A Phase I Study of TNP-470 in the Treatment of AIDS-Associated Kaposi's Sarcoma

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID) (NIH)

Overall Status

Completed

CT.gov ID

NCT00000763

Collaborator

(none)

Enrollment

Locations

Patients Per Site

Study Details

Study Description

Brief Summary

To assess toxicity and determine the MTD of intravenous TNP-470 administered weekly in patients with AIDS-related Kaposi's sarcoma. To assess pharmacokinetics and tumor response of the drug.

Since evidence shows that neovascularization is important in the development of Kaposi's sarcoma, drugs that inhibit angiogenesis, such as TNP-470, may be of benefit in patients with the disease.

Condition or Disease	Intervention/Treatment	Phase
Sarcoma, Kaposi HIV Infections	Drug: TNP-470	Phase 1

Detailed Description

Since evidence shows that neovascularization is important in the development of Kaposi's sarcoma, drugs that inhibit angiogenesis, such as TNP-470, may be of benefit in patients with the disease.

Patients are entered at 7 escalating dose levels of TNP-470. (PER AMENDMENT 9/3/96: dose maximum level changed.) Four patients treated at a given dose level must receive at least 4 weeks of therapy before escalation in subsequent cohorts proceeds. If 50 percent of patients at a given dose level experience dose-limiting toxicity, the previous dose is defined as the MTD and an additional two patients are treated at the MTD. Patients receive treatment for 12 weeks, followed by 2 weeks of rest, followed by an additional 12 weeks of treatment. Patients are followed for 12 weeks post-treatment.

Study Design

Study Type:

Interventional

Primary Purpose:

Treatment

Official Title:

A Phase I Study of TNP-470 in the Treatment of AIDS-Associated Kaposi's Sarcoma

Actual Study Completion Date :

Feb 1, 1997

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

12 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria

Concurrent Medication:

Allowed:

AZT, ddI, ddC, or d4T provided patients have received at least 2 weeks of this therapy prior to study entry. (Combination ddI/ddC is not permitted.)
MAI prophylaxis.

Required in patients with CD4 count < 200 cells/mm3:

Aerosolized pentamidine, trimethoprim/sulfamethoxazole, or dapsone as PCP prophylaxis.

Patients must have:

HIV infection.
Cutaneous Kaposi's sarcoma.
Life expectancy of at least 3 months.
Consent of parent or guardian if under 18 years of age.

NOTE:

This protocol is considered suitable for prison populations.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

Peripheral neuropathy (grade 2 or worse).
Underlying severe or life-threatening infection with bacterial, viral, fungal, or protozoal pathogens.
Known hypersensitivity to TNP-470, fumagillin, or known related compounds.

PER AMENDMENT 9/3/96:

Cataracts.

Concurrent Medication:

Excluded:

Combination therapy with ddI/ddC (although these drugs may be administered alone or in combination with AZT).
Anticonvulsive medication.
Steroids.
Antineoplastic drugs.
Interferons.
Systemic or topical anti-Kaposi's sarcoma agents or regimens.
Suramin.
Aspirin.
Warfarin.
Heparin (including heparin flushes).
Nonsteroidal anti-inflammatory drugs.
Investigational status drugs.

Patients with the following prior conditions are excluded:

History of substantial non-iatrogenic bleeding disorders.
History of tumor or malignancies other than Kaposi's sarcoma, with the exception of completely resected basal cell skin carcinoma or in situ cervical carcinoma.
History of seizures within the past 10 years.

PER AMENDMENT 9/3/96:

History of cataracts.

Prior Medication:

Excluded within 4 weeks prior to study entry:

Steroids.
Antineoplastic drugs.
Interferons.
Systemic or topical anti-Kaposi's sarcoma agents or regimens.

Excluded within 6 months prior to study entry:

Suramin.

Unwilling to refrain from unprotected sexual contact or other activities that may result in HIV re-infection.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	USC CRS	Los Angeles	California	United States	90033
2	Northwestern University CRS	Chicago	Illinois	United States	60611
3	Bmc Actg Crs	Boston	Massachusetts	United States	02118
4	Beth Israel Deaconess - East Campus A0102 CRS	Boston	Massachusetts	United States	02215
5	Washington U CRS	Saint Louis	Missouri	United States
6	Beth Israel Med. Ctr. (Mt. Sinai)	New York	New York	United States