Incorporating Avocados in Meals

Sponsor

Loma Linda University (Other)

Overall Status

Completed

CT.gov ID

NCT01271829

Collaborator

Hass Avocado Board (Other)

Enrollment

Location

Arms

Duration (Months)

1.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.

Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

Condition or Disease	Intervention/Treatment	Phase
Satiety Glycemic Index Insulin Gastrointestinal Peptides and Hormones	Dietary Supplement: Avocado supplement Dietary Supplement: Avocado included	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

30 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Single (Investigator)

Official Title:

Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans

Study Start Date :

Jan 1, 2011

Actual Primary Completion Date :

Sep 1, 2012

Actual Study Completion Date :

Sep 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
No Intervention: Control While on the control arm subjects will be given a meal with no avocado.
Active Comparator: Avocado supplement While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados.	Dietary Supplement: Avocado supplement Calories from avocados replace calories of the control lunch
Active Comparator: Avocado included While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal.	Dietary Supplement: Avocado included Calories from avocados will be added to calories from the control lunch

Arm

Intervention/Treatment

No Intervention: Control

While on the control arm subjects will be given a meal with no avocado.

Active Comparator: Avocado supplement

While on the avocado supplement arm subjects will be given a meal in which a given amount of calories will be replaced by calories contributed by avocados.

Dietary Supplement: Avocado supplement

Calories from avocados replace calories of the control lunch

Active Comparator: Avocado included

While on the avocado included arm subjects will be given a meal in which the calories of avocado will be added to the calories of the control meal.

Dietary Supplement: Avocado included

Calories from avocados will be added to calories from the control lunch

Outcome Measures

Primary Outcome Measures

Satiety [12 hours]
The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode

Secondary Outcome Measures

post-ingestion glycemic index [3 hours]
Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed.
insulin response [3 hours]
Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.
appetite-related gastrointestinal peptide and hormone release [3 hours]
Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed.

Eligibility Criteria

Criteria

Ages Eligible for Study:

23 Years to 60 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

23-60 years old
BMI 23-32
Stable weight for 6 months
Live or work near Loma Linda University

Exclusion Criteria:

Smoker
Heavy involvement in sports
Dependent on caffeine

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Loma Linda University, Department of Nutrition	Loma Linda	California	United States	92350

Sponsors and Collaborators

Loma Linda University
Hass Avocado Board

Investigators

Principal Investigator: Joan Sabaté, MD, DrPH, Loma Linda University

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publication of study results

Publications

None provided.

Responsible Party:

Joan Sabate,DrPH, MD, Chair, Department of Nutrition, Loma Linda University

ClinicalTrials.gov Identifier:

NCT01271829

Other Study ID Numbers:

5100220

First Posted:

Jan 7, 2011

Last Update Posted:

Mar 18, 2014

Last Verified:

Mar 1, 2014

Keywords provided by Joan Sabate,DrPH, MD, Chair, Department of Nutrition, Loma Linda University

Avocados

Satiety

Feeding study

Study Results

No Results Posted as of Mar 18, 2014