer Center Olympia Washington United States 98506-5166
419 Harrison Poulsbo Hematology and Onocology Poulsbo Washington United States 98370
420 Good Samaritan Cancer Center Puyallup Washington United States 98372
421 CCOP - Virginia Mason Research Center Seattle Washington United States 98101
422 Virginia Mason Medical Center Seattle Washington United States 98101
423 Harborview Medical Center Seattle Washington United States 98104
424 Minor and James Medical, PLLC Seattle Washington United States 98104
425 Pacific Medical Center Seattle Washington United States 98104
426 Fred Hutchinson Cancer Research Center Seattle Washington United States 98109
427 Group Health Central Hospital Seattle Washington United States 98112
428 Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle Washington United States 98122-4307
429 Polyclinic First Hill Seattle Washington United States 98122
430 University Cancer Center at University of Washington Medical Center Seattle Washington United States 98195
431 North Puget Oncology at United General Hospital Sedro-Woolley Washington United States 98284
432 Cancer Care Northwest - Spokane South Spokane Washington United States 99202
433 Evergreen Hematology and Oncology, PS Spokane Washington United States 99218
434 Franciscan Cancer Center at St. Joseph Medical Center Tacoma Washington United States 98405-3004
435 Allenmore Hospital Tacoma Washington United States 98405
436 CCOP - Northwest Tacoma Washington United States 98405
437 MultiCare Regional Cancer Center at Tacoma General Hospital Tacoma Washington United States 98405
438 St. Clare Hospital Tacoma Washington United States 98499
439 Southwest Washington Medical Center Cancer Center Vancouver Washington United States 98664
440 Legacy Salmon Creek Medical Center Vancouver Washington United States 98686
441 Wenatchee Valley Medical Center Wenatchee Washington United States 98801-2028
442 Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center Green Bay Wisconsin United States 54301-3526
443 Green Bay Oncology, Limited at St. Mary's Hospital Green Bay Wisconsin United States 54303
444 St. Mary's Hospital Medical Center - Green Bay Green Bay Wisconsin United States 54303
445 St. Vincent Hospital Regional Cancer Center Green Bay Wisconsin United States 54307-3508
446 Gundersen Lutheran Center for Cancer and Blood La Crosse Wisconsin United States 54601
447 Holy Family Memorial Medical Center Cancer Care Center Manitowoc Wisconsin United States 54221-1450
448 Green Bay Oncology, Limited - Oconto Falls Oconto Falls Wisconsin United States 54154
449 St. Nicholas Hospital Sheboygan Wisconsin United States 53081
450 Green Bay Oncology, Limited - Sturgeon Bay Sturgeon Bay Wisconsin United States 54235
451 Rocky Mountain Oncology Casper Wyoming United States 82609
452 Instituto Nacional de Cancerologia Tlalpan Mexico 14080
453 King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia 11211

Sponsors and Collaborators

  • Southwest Oncology Group
  • National Cancer Institute (NCI)
  • Novartis

Investigators

  • Study Chair: Catherine Van Poznak, MD, University of Michigan Rogel Cancer Center
  • Study Chair: Julie R. Gralow, MD, Seattle Cancer Care Alliance

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Southwest Oncology Group
ClinicalTrials.gov Identifier:
NCT00874211
Other Study ID Numbers:
  • S0702
  • S0702
  • U10CA037429
First Posted:
Apr 2, 2009
Last Update Posted:
Jul 5, 2019
Last Verified:
Jul 1, 2019

Study Results

No Results Posted as of Jul 5, 2019