Chemotherapy in Treating Children With Recurrent or Refractory Sarcomas
Study Details
Study Description
Brief Summary
Phase II trial to study the effectiveness of topotecan in treating children who have recurrent, relapsed, or refractory sarcoma. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 2 |
Detailed Description
OBJECTIVES:
- Determine the response rate in children with recurrent or refractory brain tumors, sarcomas, or neuroblastomas treated with topotecan. (Brain tumor and neuroblastoma strata closed to accrual effective 07/02/2001) II. Assess the toxicity of this regimen in a larger group of patients treated at the currently defined maximum tolerated dose.
OUTLINE: This is a multicenter study.
Patients receive topotecan IV continuously on days 1-21. Treatment continues at least every 4 weeks in the absence of unacceptable toxicity or disease progression.
Patients are followed every 3 months.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Arm I Patients receive topotecan IV continuously on days 1-21. Treatment continues at least every 4 weeks in the absence of unacceptable toxicity or disease progression. |
Drug: topotecan hydrochloride
|
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
-
Histologically confirmed malignancy that is relapsed or refractory to conventional therapy at original diagnosis including:
-
Brain tumors
-
Gliomas or astrocytomas
-
Medulloblastomas or primitive neuroectodermal tumor (PNET) in CNS
-
(Brain tumor stratum closed to accrual effective 07/02/2001)
-
Sarcomas
-
Soft tissue sarcoma (undifferentiated sarcoma, embryonal or alveolar rhabdomyosarcoma (RMS), or non-RMS soft tissue sarcoma)
-
Osteosarcoma
-
Ewing's sarcoma/peripheral PNET tumors
-
Neuroblastoma
-
(Neuroblastoma stratum closed to accrual effective 07/02/2001)
-
Histology requirement waived for brain stem tumors (Brain tumor stratum closed to accrual effective 07/02/2001)
-
Measurable disease documented by clinical, radiographic, or histologic criteria
-
Lesions in previously irradiated fields may be used to assess tumor response if there has been evidence of subsequent tumor growth in those fields
-
No bone marrow metastases with granulocytopenia and/or thrombocytopenia
PATIENT CHARACTERISTICS:
Age:
- 30 days to 21 years at diagnosis
Performance status:
- ECOG 0-2
Life expectancy:
- More than 2 months
Hematopoietic:
-
Absolute neutrophil count at least 1,000/mm3
-
Hemoglobin at least 10.0 g/dL (may receive RBC transfusions)
-
Platelet count at least 100,000/mm3 (50,000/mm3 if post bone marrow transplantation) (transfusion independent)
Hepatic:
-
Bilirubin no greater than 1.5 times normal
-
SGOT or SGPT less than 2.5 times normal
Renal:
-
Creatinine no greater than 1.5 times normal OR
-
Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min
Neurologic:
-
No greater than grade 2 CNS toxicity OR
-
Stable CNS status for brain tumors (Brain tumor stratum closed to accrual effective 07/02/2001)
-
Seizure disorders allowed if well-controlled with anticonvulsants
Other:
-
Not pregnant or nursing
-
Negative pregnancy test
-
Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
-
At least 3 months since prior bone marrow transplantation and recovered
-
At least 2 weeks since prior cytokines and recovered
-
No concurrent filgrastim (G-CSF) or other cytokines
-
No concurrent immunomodulating agents
Chemotherapy:
-
At least 2 weeks since prior chemotherapy (4 weeks for nitrosoureas) and recovered
-
No prior topotecan or other camptothecins
-
No other concurrent anticancer chemotherapy
Endocrine therapy:
- Concurrent corticosteroids for CNS tumors with increased intracranial pressure allowed (Brain tumor stratum closed to accrual effective 07/02/2001)
Radiotherapy:
-
At least 2 months since prior craniospinal radiotherapy or radiotherapy to more than 50% of the bone marrow and recovered
-
Concurrent radiotherapy to localized painful lesions allowed provided that at least 1 measurable lesion is not irradiated
Other:
- Recovered from any other prior therapy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | United States | 35233 |
2 | University of South Alabama Medical Center | Mobile | Alabama | United States | 36604 |
3 | Phoenix Children's Hospital | Phoenix | Arizona | United States | 85016-7710 |
4 | Arizona Cancer Center | Tucson | Arizona | United States | 85724 |
5 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
6 | Southern California Permanente Medical Group | Downey | California | United States | 90242 |
7 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010-3000 |
8 | Rebecca and John Moores UCSD Cancer Center | La Jolla | California | United States | 92093-0658 |
9 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
10 | Jonathan Jaques Children's Cancer Center | Long Beach | California | United States | 90801-1428 |
11 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027-0700 |
12 | Cedars-Sinai Medical Center | Los Angeles | California | United States | 90048 |
13 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
14 | Children's Hospital Central California | Madera | California | United States | 93638-8762 |
15 | Children's Hospital of Oakland | Oakland | California | United States | 94609-1809 |
16 | Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
17 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
18 | Lucile Packard Children's Hospital at Stanford | Palo Alto | California | United States | 94304 |
19 | Sutter Cancer Center | Sacramento | California | United States | 95816 |
20 | University of California Davis Medical Center | Sacramento | California | United States | 95817 |
21 | Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | United States | 92120 |
22 | Children's Hospital San Diego | San Diego | California | United States | 92123-4282 |
23 | Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco | California | United States | 94115 |
24 | UCSF Comprehensive Cancer Center | San Francisco | California | United States | 94143-0128 |
25 | Santa Barbara Cottage Hospital | Santa Barbara | California | United States | 93102 |
26 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051-5386 |
27 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
28 | Children's Hospital of Denver | Denver | Colorado | United States | 80218-1088 |
29 | Childhood Hematology/Oncology Associates | Denver | Colorado | United States | 80218 |
30 | Presbyterian-St Luke's Medical Center | Denver | Colorado | United States | 80218 |
31 | University of Connecticut Health Center | Farmington | Connecticut | United States | 06360-7106 |
32 | Yale Comprehensive Cancer Center | New Haven | Connecticut | United States | 06520-8028 |
33 | Alfred I. Dupont Institute | Wilmington | Delaware | United States | 19899 |
34 | Lombardi Cancer Center | Washington | District of Columbia | United States | 20007 |
35 | Children's National Medical Center | Washington | District of Columbia | United States | 20010-2970 |
36 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5000 |
37 | Broward General Medical Center | Fort Lauderdale | Florida | United States | 33316 |
38 | Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
39 | Shands Hospital and Clinics, University of Florida | Gainesville | Florida | United States | 32610-100277 |
40 | Joe DiMaggio Children's Hospital at Memorial | Hollywood | Florida | United States | 33021 |
41 | Nemours Children's Clinic | Jacksonville | Florida | United States | 32207 |
42 | University of Miami-Jackson Memorial Hospital | Miami | Florida | United States | 33136 |
43 | Miami Children's Hospital | Miami | Florida | United States | 33155-4069 |
44 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
45 | Florida Hospital Cancer Institute | Orlando | Florida | United States | 32803 |
46 | Nemours Children's Clinic-Orlando | Orlando | Florida | United States | 32806 |
47 | Sacred Heart Children's Hospital | Pensacola | Florida | United States | 32504 |
48 | All Children's Hospital | St. Petersburg | Florida | United States | 33701 |
49 | Tampa Children's Hospital | Tampa | Florida | United States | 33677-4227 |
50 | St. Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
51 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
52 | Children's Healthcare of Atlanta - Scottish Rite | Atlanta | Georgia | United States | 30342 |
53 | Medical College of Georgia Comprehensive Cancer Center | Augusta | Georgia | United States | 30912-4000 |
54 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
55 | Memorial Health University Medical Center, Inc. | Savannah | Georgia | United States | 31403-3089 |
56 | Cancer Research Center of Hawaii | Honolulu | Hawaii | United States | 96813 |
57 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
58 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859-5000 |
59 | Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
60 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60601 |
61 | Rush-Presbyterian-St. Luke's Medical Center | Chicago | Illinois | United States | 60612 |
62 | University of Illinois at Chicago | Chicago | Illinois | United States | 60612 |
63 | Children's Memorial Hospital - Chicago | Chicago | Illinois | United States | 60614 |
64 | Hope Children's Hospital | Oak Lawn | Illinois | United States | 60453 |
65 | Lutheran General Hospital | Park Ridge | Illinois | United States | 60068-1174 |
66 | Saint Jude Midwest Affiliate | Peoria | Illinois | United States | 61637 |
67 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62794-9658 |
68 | Indiana University Cancer Center | Indianapolis | Indiana | United States | 46202-5289 |
69 | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
70 | Raymond Blank Memorial Hospital for Children | Des Moines | Iowa | United States | 50308 |
71 | John Stoddard Cancer Center | Des Moines | Iowa | United States | 50309 |
72 | Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242-1009 |
73 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
74 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0284 |
75 | Kosair Children's Hospital | Louisville | Kentucky | United States | 40202-3830 |
76 | Tulane University School of Medicine | New Orleans | Louisiana | United States | 70112 |
77 | Children's Hospital of New Orleans | New Orleans | Louisiana | United States | 70118 |
78 | Ochsner Clinic | New Orleans | Louisiana | United States | 70121 |
79 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
80 | Maine Children's Cancer Program | Scarborough | Maine | United States | 04074 |
81 | Marlene and Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | United States | 21201-1595 |
82 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21225 |
83 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
84 | Floating Hospital for Children | Boston | Massachusetts | United States | 02111 |
85 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
86 | Baystate Medical Center | Springfield | Massachusetts | United States | 01107 |
87 | University of Massachusetts Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
88 | Mott Children's Hospital | Ann Arbor | Michigan | United States | 48109-0914 |
89 | Children's Hospital of Michigan | Detroit | Michigan | United States | 48201 |
90 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
91 | St. John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
92 | Michigan State University | East Lansing | Michigan | United States | 48824 |
93 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
94 | Spectrum Health and DeVos Children's Hospital | Grand Rapids | Michigan | United States | 49503 |
95 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
96 | CCOP - Beaumont | Royal Oak | Michigan | United States | 48073-6769 |
97 | William Beaumont Hospital | Royal Oak | Michigan | United States | 48073-6769 |
98 | St. Mary's/Duluth Clinic Cancer Center | Duluth | Minnesota | United States | 55805-1983 |
99 | Children's Hospitals and Clinics - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
100 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
101 | Children's Hospitals and Clinics of Minnesota | Saint Paul | Minnesota | United States | 55102 |
102 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216-4505 |
103 | Children's Mercy Hospital | Kansas City | Missouri | United States | 64108 |
104 | Cardinal Glennon Children's Hospital | Saint Louis | Missouri | United States | 63104 |
105 | St. Louis Children's Hospital | Saint Louis | Missouri | United States | 63110 |
106 | Children's Hospital of Omaha | Omaha | Nebraska | United States | 68114 |
107 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198-2168 |
108 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109-2306 |
109 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756-0002 |
110 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
111 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
112 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112-2094 |
113 | St. Joseph's Hospital and Medical Center | Paterson | New Jersey | United States | 07503 |
114 | Atlantic Health System | Summit | New Jersey | United States | 07901 |
115 | University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | United States | 87131 |
116 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
117 | Albert Einstein Clinical Cancer Center | Bronx | New York | United States | 10461 |
118 | Brooklyn Hospital Center | Brooklyn | New York | United States | 11201 |
119 | State University of New York Health Science Center at Brooklyn College of Medicine | Brooklyn | New York | United States | 11203 |
120 | Brookdale University Hospital and Medical Center | Brooklyn | New York | United States | 11212 |
121 | Maimonides Medical Center | Brooklyn | New York | United States | 11219 |
122 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
123 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
124 | Schneider Children's Hospital | New Hyde Park | New York | United States | 11042 |
125 | New York Presbyterian Hospital - Cornell Campus | New York | New York | United States | 10021-4885 |
126 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
127 | Mount Sinai School of Medicine | New York | New York | United States | 10029 |
128 | Columbia Presbyterian Hospital | New York | New York | United States | 10032 |
129 | James P. Wilmot Cancer Center | Rochester | New York | United States | 14642 |
130 | State University of New York Health Sciences Center - Stony Brook | Stony Brook | New York | United States | 11790-7775 |
131 | State University of New York - Upstate Medical University | Syracuse | New York | United States | 13210 |
132 | New York Medical College | Valhalla | New York | United States | 10595 |
133 | Mission Saint Joseph's Health System | Asheville | North Carolina | United States | 28801 |
134 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
135 | Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
136 | Presbyterian Healthcare | Charlotte | North Carolina | United States | 28233-3549 |
137 | Duke Comprehensive Cancer Center | Durham | North Carolina | United States | 27710 |
138 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
139 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1081 |
140 | Dakota Cancer Institute | Fargo | North Dakota | United States | 58103-4940 |
141 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
142 | Children's Hospital Medical Center - Cincinnati | Cincinnati | Ohio | United States | 45229-3039 |
143 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
144 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
145 | Children's Hospital of Columbus | Columbus | Ohio | United States | 43205-2696 |
146 | Children's Medical Center - Dayton | Dayton | Ohio | United States | 45404 |
147 | Toledo Children's Hospital | Toledo | Ohio | United States | 43601 |
148 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
149 | Forum Health-Tod Childrens Hospital | Youngstown | Ohio | United States | 44501 |
150 | Children's Hospital of Oklahoma | Oklahoma City | Oklahoma | United States | 73104 |
151 | CCOP - Oklahoma | Tulsa | Oklahoma | United States | 74136 |
152 | Natalie Warren Bryant Cancer Center | Tulsa | Oklahoma | United States | 74136 |
153 | Doernbecher Children's Hospital | Portland | Oregon | United States | 97201-3098 |
154 | Legacy Emanuel Hospital and Health Center | Portland | Oregon | United States | 97227 |
155 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-1320 |
156 | Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
157 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
158 | St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | United States | 19134-1095 |
159 | Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15213 |
160 | Rhode Island Hospital | Providence | Rhode Island | United States | 02818 |
161 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
162 | Palmetto Health South Carolina Cancer Center | Columbia | South Carolina | United States | 29203 |
163 | Children's Hospital of Greenville Hospital System | Greenville | South Carolina | United States | 29605 |
164 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105-1080 |
165 | Sioux Valley Hospital | Sioux Falls | South Dakota | United States | 57117 |
166 | East Tennessee State University Cancer Center at JCMC | Johnson City | Tennessee | United States | 37604 |
167 | East Tennessee Children's Hospital | Knoxville | Tennessee | United States | 37901 |
168 | Saint Jude Children's Research Hospital | Memphis | Tennessee | United States | 38105-2794 |
169 | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | United States | 37232-6838 |
170 | Texas Tech University Health Sciences Center School of Medicine | Amarillo | Texas | United States | 79106 |
171 | Children's Hospital of Austin | Austin | Texas | United States | 78701 |
172 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
173 | Simmons Cancer Center - Dallas | Dallas | Texas | United States | 75235-9154 |
174 | Cook Children's Medical Center - Fort Worth | Fort Worth | Texas | United States | 76104 |
175 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0361 |
176 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
177 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
178 | San Antonio Military Pediatric Cancer and Blood Disorders Center | Lackland Air Force Base | Texas | United States | 78236-5300 |
179 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
180 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78207 |
181 | Methodist Health Care System | San Antonio | Texas | United States | 78229-3902 |
182 | Scott and White Memorial Hospital | Temple | Texas | United States | 76508 |
183 | Huntsman Cancer Institute | Salt Lake City | Utah | United States | 84112 |
184 | Vermont Cancer Center | Burlington | Vermont | United States | 05401-3498 |
185 | Cancer Center at the University of Virginia | Charlottesville | Virginia | United States | 22908 |
186 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042-3300 |
187 | Children's Hospital of the King's Daughters | Norfolk | Virginia | United States | 23507 |
188 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-5100 |
189 | Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
190 | Carilion Medical Center for Children | Roanoke | Virginia | United States | 24013 |
191 | Children's Hospital and Regional Medical Center - Seattle | Seattle | Washington | United States | 98105 |
192 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109-1024 |
193 | Group Health Cooperative | Seattle | Washington | United States | 98112 |
194 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
195 | Mary Bridge Children's Health Center | Tacoma | Washington | United States | 98415-0299 |
196 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431-5000 |
197 | West Virginia University - Charleston | Charleston | West Virginia | United States | 25302 |
198 | Cabell-Huntington Hospital, Inc | Huntington | West Virginia | United States | 25701 |
199 | West Virginia University Hospitals | Morgantown | West Virginia | United States | 26506-9300 |
200 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
201 | CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | United States | 54301 |
202 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-9070 |
203 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
204 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792-0001 |
205 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449-5772 |
206 | Midwest Children's Cancer Center | Milwaukee | Wisconsin | United States | 53226 |
207 | Sydney Children's Hospital | Randwick | New South Wales | Australia | 2031 |
208 | Children's Hospital at Westmead | Westmead | New South Wales | Australia | 2145 |
209 | Royal Children's Hospital | Brisbane | Queensland | Australia | 4029 |
210 | Women's and Children's Hospital | North Adelaide | South Australia | Australia | 5006 |
211 | Royal Children's Hospital | Parkville | Victoria | Australia | 3052 |
212 | Princess Margaret Hospital for Children | Perth | Western Australia | Australia | 6001 |
213 | Alberta Children's Hospital | Calgary | Alberta | Canada | T2T 5C7 |
214 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
215 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
216 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
217 | Janeway Children's Health and Rehabilitation Centre | St. John's | Newfoundland and Labrador | Canada | A1B 3V6 |
218 | IWK Health Centre | Halifax | Nova Scotia | Canada | B3J 3G9 |
219 | Children's Hospital | Hamilton | Ontario | Canada | L8N 3Z5 |
220 | Children's Hospital of Western Ontario | London | Ontario | Canada | N6C 2V5 |
221 | Children's Hospital of Eastern Ontario | Ottawa | Ontario | Canada | K1H 8L1 |
222 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
223 | McGill University Health Center - Montreal Children's Hospital | Montreal | Quebec | Canada | H3H 1P3 |
224 | Hopital Sainte Justine | Montreal | Quebec | Canada | H3T 1C5 |
225 | Centre Hospitalier de L'Universite Laval | Sainte Foy | Quebec | Canada | GIV 4G2 |
226 | Laval University Medical Center | Sainte-Foy | Quebec | Canada | G1V 4G2 |
227 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
228 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
229 | Academisch Ziekenhuis Groningen | Groningen | Netherlands | 9700 RB | |
230 | Starship Children's Hospital | Auckland | New Zealand | ||
231 | University of Puerto Rico School of Medicine Medical Sciences Campus | San Juan | Puerto Rico | 00936-5067 | |
232 | San Jorge Childrens Hospital | Santurce | Puerto Rico | 00912 | |
233 | Swiss Pediatric Oncology Group Bern | Bern | Switzerland | CH 3010 | |
234 | Swiss Pediatric Oncology Group Geneva | Geneva | Switzerland | CH 1211 | |
235 | Swiss Pediatric Oncology Group Lausanne | Lausanne | Switzerland | CH 1011 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Study Chair: Douglas Hawkins, MD, Seattle Children's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2012-01841
- COG-A09713
- CCG-A09713
- CCG-09713
- CDR0000066864