Effects of Sedentary Behaviour on Metabolic Parameters
Study Details
Study Description
Brief Summary
The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions.
Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention.
This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Activity During a 4 hour Meal Test subjects will cycle for 2 minutes every 20 minutes |
Other: Activity
Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.
|
| Other: Inactivity During a 4 hour Meal Test study subjects will remain inactive (remain lying on a bed) |
Other: Inactivity
Subjects will remain inactive (lying on a bed) for 4 hours.
|
Outcome Measures
Primary Outcome Measures
- Blood Pressure [every 60 minutes for 4 hours]
Secondary Outcome Measures
- C Reactive Protein [every 60 minutes for 4 hours]
- Insulin Levels [every 60 minutes for 4 hours]
- Blood glucose levels [every 60 minutes for 4 hours]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
65 years of age or older
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type 2 diabetes managed with diet or oral hypoglycemic agents
Exclusion Criteria:
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using insulin to manage diabetes
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baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L
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any medical condition that would limit the ability to perform activity portion of the study
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people not comfortable exercising on a stationary bicycle
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subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Gerontology Research Lab | Vancouver | British Columbia | Canada | V5Z 1M9 |
Sponsors and Collaborators
- University of British Columbia
Investigators
- Principal Investigator: Kenneth M Madden, MSc, MD, University of British Columbia
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- H13-01886