The Relationship Between Blood Glucose and Satiety Ratings

Sponsor
Western University, Canada (Other)
Overall Status
Unknown status
CT.gov ID
NCT04183855
Collaborator
(none)
24
1
3
7
3.4

Study Details

Study Description

Brief Summary

Participants will be given a drink (and no drink for one of the treatments) prior to a pizza dinner. Ratings on satiety, appetite and desire to eat will be asked with the use of a questionnaire. Blood glucose will also be measured. One hour after the drink, participants will be given a pizza and can eat as much as they want. The pizza remaining will be weighed.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Generation UCAN supplementation
  • Dietary Supplement: Mirexus PhytoSpherix supplementation
  • Behavioral: satiety ratings
N/A

Detailed Description

Each participant will receive all three treatments on separate occasions in random order (separated by a week). The three treatments include control (no supplement), carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution) and carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution). Participants will report to the lab between 4-5 pm and 4 hours after their last meal on day they have not exercised. Participants will record food intake the day of the first experiment and will be asked to replicate both type and quantity for subsequent visits. Upon arrival at the lab, baseline measures (blood glucose as well as rating of satiety ratings, appetite and desire to eat (10-point visual analogue scale). Then the treatment will be given and all the aforementioned variables will be remeasured at 15, 30, 45 and 60 minutes post drink. At 65 minutes, participants will be provided with an ad libitum pizza meal. Participants will be told to eat until they are "comfortably full" (Bellissimo et al., 2008). The pizza provided will be weighed initially and once the participant is done eating and has left the lab, the remaining pizza will be weighed and recorded. The pizza will be a cheese only pizza to minimize any difference in energy intake due to the location of additional items placed on the pizza.

Participants will not be told the true purpose of this experiment, instead they will be told that the pizza meal is a reward for participating in the study. Later, at the conclusion of the study all will be debriefed.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
24 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Single (Participant)
Primary Purpose:
Other
Official Title:
The Relationship Between Blood Glucose and Satiety Ratings
Anticipated Study Start Date :
Feb 1, 2020
Anticipated Primary Completion Date :
Jun 30, 2020
Anticipated Study Completion Date :
Aug 31, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: control

no supplement will be provided on the day of the experiment

Behavioral: satiety ratings
questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)

Experimental: Generation UCAN

carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)

Dietary Supplement: Generation UCAN supplementation
carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)

Behavioral: satiety ratings
questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)

Experimental: Mirexus PhytoSpherix

carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)

Dietary Supplement: Mirexus PhytoSpherix supplementation
carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)

Behavioral: satiety ratings
questionnaire on satiety ratings will be provided to participants 15, 30, 45 and 60 min after the drink (or no drink)

Outcome Measures

Primary Outcome Measures

  1. changes in satiety ratings after the drink [15, 30, 45, 60 min after the drink]

    satiety ratings will be asked with the use a 10 point visual analog scale (VAS) questionnaire, 10 being do not want to consume any more food and 1 being strong desire to consume food

  2. Food intake [90 min after the drink]

    food intake after each treatment will be measured by weighing the left over pizza slices

Secondary Outcome Measures

  1. changes in appetite ratings after the drink [15, 30, 45, 60 min after the drink]

    appetite ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being strong desire to consume food and 1 being no desire to consume food at all

  2. changes in blood glucose after the drink [15, 30, 45, 60 min after the drink]

    blood glucose will be measured through finger pricks

  3. changes in desire to eat ratings [15, 30, 45, 60 min after the drink]

    desire to eat ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being no desire to eat at all and 1 being strong desire to eat

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 40 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Healthy males and females at the age of 18-40

  • sedentary individuals

Exclusion Criteria:
  • exercise more than twice per week

  • does not like pizza

  • do not eat three meals a day

  • medications that affect eating patterns

  • have metabolic and gastrointestinal diseases

Contacts and Locations

Locations

Site City State Country Postal Code
1 Exercise Nutrition Laboratory (Western University) London Ontario Canada N6A 3K7

Sponsors and Collaborators

  • Western University, Canada

Investigators

  • Principal Investigator: Peter Lemon, PhD, Western University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Peter Lemon, Principal Investigator, Western University, Canada
ClinicalTrials.gov Identifier:
NCT04183855
Other Study ID Numbers:
  • 115099
First Posted:
Dec 3, 2019
Last Update Posted:
Jan 18, 2020
Last Verified:
Nov 1, 2019
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of Jan 18, 2020