SCREEN: Electronic Early Notification of Sepsis in Hospitalized Ward Patients
Study Details
Study Description
Brief Summary
Screening for sepsis has been recommended by the Surviving Sepsis Campaign Clinical Practice Guidelines to facilitate early identification and early management of sepsis. However, the optimal tool remains unknown.The objective of this trial is to examine the effect of an electronic sepsis alert tool on reducing hospital mortailty in patients admitted to medical-surgical-oncology wards.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The study aims to examine the effect of screening for sepsis using an electronic sepsis alert versus no alert in hospitalized patients admitted to wards using an active sepsis alert system compared with wards with no active (masked) sepsis alert system on hospital mortality by day 90.
The wards will be randomized in a stepped-wedge cluster fashion.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Experimental wards Active sepsis e-alert |
Other: sepsis e-alert
At 2-each month interval, the e-alert will be activated in five new randomly selected wards, until all wards eventually will have active alert
|
| No Intervention: Contol wards Masked sepsis e-alert. The wards will have masked sepsis e-alert. |
Outcome Measures
Primary Outcome Measures
- All-cause hospital mortality by day 90 [90 Day]
Percentage of all-cause hospital mortality
Secondary Outcome Measures
- Hospital length of stay [90 Day]
Censored at 90 days
- Transfer to ICU [90 Day]
ICU admission within 90 days
- ICU-free days [90 Day]
In the first 90 days
- Critical care response team activation [90 Day]
Critical care response team activation within 90 days
- Cardiac arrest [90 Day]
Cardiac arrest within 90 days
- The need for mechanical ventilation, vasopressor therapy, and incident renal replacement therapy [90 Day]
Within 90 days
- Antibiotic-free days [90 Day]
Antibiotic-free days within 90 days
- The acquisition of MDROs [90 Day]
The percentage of patients with MDROs within 90 days
- Clostridium difficile infection [90 Day]
The percentage of patients with clostridium difficile infection within 90 days
Eligibility Criteria
Criteria
Ward level inclusion and exclusion criteria
Inclusion Criteria:
- Inpatient wards, defined as wards used to manage inpatients, in the five Ministry of National Guard Health Affairs (MNGHA) hospitals, Kingdom of Saudi Arabia
Exclusion Criteria:
-
Cardiology, transplant, pediatric, obstetric wards
-
Intensive Care Units and Emergency Department
-
Operating rooms
-
Outpatients
-
Day care wards, endoscopy, outpatient procedure areas, hemodialysis units.
Patient level inclusion and exclusion criteria
Inclusion Criteria:
-
Aged 14 years or older
-
Checked in as inpatient status to one of the study ward
Exclusion Criteria:
- No commitment for full life support on the time of arrival to the study ward
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Intensive Care Department, King Abdulaziz Medical City, National Guard Health Affairs | Riyadh | Saudi Arabia | 11426 |
Sponsors and Collaborators
- King Abdullah International Medical Research Center
- King Abdulaziz Medical City, Jeddah
- Prince Mohammed Bin Abdul Aziz Hospital - AlMadinah
- King Abdulaziz Hospital, Al Ahsa
- Imam Abdulrahman Al Faisal Hospital - Dammam
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RC18/112