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Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight

Sponsor
Zhejiang University (Other)
Overall Status
Completed
CT.gov ID
NCT03281512
Collaborator
National Institute of Health and Nutrition (Other)
14,383
Enrollment
288
Actual Duration (Months)

Study Details

Study Description

Brief Summary

The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    14383 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight in the China Health and Nutrition Survey (CHNS)
    Actual Study Start Date :
    Jan 1, 1989
    Actual Primary Completion Date :
    Dec 31, 2011
    Actual Study Completion Date :
    Dec 31, 2012

    Outcome Measures

    Primary Outcome Measures

    1. Mortality [From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years]

      Incidence of all-cause death, on basis of household members' report

    2. Diabetes [From entry into the study (baseline: 1997-2009) until 2011]

      Incidence of diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%

    Secondary Outcome Measures

    1. Saturated fatty acids intake [From entry into the study (baseline: 1997-2009) until 2011]

      Cumulative average intake of saturated fatty acids on basis of 3 consecutive 24-h dietary recalls

    2. Hypertension [From entry into the study (baseline: 1997-2009) until 2011]

      Incidence of hypertension, on basis of self-reported physician diagnosis, systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg

    3. Overweight [From entry into the study (baseline: 1997-2009) until 2011]

      Incidence of overweight, on basis of body mass index (BMI), BMI ≥ 24 kg/㎡

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Adults aged ≥20 with complete data on diet and follow-up time
    Exclusion Criteria:

    • Cardiovascular diseases

    • Diabetes (for analyses of diabetes)

    • Body mass index ≥ 24 kg/㎡ (for analyses of overweight)

    • Hypertension (for analyses of hypertension)

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Zhejiang University
    • National Institute of Health and Nutrition

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Jingjing Jiao, Associate Professor, Zhejiang University
    ClinicalTrials.gov Identifier:
    NCT03281512
    Other Study ID Numbers:
    • Cohort_SFA
    First Posted:
    Sep 13, 2017
    Last Update Posted:
    Sep 13, 2017
    Last Verified:
    Sep 1, 2017
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Jingjing Jiao, Associate Professor, Zhejiang University
    Saturated fatty acids
    CHNS
    Additional relevant MeSH terms:
    Hypertension
    Diabetes Mellitus
    Overweight

    Study Results

    No Results Posted as of Sep 13, 2017