Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients

Sponsor

M.D. Anderson Cancer Center (Other)

Overall Status

Completed

CT.gov ID

NCT00508846

Collaborator

(none)

Enrollment

Location

154

Duration (Months)

0.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Among women with HNPCC, this study will assess:

Knowledge of screening recommendations for endometrial and ovarian cancers.
Perceived risk and cancer worries regarding endometrial, ovarian and colorectal cancers.
Adherence to screening recommendations for endometrial, ovarian and colon cancers.
Perceived benefits,supports and barriers to endometrial and ovarian cancer screening.
Patterns of communication about endometrial and ovarian cancer risk within families with HNPCC and with health care providers.
Patient preferences for potential cancer screening and cancer prevention strategies related to HNPCC-associated cancers.

Condition or Disease	Intervention/Treatment	Phase
Colon Cancer	Behavioral: Questionnaire

Detailed Description

Women who are at risk for HNPCC will be recruited to participate in this pilot study.

Women will be invited to participate in the study either through a mailed invitation or during a visit to M.D. Anderson for clinical services or for research purposes.

Women who wish to participate in the study will complete an informed consent, and will subsequently schedule an appointment with a research coordinator to complete the study questionnaire by telephone.

Study Design

Study Type:

Observational

Actual Enrollment :

93 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Screening for Gynecologic Cancers Among Women With Hereditary Non-Polyposis Colon Cancer (HNPCC)

Study Start Date :

May 1, 2003

Actual Primary Completion Date :

Mar 1, 2016

Actual Study Completion Date :

Mar 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
HNPCC Patients	Behavioral: Questionnaire Two-part telephone questionnaire lasting about 60 minutes total. Other Names: Survey

Arm

Intervention/Treatment

HNPCC Patients

Behavioral: Questionnaire

Two-part telephone questionnaire lasting about 60 minutes total.

Other Names:

Survey

Outcome Measures

Primary Outcome Measures

Patient Responses to Questionnaire [7 Years]
Outcomes measuring demographics, surveillance behaviors, perceived risk, and cancer worries, screening supports/benefits and barriers.

Eligibility Criteria

Criteria

Ages Eligible for Study:

25 Years and Older

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Inclusion Criteria:

Being female
Being 25 years of age or older
Having an HNPCC-predisposing mutation and/or having a family history of cancer that meets the Amsterdam or Amsterdam II criteria for HNPCC

Exclusion Criteria:

Persons who have tested negative for a known HNPCC-predisposing mutation in their family
Persons who have no family HNPCC mutation and have not met the Amsterdam I/II criteria
Being younger than 25 years old
Note: Women who have had a prior history of colorectal cancer or polyps will not be excluded unless they meet one of the above exclusion criteria.