The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients
Study Details
Study Description
Brief Summary
Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in identifying cancer patients in the high risk population or suspected patients. Trained dogs will sniff serum from participants who are suspected to suffer from tumor by their physicians and not yet but will be diagnosed by pathological examination.The results will be compared with the outcome of the pathological examination.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Healthy volunteers Healthy volunteers measured by currently used healthy screening procedures |
|
| Suspected breast cancer subjects Suspected breast cancer subjects without pathological examination yet but will have it soon |
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| Suspected lung cancer subjects Suspected lung cancer subjects without pathological examination yet but will have it soon |
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| Suspected neurological tumor subjects Suspected neurological tumor subjects without pathological examination yet but will have it soon |
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| Suspected patients with gynecological tumor Suspected subjects with gynecological tumors without pathological examination yet but will have it soon |
Outcome Measures
Primary Outcome Measures
- sensitivity and specificity of the sniff dogs as a tool in diagnosing tumors [12 months]
The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination as non-cancer subjects.
Secondary Outcome Measures
- behavior patterns of the sniff dogs to different diseases [12 months]
The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination.
Other Outcome Measures
- the substances used for identifying tumors by the sniff dogs [12 months]
GCMS etc will be used to compare the volatile compounds between the sera from cancers patients and the from non-cancer subjects, the suspected VOCs will be tested by the dog for conformation.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Healthy volunteers who have been examined by the currently used procedures and find to be without tumors.
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Patients in the breast surgery, thoracic surgery, gynecological and neurosurgery departments with lesions with characteristics of tumors
Exclusion Criteria:
- Patients who have had pathological results
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Center for Scientific Research with Animal Models, CSU | Changsha | Hunan | China | 410008 |
Sponsors and Collaborators
- Chang-Qing Gao
Investigators
- Principal Investigator: Chang-Qing Gao, MD PhD, Central South University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Xiang-Ya 0003
- XY 0003