MASK: Middle Age muScle Krill Study
Study Details
Study Description
Brief Summary
This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Intervention Krill oil 4g/day for 24 weeks |
Dietary Supplement: Krill oil
Superba krill oil
|
| Placebo Comparator: Placebo Vegetable oil 4g/day for 24 weeks |
Dietary Supplement: Vegetable oil
Mixed vegetable oil
|
Outcome Measures
Primary Outcome Measures
- Change in knee extensor maximal isometric torque ( MVC) [Change from baseline to 24 weeks]
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
Secondary Outcome Measures
- Change in fat mass [Change from baseline to 24 weeks]
Whole body fat mass measured by measured via bio-electrical impedance
- Change in lean mass [Change from baseline to 24 weeks]
Whole body lean mass measured by measured via bio-electrical impedance
- Change in omega-3 levels [Change from baseline to 24 weeks]
Red blood cell omega-3 levels
- Change in Grip strength [Change from baseline to 24 weeks]
Grip strength measured with a hand held dynamometer
- Change in Muscle thickness [Change from baseline to 24 weeks]
Vastus lateralis muscle thickness measured by ultrasound
Other Outcome Measures
- Change in systemic inflammation [Change from baseline to 24 weeks]
Plasma levels of C-reactive protein, IL-1, IL-6, IL-8, IL-10, and TNF-α
- Change in muscle inflammation [Change from baseline to 24 weeks]
Muscle total protein levels of TNF-α, IL-1β, IL-6, IL-8, MCP-1 and total and phosphorylated levels of NFκB, JNK1/2 and STAT3
- Change in muscle anabolic signalling [Change from baseline to 24 weeks]
Muscle total and phosphorylated protein levels of mTOR, IRS-1, Akt, 4EBP-1, p70S6K, RPS6, FOXO-1, GSK3β and total protein levels of MAFBx and MURF-1
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Be 35-60 years old
-
Have a BMI of less than 35kg/m2
Exclusion Criteria:
-
People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
-
People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
-
People who perform regular (>1 day/week) resistance exercise training.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Glasgow | Glasgow | United Kingdom |
Sponsors and Collaborators
- University of Glasgow
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MASK