Sclerotherapy and Bone Marrow Injection In Aneurysmal Bone Cyst
Study Details
Study Description
Brief Summary
Aneurysmal bone cysts (ABCs) are benign, locally destructive growing bone tumors, which were first described in 1942 by Jaffé and Lichtenstein (1). They are most often diagnosed in childhood and early adulthood. The literature reports that ABCs comprise 1-6% of all primary benign bone tumors (2). Most cases of ABCs (75-90%) are reported for patients younger than 20 years, with a slightly higher incidence for females (3). Most common localizations are the pelvis, the metaphysis of long bones and the spine, but ABCs can also affect any other localization(2). ABCs that are associated with a preexisting osseous lesion are defined as secondary ABCs. They represent approximately 30% of all ABCs (2). Secondary ABCs can occur, e.g., in cases of a giant cell tumor, chondroblastoma or telangiectatic osteosarcoma
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The clinical symptoms of an ABC are usually accidently discovered or may consist of pain and swelling in the affected region and pathological fractures ( complete and incomplete ) can be observed occasionally. In conventional radiography a relatively well-defined osteolytic, expansile lesion with possible blowout of the periosteum and a soap-bubble appearance can be found (4). MRI scanning shows cystic formations with typical fluid-fluid levels due to blood sedimentation (7). Because of the possible rapid growth with local destruction, the literature describes cases of ABCs that mimic malignant bone tumors
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| sclerotherapy and bone marrow Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst |
Procedure: Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst
Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst
|
Outcome Measures
Primary Outcome Measures
- Healing [1 year]
Results will discuss in this study, according to assessment of ABC healing ( complete or not ) , and also following assessment of recurrence rate and incidence of complication.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
All Patients above age of 1 year.
-
The affected area was all bones except skull, ribs, and other non-orthopedic specialties.
-
Primary or recurrent ABC
-
Incomplete Fractured affected bones as greenstick fracture.
-
Healed Pathological fracture without any surgical intervention
Exclusion Criteria:
-
ABC. In skull, ribs, and other non-orthopedic specialties.
-
Age less than 1 year
-
Suspected malignancy or other bone cysts
-
Complete fractured bones and healed pathological fracture with surgical intervention.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Al-Azhar University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Dormans JP, Hanna BG, Johnston DR, Khurana JS. Surgical treatment and recurrence rate of aneurysmal bone cysts in children. Clin Orthop Relat Res. 2004 Apr;(421):205-11. doi: 10.1097/01.blo.0000126336.46604.e1.
- Shiels WE 2nd, Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clin Orthop Relat Res. 2013 Aug;471(8):2675-83. doi: 10.1007/s11999-013-3043-2. Epub 2013 May 14.
- SABMIMABC