Emotional Response in Psychiatric and Control Participants

Sponsor
University of California, Irvine (Other)
Overall Status
Completed
CT.gov ID
NCT03056781
Collaborator
(none)
46
1
2
17.5
2.6

Study Details

Study Description

Brief Summary

The purpose of this research is to understand how the emotions of people with different mental health concerns (e.g., people with schizophrenia, people with major depressive disorder) differ from individuals without mental health concerns. A large body of literature suggests that people with mental illnesses have emotional abnormalities compared to healthy individuals, but a number of these abnormalities are not well understood. For example, often people with schizophrenia report on questionnaires that they experience fewer pleasant emotions when talking with other people, but some evidence suggests these individuals report a similar amount of pleasant emotion when they are actually engaged in a pleasant activity. Thus, it is unclear the extent to which reports of emotional abnormalities extend to a more real-world setting. In the tasks in the current proposal, participants will engage in a series of tasks designed to assess their emotional functioning. These tasks involve viewing emotional stimuli on the computer, engaging in social interactions, and consuming small amounts of food. In all tasks, participants will make ratings of their experiences of pleasure (and displeasure). We will then compare the experiences of patient groups to those of healthy individuals to test how emotional ratings might differ across these tasks.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: social interaction
  • Behavioral: food consumption
N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
46 participants
Allocation:
Non-Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Basic Science
Official Title:
Emotional Response in Psychiatric and Control Participants
Actual Study Start Date :
Feb 15, 2017
Actual Primary Completion Date :
Aug 1, 2018
Actual Study Completion Date :
Aug 1, 2018

Arms and Interventions

Arm Intervention/Treatment
Experimental: social interaction

Participants will engage in a social interaction with another person

Behavioral: social interaction
Participants will engage in a social interaction with another person

Experimental: food consumption

Participants will be offered food stuffs to eat/drink

Behavioral: food consumption
Participants will be offered food stuffs to eat/drink

Outcome Measures

Primary Outcome Measures

  1. Social Anhedonia Scale [1 day]

    measures social anhedonia

  2. Physical Anhedonia Scale [1 day]

    measures physical anhedonia

  3. EEG activity [1 day]

    physiological parameter

  4. Verbal behavioral rating [1 day]

    how many words are spoken throughout the task

  5. Non-verbal behavioral rating [1 day]

    how many gestures are made throughout the task

  6. International Personality Item Pool questionnaires [1 day]

    measure of personality

Secondary Outcome Measures

  1. Following Affective States test [1 day]

    questionnaire re: how much participants follow or ignore their emotions

  2. AMNART [1 day]

    measure of verbal IQ

  3. MMSE [1 day]

    measure of mental status

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • For control participants, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have not been clinically diagnosed with a psychiatric disorder.

  • For psychiatric patients, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have been clinically diagnosed with schizophrenia, schizoaffective disorder, or depression with no recent hospitalization or changes in your psychiatric medications.

Exclusion Criteria:
  • For control participants, you are not eligible to participate in the study if you have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months. You are not eligible to participate if you have a current or past history of a major medical illness, significant tremors, a history of a head injury or prolonged unconsciousness.

  • For psychiatric patients, you are not eligible to participate in the study if you have had major changes to your psychotropic medications within the last two months, have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months, a current or past history of a major medical illness, significant tremors, or a history of a head injury or prolonged unconsciousness.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Social Ecology 1 Irvine California United States 92697-0001

Sponsors and Collaborators

  • University of California, Irvine

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Elizabeth A. Martin, Assistant Professor, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT03056781
Other Study ID Numbers:
  • 2016-2945
First Posted:
Feb 17, 2017
Last Update Posted:
Dec 14, 2018
Last Verified:
Dec 1, 2018
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Dec 14, 2018