A Scalp Lotion Toimprove Sensitive Scalp Syndrome
Study Details
Study Description
Brief Summary
Overall, 100 Caucasian subjects participated in this 6-weeks lasting study, AC5+ was applied daily. All subjects had clinically confirmed mild to moderate alopecia and self-declared sensitive scalp. Instrumental assessments included Trans Epidermal Water Loss (TEWL), inflammation markers, clinical assessments included the severity of erythema, inflammation and greasiness. Subjective/Self assessments comprised the intensity of the scalp itch/pruritus and the evaluation of their head hair status (volume, abundance, strength). Same assessments were provided by the investigators.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Outcome Measures
Primary Outcome Measures
- erythema [Baseline]
on a scale from o=none to 5=severe
- erythema [Day 21]
on a scale from o=none to 5=severe
- inflammation [Baseline]
on a scale from o=none to 5=severe
- inflammation [Day 21]
on a scale from o=none to 5=severe
- greasiness [Baseline]
on a scale from o=none to 5=severe
- greasiness [Day 21]
on a scale from o=none to 5=severe
- Global soothing score [Baseline]
sum of the symptoms with a score up to 15
- Global soothing score [Day 21]
sum of the symptoms with a score up to 15
Secondary Outcome Measures
- pruritus [Baseline]
on a scale from o=none to 5=severe
- pruritus [Day 21]
on a scale from o=none to 5=severe
- burning [Baseline]
on a scale from o=none to 5=severe
- burning [Day 21]
on a scale from o=none to 5=severe
- stinging [Baseline]
on a scale from o=none to 5=severe
- stinging [Day 21]
on a scale from o=none to 5=severe
- scratching [Baseline]
on a scale from o=none to 5=severe
- scratching [Day 21]
on a scale from o=none to 5=severe
- hair quality [Baseline]
on a scale from o=none to 5=severe
- hair quality [Day 21]
on a scale from o=none to 5=severe
- Transepidermal water loss [Baseline]
instrumental measurements
- Transepidermal water loss [Day 21]
instrumental measurements
- Inflammation markers [Baseline]
skin swabs analysis
- Inflammation markers [Day 21]
skin swabs analysis skin swabs analysis
- squalene [Baseline]
skin swabs analysis skin swabs analysis
- squalene [Day 21]
skin swabs analysis skin swabs analysis
- Squalene monohydroperoxide [Baseline]
skin swabs analysis
- Squalene monohydroperoxide [Day 21]
skin swabs analysis
Eligibility Criteria
Criteria
Inclusion Criteria:
-
18 years
-
mild alopecia:
-
female: Ludwig type 1
-
male: Hamilton III to IV type
Exclusion Criteria:
-
Moderate or severe alopecia
-
Dandruff
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | L'OREAL Research and Innovation | Saint-Ouen | France |
Sponsors and Collaborators
- Cosmetique Active International
Investigators
- Study Director: Philippe Massiot, L'OREAL Research and Innovation, Saint-Ouen, France
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AC5+