Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)

Sponsor

Xijing Hospital (Other)

Overall Status

Unknown status

CT.gov ID

NCT02084030

Collaborator

(none)

120

Enrollment

Location

Duration (Months)

6.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD

Condition or Disease	Intervention/Treatment	Phase
Cardiac Surgery Patients

Detailed Description

BACKGROUND: Postoperative cognitive dysfunction is probably the most frequent type of postoperative cognitive impairment. As it mainly affect the elderly population, POCD is receiving increasing attention. However, the pathophysiology of POCD remains incompletely understood. No study had elucidate why somebody are apt to suffer from POCD, but others not. In current study, we try to use GWAS technology to find out whether there is a correlation between POCD and gene specificity.

DESIGNING: 120 patients will be screened who are schedule to receive selective on-pump cardiac surgery， 5 ml blood of the patient will be collected before anesthesia induction. Investigetors will measure the cognitive function of the patients one day before surgery and 7 d after surgery and identify whether the patient suffer from POCD used in MMSE test. Randomly select 36 patients who suffer from POCD and 36 patients without POCD(control), GWAS technology will be used to screen the susceptibility gene between these two groups.

EXPECTED RESULTS ：Find out some susceptibility genes correlate to POCD.

CONCLUSIONS: The patients who are apt to suffer from POCD have some special susceptibility genes differ from normal people.

Study Design

Study Type:

Observational

Anticipated Enrollment :

120 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction After On-pump Cardiac Surgery

Study Start Date :

Mar 1, 2013

Anticipated Primary Completion Date :

Sep 1, 2014

Anticipated Study Completion Date :

Sep 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Patient with POCD Patients who suffer from POCD after surgery. The mini-mental state examination scale decline more than 1 SD of baseline after surgery.
Sham Comparator: patient without POCD Patients who don't suffer from POCD after surgery. There is no obvious difference between pre-operation and post-operation in mini-mental state examination scale

Outcome Measures

Primary Outcome Measures

single nucleotide polymorphisms(SNPs) of each patient [about 10 minutes before anesthesia induction]

Secondary Outcome Measures

mini-mental state examination scale [one day before surgery, 7 d after surgery]
the cognitive function

Eligibility Criteria

Criteria

Ages Eligible for Study:

60 Years to 75 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Age from 60 to 75 years old;
Schedule for on-pump cardiac surgery;
undergoing full intravenous anesthesia;
without hepatic, renal, pulmonary disease or full intravenous anesthesia surgery history;
Gave the informed consent.